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Determinants of SR protein specificity
Open accessAbstract
The SR (Ser-Arg) proteins are a family of nuclear factors that play multiple important roles in splicing of mRNA precursors in metazoan organisms, functioning in both constitutive and regulated splicing. Certain of these functions are redundant, such that any single SR proteins will suffice, but other functions are unique and are specific to a given family member. A number of studies during the past year have investigated the basis for SR protein specificity.
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Citations
Cited by
Mechanisms of Alternative Pre-Messenger RNA Splicing
Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284
Self-citationComprehensive proteomic analysis of the human spliceosome
Zhou, Z., Licklider, L. J., Gygi, S. P., & Reed, R. (2002) · Nature · doi:10.1038/nature01031 · Cited by 893
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
Guo, W., Schafer, S., Greaser, M. L., Radke, M. H., Liss, M., Govindarajan, T., Maatz, H., Schulz, H., Li, S., Parrish, A. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2693 · Cited by 589
Dowhan, D. H., Hong, E. P., Auboeuf, D., Dennis, A. P., Wilson, M. M., Berget, S. M., & O'Malley, B. W. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.025 · Cited by 193
Metadata
- Authors
- Tacke, R., & Manley, J. L.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 11
- Issue
- 3
- Pages
- 358-362
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2025607175
- Cited by
- 225
- References
- 0
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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