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Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT

Ciubotaru, Irina, Lee, Ye-Sun, Wander, Rosemary C.·2003·The Journal of Nutritional Biochemistry

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Abstract

Background Atherogenesis is a complex process involving both a low-grade inflammation and a disturbed lipid profile. Although dietary fish and fish oil improve the latter of these two risk factors, their impact on the former is less clear.Objective This study addressed the effect of supplementation with fish oil in doses achievable with diet on serum C-reactive protein (CRP), interleukin-6 (IL-6), and the lipid profile.Methods and results Thirty healthy subjects taking HRT were randomly divided into three groups and supplemented for five weeks with 14 g/day safflower oil (SO), 7 g/day of both safflower oil and fish oil (LFO), or 14 g/day fish oil (HFO). Measurements included serum high-sensitivity CRP, IL-6 in plasma and in cell culture supernatant collected from 24-hr lipopolysaccharide (LPS)-stimulated whole blood, and lipid profile markers. CRP and IL-6 were adjusted for body mass index (BMI). Fish oil supplementation significantly decreased CRP and IL-6 compared to SO, with a greater effect in the LFO than HFO groups. Plasma triacylglycerol (TG) and the TG/HDL-C ratio were significantly lower in the HFO compared to the SO group.Conclusions These results suggest that dietary fish oil may decrease the risk for cardiovascular disease through the modulation of both plasma lipids and inflammatory markers in healthy postmenopausal women.

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Authors: Ciubotaru, I., Lee, Y.-S., & Wander, R. C.
Affiliations: University of North Carolina at Greensboro (US)
Corresponding author: Wander, Rosemary C.
Venue: The Journal of Nutritional Biochemistry
Publisher: Elsevier BV
Published: 2003-09
Volume: 14
Issue: 9
Pages: 513-521
ISSN: 0955-2863 (ISSN-L)
DOI: 10.1016/s0955-2863(03)00101-3
OpenAlex: W2073016573
Cited by: 127
References: 54
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 10 · 2014: 7 · 2013: 8 · 2012: 6
FWCI: 6.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Nutritional Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: fish oil supplementation, dietary fish oil, C-reactive protein, interleukin-6, safflower oil, postmenopausal women, hormone replacement therapy, triglycerides, HDL cholesterol, triglyceride to HDL cholesterol ratio, low-grade inflammation, lipid profile, cardiovascular risk
MeSH terms: Adult, C-Reactive Protein, Cardiovascular Diseases, Dietary Fats, Unsaturated, Double-Blind Method, Female, Fish Oils, Humans, Cholesterol, HDL, Middle Aged, Placebos, Safflower Oil, Triglycerides, Interleukin-6, Estrogen Replacement Therapy, Postmenopause

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Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT

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