The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Calcium-activated potassium channels
Open accessAbstract
Calcium-activated potassium channels are fundamental regulators of neuronal excitability, participating in interspike interval and spike-frequency adaptation. For large-conductance calcium-activated potassium (BK) channels, recent experiments have illuminated the fundamental biophysical mechanisms of gating, demonstrating that BK channels are voltage gated and calcium modulated. Structurally, BK channels have been shown to possess an extracellular amino-terminal domain, different from other potassium channels. Domains and residues involved in calcium-gating, and perhaps calcium binding itself, have been identified. For small- and intermediate-conductance calcium-activated potassium channels, SK and IK channels, clones have only recently become available, and they show that SK channels are a distinct subfamily of potassium channels. The biophysical properties of SK channels demonstrate that kinetic differences between apamin-sensitive and apamin-insensitive slow afterhyperpolarizations are not attributable to intrinsic gating differences between the two subtypes. Interestingly, SK and IK channels may prove effective drug targets for diseases such as myotonic muscular dystrophy and sickle cell anemia.
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“Cells expressing a Mid1-GFP fusion protein revealed a cell surface distribution of Mid1 that co-localized with Cch1 (Fig. 1B) (24).”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [24]
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Molecular Diversity of K+ Channels
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Ion Channels and Their Functional Role in Vascular Endothelium
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Metadata
- Authors
- Vergara, C., Latorre, R., Marrion, N. V., & Adelman, J. P.
- Affiliations
- University of Chile (CL)
- Oregon Health & Science University (US)
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 8
- Issue
- 3
- Pages
- 321-329
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W1993938009
- Cited by
- 954
- References
- 85
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 10 · 2023: 14 · 2022: 14 · 2021: 14 · 2020: 20 · 2019: 17 · 2018: 16 · 2017: 15 · 2016: 25 · 2015: 28 · 2014: 40 · 2013: 45 · 2012: 28
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- calcium-activated potassium channels, BK channels, small conductance calcium-activated potassium channels, intermediate-conductance calcium-activated potassium channel, IK channels, neuronal excitability, spike frequency adaptation, interspike intervals, voltage-dependent gating, calcium regulation, calcium binding, N-terminal domain, slow afterhyperpolarization, apamin, therapeutic target, myotonic dystrophy, sickle cell disease
- MeSH terms
- Amino Acid Sequence, Calcium, Molecular Sequence Data, Potassium Channels, Signal Transduction, Ion Channel Gating, Protein Structure, Tertiary, Potassium Channels, Calcium-Activated, Large-Conductance Calcium-Activated Potassium Channels
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