Cytotoxic Impacts of Linear and Branched Polyethylenimine Nanostructures in A431 Cells
Open accessAbstract
Introduction: Polyethylenimine (PEI), as a nonviral cationic polymer, has been widely used as gene delivery nanosystem. Although a number of investigations have highlighted its toxic impacts on target cells through induction of apoptosis/necrosis, still it is essential to look at its structural impacts on target cells. Methods: In this current study, cytogenomic impacts of 25 kD linear and branched PEI (LPEI and BPEI, respectively) in A431 cells are reported to address possible mechanism for induction of apoptosis. At 40-50% confluency, A431 cells were exposed to PEI at a recommended concentration for 4 hr. After 24 hr, to detect apoptosis and DNA damage, the treated cells were subjected to MTT assay, FITC-labeled annexin V flow cytometry and comet assay. Results: Flow cytometry assessments revealed that the BPEI can result in greater internalization than the linear PEI, which also induced greater cytotoxicity. Annexin V assay confirmed early and late apoptosis by BPEI, imposing somewhat DNA damage detected by comet assay. Western blot analysis resulted in induction of Akt-kinase which is possibly one of biomolecules affected by PEI. Conclusion: These results highlight that, despite induction of Akt-kinase, the BPEI can elicit apoptosis in target cells.
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Cites
Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256 · see citing works
Polyethylenimine-based non-viral gene delivery systems
Lungwitz, U., Breunig, M., Blunk, T., & Göpferich, A. M. (2005) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.11.011 · Cited by 985 · see citing works
Non-viral gene delivery systems
Davis, M. E. (2002) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(02)00294-x · Cited by 419 · see citing works
A Degradable Polyethylenimine Derivative with Low Toxicity for Highly Efficient Gene Delivery
Forrest, M. L., Koerber, J. T., & Pack, D. W. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034014g · Cited by 387 · see citing works
Florea, B. I., Meaney, C., Junginger, H. E., & Borchard, G. (2002) · AAPS PharmSci · doi:10.1208/ps040312 · Cited by 243 · see citing works
Stability of PEI–DNA and DOTAP–DNA complexes: effect of alkaline pH, heparin and serum
Moret, I., Peris, J., Guillem, V. M., Benet, M., Revert, F., Dası́, F., Crespo, A., & Aliño, S. F. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00415-1 · Cited by 236 · see citing works
Wen, Y., Pan, S., Luo, X., Zhang, X., Zhang, W., & Feng, M. (2009) · Bioconjugate Chemistry · doi:10.1021/bc800428y · Cited by 169 · see citing works
Omidi, Y., Hollins, A. J., Drayton, R. M., & Akhtar, S. (2005) · Journal of drug targeting · doi:10.1080/10611860500418881 · Cited by 143 · see citing works
Self-citationPolyethylenimine-grafted copolymer of poly(l-lysine) and poly(ethylene glycol) for gene delivery
Dai, J., Zou, S., Pei, Y., Cheng, D., Ai, H., & Shuai, X. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.10.044 · Cited by 122 · see citing works
Hollins, A. J., Omidi, Y., Benter, I. F., & Akhtar, S. (2007) · Journal of drug targeting · doi:10.1080/10611860601151860 · Cited by 116 · see citing works
Self-citationXiong, M. P., Forrest, M. L., Ton, G. N., Zhao, A., Davies, N. M., & Kwon, G. S. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.043 · Cited by 114 · see citing works
The Potential Role of Proteoglycans in Cationic Lipid-mediated Gene Delivery
Wiethoff, C. M., Smith, J. G., Koe, G. S., & Middaugh, C. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007940200 · Cited by 105 · see citing works
Nucleocytoplasmic transport of plasmid DNA: a perilous journey from the cytoplasm to the nucleus
Lechardeur, D., & Lukacs, G. L. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.882 · Cited by 99 · see citing works
Oskuee, R. K., Dehshahri, A., Shier, W. T., & Ramezani, M. (2009) · The Journal of Gene Medicine · doi:10.1002/jgm.1374 · Cited by 92 · see citing works
Toxicogenomics of Cationic Lipid-based Vectors for Gene Therapy: Impact of Microarray Technology
Omidi, Y., Barar, J., & Akhtar, S. (2005) · Current Drug Delivery · doi:10.2174/156720105774370249 · Cited by 89 · see citing works
Self-citationEffect of acyl chain length on transfection efficiency and toxicity of polyethylenimine
Aravindan, L., Bicknell, K. A., Brooks, G., Khutoryanskiy, V. V., & Williams, A. C. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.05.052 · Cited by 88 · see citing works
Recent Advances in Non‐viral Gene Delivery
Conwell, C. C., & Huang, L. (2005) · Advances in genetics · doi:10.1016/s0065-2660(05)53001-3 · Cited by 82 · see citing works
Omidi, Y., Barar, J., Heidari, H. R., Ahmadian, S., Yazdi, H. A., & Akhtar, S. (2008) · Toxicology Mechanisms and Methods · doi:10.1080/15376510801891286 · Cited by 68 · see citing works
Self-citationInduction of Human Alveolar Epithelial Cell Growth Factor Receptors by Dendrimeric Nanostructures
Omidi, Y., & Barar, J. (2009) · International Journal of Toxicology · doi:10.1177/1091581809335177 · Cited by 45 · see citing works
Self-citationSynthesis of glycosylated polyethylenimine with reduced toxicity and high transfecting efficiency
Leclercq, F., Dubertret, C., Pitard, B., Scherman, D., & Herscovici, J. (2000) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(00)00195-5 · Cited by 26 · see citing works
Steele, T. W. J., & Shier, W. T. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0058-1 · Cited by 24 · see citing works
Yoon, C. S., Jung, H. S., Kim, T. K., Kwon, M. J., Kim, M.-K., Lee, M., Koh, K. S., Rhee, B. D., & Park, J. H. (2008) · Journal of drug targeting · doi:10.1080/10611860802470549 · Cited by 16 · see citing works
Detection of B lymphoma cells undergoing apoptosis by Annexin-V assay.
Peng, L., Jiang, H., & Bradely, C. (2002) · PubMed · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Exploring treatment options in cancer: tumor treatment strategies
Liu, B., Zhou, H., Tan, L., Siu, K. T. H., & Guan, X.-Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01856-7 · Cited by 1,201 · see citing works
Self‐Healing Hydrogels: The Next Paradigm Shift in Tissue Engineering?
Talebian, S., Mehrali, M., Taebnia, N., Pennisi, C. P., Kadumudi, F. B., Foroughi, J., Hasany, M., Nikkhah, M., Akbari, M., Orive, G., et al. (2019) · Advanced Science · doi:10.1002/advs.201801664 · Cited by 603 · see citing works
Abdelaziz, H. M., Gaber, M. K., Elwakil, M. M. A., Mabrouk, M. T., Elgohary, M. M., Kamel, N. M., Kabary, D. M., Freag, M. S., Samaha, M. W., Mortada, S. M., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.11.036 · Cited by 409 · see citing works
Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery
Zhou, J., Liu, J., Cheng, C. J., Patel, T., Weller, C. E., Piepmeier, J. M., Jiang, Z., & Saltzman, W. M. (2011) · Nature Materials · doi:10.1038/nmat3187 · Cited by 388 · see citing works
Rai, R., Alwani, S., & Badea, I. (2019) · Polymers · doi:10.3390/polym11040745 · Cited by 350 · see citing works
Blood-brain barrier transport machineries and targeted therapy of brain diseases
Barar, J., Rafi, M. A., Pourseif, M. M., & Omidi, Y. (2016) · Bioimpacts · doi:10.15171/bi.2016.30 · Cited by 259 · see citing works
Self-citationNanotoxicity: A Key Obstacle to Clinical Translation of siRNA-Based Nanomedicine
Xue, H. Y., Liu, S., & Wong, H. L. (2014) · Nanomedicine · doi:10.2217/nnm.13.204 · Cited by 251 · see citing works
Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic
van den Berg, A. I. S., Yun, C., Schiffelers, R. M., & Hennink, W. E. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.01.014 · Cited by 209 · see citing works
Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy
Barar, J., & Omidi, Y. (2013) · Europe PMC (PubMed Central) · doi:10.5681/bi.2013.036 · Cited by 177 · see citing works
Self-citationFunctionalized carbon nanotubes as emerging delivery system for the treatment of cancer
Mahajan, S., Patharkar, A., Kuche, K., Maheshwari, R., Deb, P. K., Kalia, K., & Tekade, R. K. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.07.027 · Cited by 157 · see citing works
Polymeric Engineering of Nanoparticles for Highly Efficient Multifunctional Drug Delivery Systems
Fortuni, B., Inose, T., Ricci, M., Fujita, Y., Zundert, I. V., Masuhara, A., Fron, E., Mizuno, H., Latterini, L., Rocha, S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39107-3 · Cited by 155 · see citing works
Impacts of quantum dots in molecular detection and bioimaging of cancer
Mashinchian, O., Ahar, M. J., Ghaemi, B., Rashidi, M., Barar, J., & Omidi, Y. (2014) · Bioimpacts · doi:10.15171/bi.2014.008 · Cited by 128 · see citing works
Self-citationNovel Delivery Strategies for Glioblastoma
Zhou, J., Atsina, K., Himes, B. T., Strohbehn, G. W., & Saltzman, W. M. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e318244d8ae · Cited by 124 · see citing works
Majd, M. H., Asgari, D., Barar, J., Valizadeh, H., Kafil, V., Abadpour, A., Moumivand, E., Mojarrad, J. S., Rashidi, M., Coukos, G., et al. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.01.051 · Cited by 110 · see citing works
Self-citationSolid lipid-based nanocarriers as efficient targeted drug and gene delivery systems
Dolatabadi, J. E. N., & Omidi, Y. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.12.016 · Cited by 104 · see citing works
Self-citationChang, J.-H., Tsai, P., Wang, K., Wei, Y.-T., Chiou, S., & Mou, C. (2018) · Scientific Reports · doi:10.1038/s41598-017-18324-8 · Cited by 104 · see citing works
Cui, J., Qin, L., Zhang, J., Abrahimi, P., Li, H., Li, G., Tietjen, G. T., Tellides, G., Pober, J. S., & Saltzman, W. M. (2017) · Nature Communications · doi:10.1038/s41467-017-00297-x · Cited by 102 · see citing works
Polymeric siRNA gene delivery – transfection efficiency versus cytotoxicity
Kargaard, A., Sluijter, J. P. G., & Klumperman, B. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.046 · Cited by 97 · see citing works
The role of polymers in enabling RNAi-based technology for sustainable pest management
Quilez‐Molina, A. I., Sánchez, J. N., & Merino, D. (2024) · Nature Communications · doi:10.1038/s41467-024-53468-y · Cited by 96 · see citing works
Gutiérrez-Granados, S., Cervera, L., Kamen, A., & Gòdia, F. (2018) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2017.1419459 · Cited by 92 · see citing works
Non-viral based miR delivery and recent developments
Labatut, A. E., & Mattheolabakis, G. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.04.018 · Cited by 91 · see citing works
Viegas, J. S. R., Praça, F. S. G., Caron, A. L., Suzuki, I., Silvestrini, A. V. P., Medina, W. S. G., Ciampo, J. O. D., Kravicz, M., & Bentley, M. V. L. B. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00723-6 · Cited by 90 · see citing works
Stimuli-responsive chitosan-based nanocarriers for cancer therapy
Fathi, M., Sahandi Zangabad, P., Majidi, S., Barar, J., Erfan-Niya, H., & Omidi, Y. (2017) · BioImpacts · doi:10.15171/bi.2017.32 · Cited by 87 · see citing works
Self-citationRiva, L., Fiorati, A., & Punta, C. (2021) · Materials · doi:10.3390/ma14030473 · Cited by 86 · see citing works
Poly(ethyleneimines) in dermal applications: Biocompatibility and antimicrobial effects
Wiegand, C., Bauer, M., Hipler, U., & Fischer, D. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.08.001 · Cited by 85 · see citing works
Barar, J., Kafil, V., Majd, M. H., Barzegari, A., Khani, S., Ahar, M. J., Asgari, D., Coukos, G., & Omidi, Y. (2015) · Journal of Nanobiotechnology · doi:10.1186/s12951-015-0083-7 · Cited by 85 · see citing works
Self-citationPluronic-based nanovehicles: Recent advances in anticancer therapeutic applications
Jarak, I., Varela, C. L., da Silva, E. J. T., Roleira, F. M. F., Veiga, F., & Figueiras, A. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112526 · Cited by 84 · see citing works
Winkeljann, B., Keul, D. C., & Merkel, O. M. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.008 · Cited by 85 · see citing works
Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovarian cancer
Omidi, Y., Matthaiou, E. I., Barar, J., Coukos, G., Sandaltzopoulos, R., & Li, C. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s51880 · Cited by 83 · see citing works
Self-citationErnst, L. M., Casals, E., Italiani, P., Boraschi, D., & Puntes, V. (2021) · Nanomaterials · doi:10.3390/nano11112991 · Cited by 82 · see citing works
Eco-design of nanostructured cellulose sponges for sea-water decontamination from heavy metal ions
Fiorati, A., Grassi, G., Graziano, A., Liberatori, G., Pastori, N., Melone, L., Bonciani, L., Pontorno, L., Punta, C., & Corsi, I. (2019) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2019.119009 · Cited by 77 · see citing works
Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine
Azeez, S. S., Hamad, R. S., Hamad, B., Shekha, M. S., & Bergsten, P. (2024) · Frontiers in Genome Editing · doi:10.3389/fgeed.2024.1509924 · Cited by 84 · see citing works
Fitzsimmons, R., & Uludağ, H. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.07.015 · Cited by 75 · see citing works
Corsi, I., Bellingeri, A., Eliso, M. C., Grassi, G., Liberatori, G., Murano, C., Sturba, L., Vannuccini, M. L., & Bergami, E. (2021) · Nanomaterials · doi:10.3390/nano11081903 · Cited by 71 · see citing works
He, T., Wen, J., Wang, W., Hu, Z., Ling, C., Zhao, Z., Cheng, Y., Chang, Y., Xu, M., Jin, Z., et al. (2024) · Advanced Materials · doi:10.1002/adma.202307679 · Cited by 69 · see citing works
Kauffman, A. C., Piotrowski-Daspit, A. S., Nakazawa, K. H., Jiang, Y., Datye, A., & Saltzman, W. M. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00997 · Cited by 66 · see citing works
Surface modified multifunctional nanomedicines for simultaneous imaging and therapy of cancer
Barar, J., & Omidi, Y. (2014) · Europe PMC (PubMed Central) · doi:10.5681/bi.2014.011 · Cited by 68 · see citing works
Self-citationRahmanian, N., Eskandani, M., Barar, J., & Omidi, Y. (2016) · Journal of drug targeting · doi:10.1080/1061186x.2016.1238475 · Cited by 67 · see citing works
Self-citationNanoparticle-based targeted gene therapy for lung cancer.
Lee, H.-Y., Mohammed, K. A., & Nasreen, N. (2016) · PubMed Central · Cited by 65 · see citing works
Mulholland, E. J., Ali, A., Robson, T., Dunne, N., & McCarthy, H. O. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.050 · Cited by 64 · see citing works
TNFα siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy
Suzuki, I., de Araújo, M. M., Bagnato, V. S., & Bentley, M. V. L. B. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.039 · Cited by 65 · see citing works
Impacts of Blood-Brain Barrier in Drug Delivery and Targeting of Brain Tumors
Omidi, Y., & Barar, J. (2012) · Europe PMC (PubMed Central) · doi:10.5681/bi.2012.002 · Cited by 64 · see citing works
Self-citationNafee, N. A., Makled, S., & Boraie, N. A. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.10.003 · Cited by 62 · see citing works
Graphene-based multifunctional nanosystems for simultaneous detection and treatment of breast cancer
Dolatkhah, M., Hashemzadeh, N., Barar, J., Adibkia, K., Aghanejad, A., Barzegar-Jalali, M., & Omidi, Y. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111104 · Cited by 62 · see citing works
Self-citationSpecific targeting of cancer cells by multifunctional mitoxantrone-conjugated magnetic nanoparticles
Majd, M. H., Asgari, D., Barar, J., Valizadeh, H., Kafil, V., Coukos, G., & Omidi, Y. (2013) · Journal of drug targeting · doi:10.3109/1061186x.2012.750325 · Cited by 59 · see citing works
Self-citationGeno- and cytotoxicity of propyl gallate food additive
Hamishehkar, H., Khani, S., Kashanian, S., Ezzati, A., & Eskandani, M. (2013) · Drug and Chemical Toxicology · doi:10.3109/01480545.2013.838776 · Cited by 59 · see citing works
Naeem, F., Khan, S., Jalil, A., Ranjha, N. M., Riaz, A., Haider, M. S., Sarwar, S., Saher, F., & Afzal, S. (2017) · BioImpacts · doi:10.15171/bi.2017.21 · Cited by 58 · see citing works
Eskandani, M., Barar, J., Ezzati, A., Hamishehkar, H., & Nazemiyeh, H. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2014.991836 · Cited by 58 · see citing works
Khosroushahi, A. Y., Naderi‐Manesh, H., Yeganeh, H., Barar, J., & Omidi, Y. (2012) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-10-2 · Cited by 58 · see citing works
Self-citationSchlenk, F., Werner, S., Rabel, M., Jacobs, F., Bergemann, C., Clement, J. H., & Fischer, D. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-1968-z · Cited by 57 · see citing works
Líbalová, H., Costa, P. M., Olsson, M., Farcal, L. R., Ortelli, S., Blosi, M., Topinka, J., Costa, A. L., & Fadeel, B. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.12.182 · Cited by 54 · see citing works
Kim, Y., Park, S., & Jang, M.-K. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.07.035 · Cited by 53 · see citing works
Lackington, W. A., Raftery, R. M., & O’Brien, F. J. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.06.014 · Cited by 53 · see citing works
Wang, W., Balk, M., Deng, Z., Wischke, C., Gossen, M., Behl, M., Ma, N., & Lendlein, A. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.08.004 · Cited by 51 · see citing works
Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery
Dutta, K., Das, R., Medeiros, J., & Thayumanavan, S. (2021) · Biochemistry · doi:10.1021/acs.biochem.0c00860 · Cited by 48 · see citing works
Zhao, Z., Muylaert, K., Szymczyk, A., & Vankelecom, I. F. J. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.127390 · Cited by 48 · see citing works
Polyethyleneimine (PEI) as a Polymer-Based Co-Delivery System for Breast Cancer Therapy
Fahira, A. I., Amalia, R., Barliana, M. I., Gatera, V. A., & Abdulah, R. (2022) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s350403 · Cited by 46 · see citing works
Pollutant decontamination by polyethyleneimine-engineered agricultural waste materials: a review
Kani, A. N., Dovi, E., Mpatani, F. M., Aryee, A. A., Han, R., Li, Z., & Qu, L. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01328-2 · Cited by 46 · see citing works
Bioreducible, hydrolytically degradable and targeting polymers for gene delivery
Ullah, I., Muhammad, K., Akpanyung, M., Nejjari, A., Neve, A. L., Guo, J., Feng, Y., & Shi, C. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00275k · Cited by 45 · see citing works
Perspective highlights on biodegradable polymeric nanosystems for targeted therapy of solid tumors
Fathi, M., & Barar, J. (2017) · Bioimpacts · doi:10.15171/bi.2017.07 · Cited by 45 · see citing works
Iqbal, S., Qu, Y., Dong, Z., Zhao, J., Khan, A. R., Rehman, S., & Zhao, Z. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.110097 · Cited by 45 · see citing works
Gao, J., Liu, J., Meng, Z., Li, Y., Hong, Y., Wang, L., He, L., Hu, B. Q., Zheng, Y., Li, T., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.015 · Cited by 44 · see citing works
Comet Assay: A Method to Evaluate Genotoxicity of Nano-Drug Delivery System
Vandghanooni, S., & Eskandani, M. (2011) · Europe PMC (PubMed Central) · doi:10.5681/bi.2011.012 · Cited by 44 · see citing works
Khabibullin, V. R., Chetyrkina, M. R., Obydennyi, S. I., Maksimov, S. V., Stepanov, G. V., & Штыков, С. Н. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054480 · Cited by 43 · see citing works
Beha, M. J., Ryu, J. S., Kim, Y. S., & Chung, H. J. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112167 · Cited by 42 · see citing works
Zhang, C., Wu, F., Hu, P., & Chen, Z. (2014) · The Journal of Physical Chemistry C · doi:10.1021/jp502383u · Cited by 41 · see citing works
Kasai, H., Inoue, K., Imamura, K., Yuvienco, C., Montclare, J. K., & Yamano, S. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0444-8 · Cited by 41 · see citing works
Oskuee, R. K., Dabbaghi, M., Gholami, L., Taheri-Bojd, S., Balali‐Mood, M., Mousavi, S. H., & Malaekeh‐Nikouei, B. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.02.008 · Cited by 41 · see citing works
Quantitative structure-activity relationships for green algae growth inhibition by polymer particles
Nolte, T. M., Peijnenburg, W. J. G. M., Hendriks, A. J., & van de Meent, D. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.03.067 · Cited by 40 · see citing works
Eskandani, M., Vandghanooni, S., Barar, J., Nazemiyeh, H., & Omidi, Y. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.10.113 · Cited by 38 · see citing works
Self-citationBioimpacts of nanoparticle size: why it matters?
Barar, J. (2015) · Bioimpacts · doi:10.15171/bi.2015.23 · Cited by 39 · see citing works
Wang, C., Li, Z., Xu, P., Xu, L. X., Han, S., & Sun, Y. Y. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01689-y · Cited by 38 · see citing works
Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications
Idris, M. I., Zaloga, J., Detsch, R., Roether, J. A., Unterweger, H., Alexiou, C., & Boccaccini, A. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-25243-9 · Cited by 39 · see citing works
Danthanarayana, A. N., Manatunga, D. C., de Silva, R. M., Chandrasekharan, N. V., & de Silva, K. M. N. (2018) · Royal Society Open Science · doi:10.1098/rsos.181369 · Cited by 35 · see citing works
A Novel Aldehyde-Terminated Dendrimers: Synthesis and Cytotoxicity Assay
Hamidi, A., Sharifi, S., Davaran, S., Ghasemi, S., Omidi, Y., & Rashidi, M.-R. (2012) · Tabriz University of Medical Sciences · doi:10.5681/bi.2012.014 · Cited by 34 · see citing works
Self-citationCavuslar, O., Nakay, E., Kazakoglu, U., Abkenar, S. K., Ow-Yang, C., & Acar, H. (2020) · Materials Advances · doi:10.1039/d0ma00404a · Cited by 24 · see citing works
Diaz‐Dussan, D., Nakagawa, Y., Peng, Y., C, L. V. S., Ebara, M., Kumar, P., & Narain, R. (2017) · ACS Macro Letters · doi:10.1021/acsmacrolett.7b00388 · Cited by 33 · see citing works
Magnetic responsive cell-based strategies for diagnostics and therapeutics
Gonçalves, A. I., Miranda, M. S., Rodrigues, M. T., Reis, R. L., & Gomes, M. E. (2018) · Biomedical Materials · doi:10.1088/1748-605x/aac78b · Cited by 33 · see citing works
MicroRNA: Promising Roles in Cancer Therapy
Hashemi, A., & Gorji‐Bahri, G. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666200420101613 · Cited by 33 · see citing works
Karimov, M., Schulz, M., Kahl, T., Noske, S., Kubczak, M., Gockel, I., Thieme, R., Büch, T., Reinert, A., Йонов, М., et al. (2021) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2021.102403 · Cited by 33 · see citing works
Zohri, M., Arefian, E., Javar, H. A., Gazori, T., Aghaee‐Bakhtiari, S. H., Taheri, M., Fatahi, Y., Azadi, A., Khoshayand, M. R., & Ghahremani, M. H. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112262 · Cited by 32 · see citing works
Augustine, J., Cheung, T., Gies, V., Boughton, J., Chen, M., Jakubek, Z. J., Walker, S. B., Martinez‐Rubi, Y., Simard, B., & Zou, S. (2019) · Nanoscale Advances · doi:10.1039/c9na00104b · Cited by 31 · see citing works
Kelly, I. B., Fletcher, R. B., McBride, J. R., Weiss, S. M., & Duvall, C. L. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c05827 · Cited by 32 · see citing works
How does the polymer architecture and position of cationic charges affect cell viability?
Correia, J. S., Mirón‐Barroso, S., Hutchings, C., Ottaviani, S., Somuncuoğlu, B., Castellano, L., Porter, A. E., Krell, J., & Georgiou, T. K. (2022) · Polymer Chemistry · doi:10.1039/d2py01012g · Cited by 30 · see citing works
Brushlike Cationic Polymers with Low Charge Density for Gene Delivery
Ahern, J. O., Sigen, A., Zhou, D., Gao, Y., Lyu, J., Zhao, M., Cutlar, L., Pierucci, L., & Wang, W. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b01267 · Cited by 30 · see citing works
Delivery of RNAi-Based Therapeutics for Bone Regeneration
Malcolm, D. W., Wang, Y., Overby, C. T., Newman, M. R., & Benoit, D. S. W. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00587-2 · Cited by 30 · see citing works
DNA nuclear targeting sequences for enhanced non-viral gene transfer: An in vitro and in vivo study
Guen, Y. T. L., Pichon, C., Guégan, P., Pluchon, K., Haute, T., Quemener, S., Ropars, J., Midoux, P., Gall, T. L., & Montier, T. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.03.012 · Cited by 30 · see citing works
Thambi, T., Hong, J.-W., Yoon, A., & Yun, C. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00469-y · Cited by 29 · see citing works
Phạm, D. T., Saelim, N., Cornu, R., Béduneau, A., & Tiyaboonchai, W. (2020) · Pharmaceuticals · doi:10.3390/ph13050086 · Cited by 29 · see citing works
Noske, S., Karimov, M., Aigner, A. M., & Ewe, A. (2020) · Nanomaterials · doi:10.3390/nano10091809 · Cited by 29 · see citing works
Shih, T., Najibi, A. J., Bartlett, A. L., Li, A. W., & Mooney, D. J. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121240 · Cited by 29 · see citing works
The Interplay of Endosomal Escape and RNA Release from Polymeric Nanoparticles
Cheung, T. H., & Shoichet, M. S. (2025) · Langmuir · doi:10.1021/acs.langmuir.4c05176 · Cited by 32 · see citing works
Monajati, M., Tavakoli, S., Yousefi, G. H., Abolmaali, S. S., & Tamaddon, A. M. (2018) · Bioimpacts · doi:10.15171/bi.2018.27 · Cited by 28 · see citing works
Finding the ideal polyethylenimine-plasmid DNA system for co-delivery of payloads in cancer therapy
Costa, D. R. B., Valente, A. J. M., Queiroz, J. A., & Sousa, Â. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.06.063 · Cited by 28 · see citing works
Costamagna, F., Hillaireau, H., Vergnaud, J., Clarisse, D., Jamgotchian, L., Loreau, O., Denis, S., Gravel, E., Doris, E., & Fattal, E. (2019) · Nanoscale · doi:10.1039/c9nr08714a · Cited by 28 · see citing works
Intrinsic Bio-Signature of Gene Delivery Nanocarriers May Impair Gene Therapy Goals
Barar, J., & Omidi, Y. (2013) · Europe PMC (PubMed Central) · doi:10.5681/bi.2013.028 · Cited by 27 · see citing works
Self-citationPolyethyleneimine-Based Lipopolyplexes as Carriers in Anticancer Gene Therapies
Jerzykiewicz, J., & Czogalla, A. (2021) · Materials · doi:10.3390/ma15010179 · Cited by 27 · see citing works
Kawelah, M. R., Han, S., Dinçer, C. A., Jeon, J., Brisola, J., Hussain, A. F., Jeevarathinam, A. S., Bouchard, R. R., Marras, A. E., Truskett, T. M., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c16584 · Cited by 27 · see citing works
Shin, W., Ambrosini, Y. M., Shin, Y. C., Wu, A. T. H., Min, S., Koh, D., Park, S., Kim, S., Koh, H., & Kim, H. J. (2020) · Frontiers in Medical Technology · doi:10.3389/fmedt.2020.00002 · Cited by 27 · see citing works
Ma, G., Xu, X., Tesfai, M., Wang, H., & Xu, P. (2020) · Journal of Membrane Science · doi:10.1016/j.memsci.2020.118034 · Cited by 26 · see citing works
- Authors
- Kafil, V., & Omidi, Y.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Venue
- Tabriz University of Medical Sciences
- Publisher
- Tabriz University of Medical Sciences
- Published
- 2011
- Volume
- 1
- Issue
- 1
- Pages
- 23-30
- PMC
- PMC3648946
- OpenAlex
- W2098861374
- Cited by
- 215
- References
- 23
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 11 · 2023: 11 · 2022: 18 · 2021: 28 · 2020: 25 · 2019: 24 · 2018: 19 · 2017: 23 · 2016: 9 · 2015: 8 · 2014: 8 · 2013: 9 · 2012: 7
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Tabriz University of Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- polyethyleneimine, branched polyethylenimine, linear polyethylenimine, cytotoxicity, apoptosis, A431 cells, DNA damage, Akt kinase, non-viral gene delivery, nanostructured polymers, cellular internalization
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