Cited by 127Fatty Acid Research and HealthEdible Oils Quality and AnalysisAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 52 of the 54 references it cites were found in a registry or an index.

Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT

Ciubotaru, Irina, Lee, Ye-Sun, Wander, Rosemary C.·2003·The Journal of Nutritional Biochemistry

Open this paper in CoChat — free account

Abstract

Background Atherogenesis is a complex process involving both a low-grade inflammation and a disturbed lipid profile. Although dietary fish and fish oil improve the latter of these two risk factors, their impact on the former is less clear.Objective This study addressed the effect of supplementation with fish oil in doses achievable with diet on serum C-reactive protein (CRP), interleukin-6 (IL-6), and the lipid profile.Methods and results Thirty healthy subjects taking HRT were randomly divided into three groups and supplemented for five weeks with 14 g/day safflower oil (SO), 7 g/day of both safflower oil and fish oil (LFO), or 14 g/day fish oil (HFO). Measurements included serum high-sensitivity CRP, IL-6 in plasma and in cell culture supernatant collected from 24-hr lipopolysaccharide (LPS)-stimulated whole blood, and lipid profile markers. CRP and IL-6 were adjusted for body mass index (BMI). Fish oil supplementation significantly decreased CRP and IL-6 compared to SO, with a greater effect in the LFO than HFO groups. Plasma triacylglycerol (TG) and the TG/HDL-C ratio were significantly lower in the HFO compared to the SO group.Conclusions These results suggest that dietary fish oil may decrease the risk for cardiovascular disease through the modulation of both plasma lipids and inflammatory markers in healthy postmenopausal women.

Integrity signals

Registry

Crossref · 10.1016/s0955-2863(03)00101-3

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Statistical Power Analysis for the Behavioral Sciences (2nd ed.).
Lachenbruch, P. A., & Cohen, J. (1989) · Journal of the American Statistical Association · doi:10.2307/2290095 · Cited by 37,421
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
Enzymatic determination of total serum cholesterol.
Allain, C. C., Poon, L. S., Chan, C. S. G., Richmond, W., & Fu, P. C. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.4.470 · Cited by 9,845
C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
(1999) · The Lancet · doi:10.1016/s0140-6736(99)07072-5 · Cited by 3,812
Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Among Apparently Healthy Women
Ridker, P. M., Buring, J. E., Shih, J., Matias, M., & Hennekens, C. H. (1998) · Circulation · doi:10.1161/01.cir.98.8.731 · Cited by 1,642
AHA Dietary Guidelines: Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association
Krauss, R. M., Eckel, R. H., Howard, B., Appel, L. J., Daniels, S. R., Deckelbaum, R. J., Erdman, J. W., Kris-Etherton, P., Goldberg, I. J., Kotchen, T. A., et al. (2000) · Circulation · doi:10.1161/01.cir.102.18.2284 · Cited by 1,458
A peroxidase-coupled method for the colorimetric determination of serum triglycerides.
McGowan, M. W., Artiss, J. D., Strandbergh, D. R., & Zak, B. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.3.538 · Cited by 1,298
n-3 fatty acids and serum lipoproteins: human studies
Harris, W. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1645s · Cited by 1,243
Menopause and the Risk of Coronary Heart Disease in Women
Colditz, G. A., Willett, W. C., Stampfer, M. J., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1987) · New England Journal of Medicine · doi:10.1056/nejm198704303161801 · Cited by 1,153
Hypertriglyceridemia as a cardiovascular risk factor
Austin, M. A., Hokanson, J. E., & Edwards, K. L. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00031-9 · Cited by 1,066
Relationship of C-Reactive Protein to Risk of Cardiovascular Disease in the Elderly: Results From the Cardiovascular Health Study and the Rural Health Promotion Project
Tracy, R. P., Lemaitre, R. N., Psaty, B. M., Ives, D. G., Evans, R. W., Cushman, M., Meilahn, E. N., & Kuller, L. H. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.6.1121 · Cited by 836
Effect of alcohol consumption on systemic markers of inflammation
Imhof, A., Froehlich, M., Brenner, H., Boeing, H., Pepys, M. B., & Koenig, W. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04170-2 · Cited by 559
Interrelationships Among Circulating Interleukin-6, C-Reactive Protein, and Traditional Cardiovascular Risk Factors in Women
Bermudez, E. A., Rifai, N., Buring, J. E., Manson, J. E., & Ridker, P. M. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000029781.31325.66 · Cited by 470
Hormone Replacement Therapy and Increased Plasma Concentration of C-Reactive Protein
Ridker, P. M., Hennekens, C. H., Rifai, N., Buring, J. E., & Manson, J. E. (1999) · Circulation · doi:10.1161/01.cir.100.7.713 · Cited by 442
Cross-sectional and Prospective Relationships of Interleukin-6 and C-Reactive Protein With Physical Performance in Elderly Persons: MacArthur Studies of Successful Aging
Taaffe, D. R., Harris, T. B., Ferrucci, L., Rowe, J., & Seeman, T. E. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.12.m709 · Cited by 438
‘Statistical’, ‘practical’, and ‘clinical’: How many kinds of significance do counselors need to consider
Thompson, B. (2002) · Journal of Counseling & Development · doi:10.1002/j.1556-6678.2002.tb00167.x · Cited by 398
Biological Data Analysis: A Practical Approach.
Fry, J. C. (1994) · Biometrics · doi:10.2307/2533236 · Cited by 283
Immunoradiometric Assay of Circulating C-Reactive Protein: Age-related Values in the Adult General Population
Hutchinson, W. L., Köenig, W., Fröhlich, M., Sund, M., Lowe, G. D. O., & Pepys, M. B. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.7.934 · Cited by 250
Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein
Vickers, M. A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00534-x · Cited by 249
Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis
Zee, R. Y. L., & Ridker, P. M. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00703-1 · Cited by 206
High Performance reversed phase chromatography of Natural triglyceride mixtures: Critical pair separation
Hamdy, A. H. E., & Perkins, E. G. (1981) · Journal of the American Oil Chemists Society · doi:10.1007/bf02672960 · Cited by 154
Effect of Atorvastatin and Fish Oil on Plasma High-Sensitivity C-Reactive Protein Concentrations in Individuals with Visceral Obesity
Chan, D. C., Watts, G. F., Barrett, P. H. R., Beilin, L. J., & Mori, T. A. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.6.877 · Cited by 151
Raised C-reactive protein levels in serum from smokers
Das, I. (1985) · Clinica Chimica Acta · doi:10.1016/0009-8981(85)90133-0 · Cited by 149
Biological Data Analysis
(1993) · doi:10.1093/oso/9780199633401.001.0001 · Cited by 145
C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease
Madsen, T., Skou, H. A., Hansen, V. E., Fog, L., Christensen, J. H., Toft, E. S., & Schmidt, E. B. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02049-5 · Cited by 137
Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F2-isoprostanes
Higdon, J. V., Liu, J., Du, S.-H., Morrow, J. D., Ames, B. N., & Wander, R. C. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.714 · Cited by 124
C-REACTIVE PROTEIN LEVELS ARE INFLUENCED BY COMMON IL-1 GENE VARIATIONS
Berger, P. B., McConnell, J. P., Nunn, M. E., Kornman, K. S., Sorrell, J., Stephenson, K. E., & Duff, G. W. (2002) · Cytokine · doi:10.1006/cyto.2001.0974 · Cited by 117
Dose-Response Studies on the Effect of n-3 Polyunsaturated Fatty Acids on Lipids and Haemostasis
Schmidt, E. B., Varming, K., Ernst, E., Madsen, P., & Dyerberg, J. (1990) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1645675 · Cited by 115
Relative Importance of Various Risk Factors for Asymptomatic Carotid Atherosclerosis versus Coronary Heart Disease Incidence: The Atherosclerosis Risk In Communities Study
Sharrett, A. R., Sorlie, P. D., Chambless, L. E., Folsom, A. R., Hutchinson, R. G., HEISS, G. M., & Szklo, M. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009900 · Cited by 103
High performance reversed‐phase chromatography of natural triglyceride mixtures
El‐Hamdy, A. H., & Perkins, E. G. (1981) · Journal of the American Oil Chemists Society · doi:10.1007/bf02666054 · Cited by 96
Risk factors for coronary artery disease in women
Knopp, R. H. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02409-8 · Cited by 94
Oxidation of plasma proteins is not increased after supplementation with eicosapentaenoic and docosahexaenoic acids
Wander, R. C., & Du, S.-H. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.731 · Cited by 85
C-reactive Protein and Coronary Artery Disease
Auer, J., Berent, R., Laßnig, E., & Eber, B. (2002) · Japanese Heart Journal · doi:10.1536/jhj.43.607 · Cited by 81
Differential Effects of E and Droloxifene on C-Reactive Protein and Other Markers of Inflammation in Healthy Postmenopausal Women
Herrington, D. M., Brosnihan, K. B., Pusser, B. E., Seely, E. W., Ridker, P. M., Rifai, N., & MacLean, D. B. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7799 · Cited by 80
C-reactive protein and coronary artery disease: influence of obesity, caloric restriction and weight loss
Heilbronn, L. K., & Clifton, P. M. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00187-0 · Cited by 80
Effect of a fish-oil concentrate on serum lipids in postmenopausal women receiving and not receiving hormone replacement therapy in a placebo-controlled, double-blind trial
Stark, K. D., Park, E. J., Maines, V. A., & Holub, B. J. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.389 · Cited by 71
Cancer cachexia and its treatment with fish-oil-enriched nutritional supplementation
Barber, M. D. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00631-1 · Cited by 59
Dealing with baseline differences: two principles and two dilemmas
Jamieson, J. (1999) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(98)00048-8 · Cited by 49
Comparison of three species of fish consumed as part of a Western diet: effects on platelet fatty acids and function, hemostasis, and production of thromboxane
Wander, R. C., & Patton, B. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.2.326 · Cited by 46
Analysis of plasma lipoproteins by ultracentrifugation in a new fixed angle rotor: Evaluation of a phosphotungstic acid/MgCl2 precipitation and a quantitative lipoprotein electrophoresis assay
März, W., & Groß, W. (1986) · Clinica Chimica Acta · doi:10.1016/0009-8981(86)90330-x · Cited by 40
Modulation of Human Hepatocyte Acute Phase Protein Production In Vitro by n-3 and n-6 Polyunsaturated Fatty Acids
Wigmore, S. J., Fearon, K. C. H., & Ross, J. A. (1997) · Annals of Surgery · doi:10.1097/00000658-199701000-00012 · Cited by 35
n‐3 fatty acids and acute‐phase proteins
ERNST, E., Saradeth, T., & Achhammer, G. (1991) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1991.tb01362.x · Cited by 33
Effects of Dietary Selenium and Fish Oil (MaxEPA) on Arachidonic Acid Metabolism and Hemostatic Function in Rats
Song, J., & Wander, R. C. (1991) · Journal of Nutrition · doi:10.1093/jn/121.3.284 · Cited by 30
Effects of low dose hormone replacement therapy on markers of inflammation in postmenopausal women
Goudev, A., Georgiev, D. B., Koycheva, N., Manassiev, N., & Kyurkchiev, S. (2002) · Maturitas · doi:10.1016/s0378-5122(02)00182-2 · Cited by 27
National differences in lipid response to postmenopausal hormone replacement therapy
Ranta, V., Oksanen, H. M., Arrenbrecht, S., & Ylikorkala, O. (2002) · Maturitas · doi:10.1016/s0378-5122(02)00139-1 · Cited by 10

Research works printed but not linked: 1

Ridker, 1999, Hormone replacement therapy and increased plasma concentration of C-reactive protein, Circulation, 10, 713, 10.1161/01.CIR.100.7.713 · DOI

Sorted by citations

Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction
Fung, T. T., McCullough, M. L., Newby, P., Manson, J. E., Meigs, J. B., Rifai, N., Willett, W. C., & Hu, F. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.163 · Cited by 1,001
IL-10, IL-6, and TNF-α: Central factors in the altered cytokine network of uremia—The good, the bad, and the ugly
Stenvinkel, P., Ketteler, M., Johnson, R. J., Lindholm, B., Pecoits‐Filho, R., RIELLA, M. C., Heimbürger, O., Cederholm, T., & Girndt, M. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00200.x · Cited by 952
The Effects of Diet on Inflammation
Giugliano, D., Ceriello, A., & Esposito, K. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.03.052 · Cited by 842
Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
Adkins, Y. C., & Kelley, D. S. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.12.004 · Cited by 577

See all 127

Authors: Ciubotaru, I., Lee, Y.-S., & Wander, R. C.
Affiliations: University of North Carolina at Greensboro (US)
Corresponding author: Wander, Rosemary C.
Venue: The Journal of Nutritional Biochemistry
Publisher: Elsevier BV
Published: 2003-09
Volume: 14
Issue: 9
Pages: 513-521
ISSN: 0955-2863 (ISSN-L)
DOI: 10.1016/s0955-2863(03)00101-3
OpenAlex: W2073016573
Cited by: 127
References: 54
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 10 · 2014: 7 · 2013: 8 · 2012: 6
FWCI: 6.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Nutritional Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: fish oil supplementation, dietary fish oil, C-reactive protein, interleukin-6, safflower oil, postmenopausal women, hormone replacement therapy, triglycerides, HDL cholesterol, triglyceride to HDL cholesterol ratio, low-grade inflammation, lipid profile, cardiovascular risk
MeSH terms: Adult, C-Reactive Protein, Cardiovascular Diseases, Dietary Fats, Unsaturated, Double-Blind Method, Female, Fish Oils, Humans, Cholesterol, HDL, Middle Aged, Placebos, Safflower Oil, Triglycerides, Interleukin-6, Estrogen Replacement Therapy, Postmenopause

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks