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Oral probiotics can resolve urogenital infections
Open accessAbstract
We report the first clinical evidence that probiotic lactobacilli can be delivered to the vagina following oral intake. In 10 women with a history of recurrent yeast vaginitis, bacterial vaginosis (BV) and urinary tract infections, strains Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14 suspended in skim milk and given twice daily for 14 days, were recovered from the vagina and identified by morphology and molecular typing within 1 week of commencement of therapy. In six cases of asymptomatic BV or intermediate BV (based upon Nugent scoring) was resolved within 1 week of therapy.
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“Evidence supports the translocation of gastrointestinal Lactobacillus strains to the vagina (gut-vagina axis), suggesting that oral probiotic intake may be directly linked with improved vaginal microbiota balance and local immune responses [55].”
From Women's health is a team effort: probiogenomics supports the development of a multi-species vaginal probiotic (2026) · cites this paper as [55]
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Cadieux, P. A., WATTERSON, J. D., Denstedt, J. D., Harbottle, R. R., Puskas, J. E., Howard, J., Gan, B. S., & Reid, G. (2003) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(02)00147-9 · Cited by 31
Self-citationPrevention of Proteus mirabilis Biofilm by Surfactant Solution
Ali, O. A. (2012) · Egyptian Academic Journal of Biological Sciences. G, Microbiology · doi:10.21608/eajbsg.2012.16653 · Cited by 31
Role of probiotics in the treatment of intestinal infections and inflammation
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Metadata
- Authors
- Reid, G., Bruce, A. W., Fraser, N., Heinemann, C., Owen, J., & Henning, B.
- Affiliations
- Western University (CA)
- Lawson Research Institute (CA)
- Corresponding author
- Reid, Gregor
- ORCID
- Reid, Gregor
- Venue
- FEMS Immunology & Medical Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02
- Volume
- 30
- Issue
- 1
- Pages
- 49-52
- ISSN
- 0928-8244 (ISSN-L)
- 1574-695X
- OpenAlex
- W2130187365
- Cited by
- 464
- References
- 20
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 14 · 2023: 32 · 2022: 19 · 2021: 24 · 2020: 15 · 2019: 19 · 2018: 12 · 2017: 22 · 2016: 22 · 2015: 14 · 2014: 27 · 2013: 33 · 2012: 24
- FWCI
- 30.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Immunology & Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Urology › Urinary Tract Infections Management
- Keywords
- oral probiotics, vaginal lactobacilli, Lactobacillus rhamnosus GR-1, bacterial vaginosis, urinary tract infection, urogenital infections, Nugent score
- MeSH terms
- Administration, Oral, Bacterial Infections, Female, Humans, Lactobacillus, Vagina, Probiotics, Female Urogenital Diseases
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