The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
p53 in signaling checkpoint arrest or apoptosis
Open accessAbstract
The cell cycle arrest and apoptotic functions of p53 both contribute to the role of this tumour suppressor protein in preventing replication of cells suffering DNA damage. Although the ability of p53 to function as a sequence-specific transcription factor appears to be directly and causally linked to the implementation of an arrest at the G1 stage of the cell cycle, the contribution of transcriptional activation to the apoptotic response is less clear. It seems likely that several p53 activities, both transcriptionally dependent and transcriptionally independent, can play a role in mediating cell death. The requirement for each of these functions appears to depend on the cell type, the cell environment and other genetic alterations already sustained by the cell in which p53 function is activated.
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Cites
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
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p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
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The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
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Radiation-induced cell cycle arrest compromised by p21 deficiency
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p53-Dependent apoptosis suppresses tumor growth and progression in vivo
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Cited by
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312
Self-citation(2002) · PubMed · Cited by 640
Abegglen, L. M., Caulin, A. F., Chan, A., Lee, K., Robinson, R., Campbell, M. S., Kiso, W. K., Schmitt, D. L., Waddell, P. J., Bhaskara, S., et al. (2015) · JAMA · doi:10.1001/jama.2015.13134 · Cited by 485
Regulation of p53 function and stability by phosphorylation.
Ashcroft, M., Kubbutat, M. H. G., & Vousden, K. H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1751 · Cited by 452
Self-citationDifferential Activation of Target Cellular Promoters by p53 Mutants with Impaired Apoptotic Function
Ludwig, R. L., Bates, S., & Vousden, K. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4952 · Cited by 275
Self-citation
Metadata
- Authors
- Bates, S., & Vousden, K. H.
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 1996-02
- Volume
- 6
- Issue
- 1
- Pages
- 12-18
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W1982517685
- Cited by
- 331
- References
- 12
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
