Dependence between dissolution rate and porosity of compressed erythromycin acistrate tablets
Abstract
The correlation between dissolution rate and porosity of compressed erythromycin acistrate tablets was studied. The total porosity of the tablets, the pore size distribution and the specific surface area of the pores were determined using high-pressure mercury porosimetry. The particle size and specific surface area of the raw material and of the dry granulated mass of the tablets were also determined. The results show that the pore size distribution, showing the differences in pore structure, is more informative than total intruded volume of mercury. However, it is very difficult to explain the dissolution behaviour of erythromycin acistrate tablets only by porosity results of the tablets, and more work is still needed in this field.
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Mercury and helium porosimetry, the usual porosity techniques, take considerable time and damage the sample.
“This may be due partly to the relatively time-consuming and destructive nature of existing conventional porosity measurement methods like mercury or helium porosimetry 16,29,30 .”
From A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets (2021) · cites this paper as [29]
In the late 1990s, a promising association was reported between tablet porosity and how quickly erythromycin acistrate dissolved.
“Riippi et al., 29 have initially reported on a promising correlation between porosity and dissolution rate of erythromycin acistrate from tablet samples in the late 1990s.”
From A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets (2021) · cites this paper as [29]
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Characterisation of pore structures of pharmaceutical tablets: A review
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A Fast and Non-destructive Terahertz Dissolution Assay for Immediate Release Tablets
Bawuah, P., Markl, D., Turner, A., Evans, M., Portieri, A., Farrell, D., Lucas, R., Anderson, A., Goodwin, D. J., & Zeitler, J. A. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2020.11.041 · Cited by 45 · see citing works
- Authors
- Riippi, M., Yliruusi, J., Niskanen, T., & Kiesvaara, J.
- Affiliations
- University of Helsinki (FI)
- Orion Corporation (Finland) (FI)
- Corresponding author
- Riippi, Merja
- Venue
- European Journal of Pharmaceutics and Biopharmaceutics
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 46
- Issue
- 2
- Pages
- 169-175
- ISSN
- 0939-6411 (ISSN-L)
- OpenAlex
- W2090177184
- Cited by
- 35
- References
- 10
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 3 · 2018: 4 · 2016: 4 · 2015: 3 · 2014: 1 · 2012: 3
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Engineering › Computational Mechanics › Granular flow and fluidized beds
- Physical Sciences › Materials Science › Materials Chemistry › Crystallization and Solubility Studies
- Keywords
- tablet porosity, dissolution rate, pore size distribution, specific surface area, compressed tablets, dry granulation, particle size
- MeSH terms
- Erythromycin, Kinetics, Microscopy, Electron, Scanning, Molecular Conformation, Particle Size, Prodrugs, Solubility, Tablets, Molecular Structure
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