Cited by 956Ion channel regulation and functionCardiac electrophysiology and arrhythmiasNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Calcium-activated potassium channels

Open access

Vergara, Cecilia, Latorre, Ramon, Marrion, Neil V, Adelman, John P·1998·Current Opinion in Neurobiology

DOI 10.1016/s0959-4388(98)80056-1

Open this paper in CoChat — free account

Abstract

Calcium-activated potassium channels are fundamental regulators of neuronal excitability, participating in interspike interval and spike-frequency adaptation. For large-conductance calcium-activated potassium (BK) channels, recent experiments have illuminated the fundamental biophysical mechanisms of gating, demonstrating that BK channels are voltage gated and calcium modulated. Structurally, BK channels have been shown to possess an extracellular amino-terminal domain, different from other potassium channels. Domains and residues involved in calcium-gating, and perhaps calcium binding itself, have been identified. For small- and intermediate-conductance calcium-activated potassium channels, SK and IK channels, clones have only recently become available, and they show that SK channels are a distinct subfamily of potassium channels. The biophysical properties of SK channels demonstrate that kinetic differences between apamin-sensitive and apamin-insensitive slow afterhyperpolarizations are not attributable to intrinsic gating differences between the two subtypes. Interestingly, SK and IK channels may prove effective drug targets for diseases such as myotonic muscular dystrophy and sickle cell anemia.

Integrity signals

Registry

Crossref · 10.1016/s0959-4388(98)80056-1

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Stability constants of metal-ion complexes
Sillén, L. G., Martell, A. E., Bjerrum, J., & Schwarzenbach, G. (1964) · Medical Entomology and Zoology · Cited by 3,983
Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation
Hoshi, T., Zagotta, W. N., & Aldrich, R. W. (1990) · Science · doi:10.1126/science.2122519 · Cited by 1,527
Relaxation of Arterial Smooth Muscle by Calcium Sparks
Nelson, M. T., Cheng, H., Rubart, M., Santana, L. F., Bonev, A. D., Knot, H. J., & Lederer, W. J. (1995) · Science · doi:10.1126/science.270.5236.633 · Cited by 1,399
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence
Noda, M., Shimizu, S., Tanabe, T., Takai, T., Kayano, T., Ikeda, T., Takahashi, H., Nakayama, H., Kanaoka, Y., Minamino, N., et al. (1984) · Nature · doi:10.1038/312121a0 · Cited by 1,349
Small-Conductance, Calcium-Activated Potassium Channels from Mammalian Brain
Kohler, M.-L., Hirschberg, B., Bond, C. T., Kinzie, J. M., Marrion, N. V., Maylie, J., & Adelman, J. P. (1996) · Science · doi:10.1126/science.273.5282.1709 · Cited by 946
Self-citation
Ca2+-activated K+ currents in neurones: types, physiological roles and modulation
Sah, P. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80026-9 · Cited by 892
Mutations in the K+ channel signature sequence
Heginbotham, L., Lü, Z., Abramson, T., & MacKinnon, R. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80887-2 · Cited by 853
Varieties of Calcium-Activated Potassium Channels
Latorre, R., Oberhauser, A. F., Labarca, P. P., & Alvarez, O. A. (1989) · Annual Review of Physiology · doi:10.1146/annurev.ph.51.030189.002125 · Cited by 735
Self-citation
The Coupling of Neurotransmitter Receptors to Ion Channels in the Brain
Nicoll, R. A. (1988) · Science · doi:10.1126/science.2456612 · Cited by 729
Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy
Harley, H. G., Brook, J. D., Rundle, S. A., Crow, S., Reardon, W., Buckler, A., Harper, P. S., Housman, D. E., & Shaw, D. J. (1992) · Nature · doi:10.1038/355545a0 · Cited by 725

Show all 85 references

Sorted by citations

Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
Molecular Diversity of K+ Channels
COETZEE, W. A., AMARILLO, Y., CHIU, J., CHOW, A., LAU, D., McCORMACK, T., MORENA, H., NADAL, M. S., OZAITA, A., POUNTNEY, D., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11293.x · Cited by 1,095
On The Cellular and Network Bases of Epileptic Seizures
McCormick, D. A., & Contreras, D. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.815 · Cited by 1,006
Ion Channels and Their Functional Role in Vascular Endothelium
Nilius, B., & Droogmans, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.4.1415 · Cited by 868
Vasoregulation by the β1 subunit of the calcium-activated potassium channel
Brenner, R., Pérez, G. J., Bonev, A. D., Eckman, D. M., Kosek, J. C., Wiler, S. W., Patterson, A. J., Nelson, M. T., & Aldrich, R. W. (2000) · Nature · doi:10.1038/35038011 · Cited by 798
Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin
Schumacher, M. A., Rivard, A. F., Bächinger, H. P., & Adelman, J. P. (2001) · Nature · doi:10.1038/35074145 · Cited by 604
Self-citation
High-conductance potassium channels of the SLO family
Salkoff, L., Butler, A., Ferreira, G., Santi, C. M., & Wei, A. D. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1992 · Cited by 538
Potassium Channels: Molecular Defects, Diseases, and Therapeutic Opportunities
Shieh, C., Coghlan, M. J., Sullivan, J. P., & Gopalakrishnan, M. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01469-8 · Cited by 519
Channels underlying neuronal calcium-activated potassium currents
Sah, P., & Faber, E. S. L. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00004-7 · Cited by 512
Acute Activation of Maxi-K Channels ( hSlo ) by Estradiol Binding to the β Subunit
Valverde, M. A., Rojas, P., Amigo, J. D., Cosmelli, D. J., Orio, P., Bahamonde, M. I., Mann, G. E., Vergara, C., & Latorre, R. (1999) · Science · doi:10.1126/science.285.5435.1929 · Cited by 511
Self-citation
Coupling between Voltage Sensor Activation, Ca2+ Binding and Channel Opening in Large Conductance (BK) Potassium Channels
Horrigan, F. T., & Aldrich, R. W. (2002) · The Journal of General Physiology · doi:10.1085/jgp.20028605 · Cited by 497
Overview of Molecular Relationships in the Voltage-Gated Ion Channel Superfamily
Yu, F. H., Yarov-Yarovoy, V. M., Gutman, G. A., & Catterall, W. A. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.13 · Cited by 495
Calcium-activated potassium channels expressed from cloned complementary DNAs
Adelman, J. P., Shen, K., Kavanaugh, M. P., Warren, R. A., Wu, Y.-N., Lagrutta, A., Bond, C. T., & North, R. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90160-f · Cited by 493
Self-citation
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis
Yu, F. H., & Catterall, W. A. (2004) · Science s STKE · doi:10.1126/stke.2532004re15 · Cited by 488
Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior
Peters, H., Hu, H., Pongs, O., Storm, J. F., & Isbrandt, D. (2004) · Nature Neuroscience · doi:10.1038/nn1375 · Cited by 421
Physiological roles of K+ channels in vascular smooth muscle cells
Ko, E. A., Han, J., Jung, I. D., & Park, W. S. (2008) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.44.65 · Cited by 410
Differential Distribution of Three Ca2+-Activated K+ Channel Subunits, SK1, SK2, and SK3, in the Adult Rat Central Nervous System
Stocker, M., & Pedarzani, P. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0842 · Cited by 374
BK Ca -Cav Channel Complexes Mediate Rapid and Localized Ca 2+ -Activated K + Signaling
Berkefeld, H., Sailer, C. A., Bildl, W., Rohde, V., Thumfart, J. O., Eble, S., Klugbauer, N., Reisinger, E., Bischofberger, J., Oliver, D., et al. (2006) · Science · doi:10.1126/science.1132915 · Cited by 374
Control of KCa Channels by Calcium Nano/Microdomains
Fakler, B., & Adelman, J. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.001 · Cited by 369
Self-citation
Cell volume regulation: osmolytes, osmolyte transport, and signal transduction
Wehner, F., Olsen, H. B., Tinel, H., Kinne-Saffran, E., & Kinne, R. K. H. (2003) · Springer eBooks · doi:10.1007/s10254-003-0009-x · Cited by 371
Differential Expression of the Small-Conductance, Calcium-Activated Potassium Channel SK3 Is Critical for Pacemaker Control in Dopaminergic Midbrain Neurons
Wolfart, J., Neuhoff, H., Franz, O., & Roeper, J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03443.2001 · Cited by 345
Mechanisms Underlying Spontaneous Oscillation and Rhythmic Firing in Rat Subthalamic Neurons
Bevan, M. D., & Wilson, C. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07617.1999 · Cited by 343
Presynaptic Ca2+-Activated K+Channels in Glutamatergic Hippocampal Terminals and Their Role in Spike Repolarization and Regulation of Transmitter Release
Hu, H., Shao, L.-R., Chavoshy, S., Gu, N., Trieb, M., Behrens, R., Laake, P., Pongs, O., Knaus, H., Ottersen, O. P., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09585.2001 · Cited by 340
Alternative RNA splicing in the nervous system
Grabowski, P. J., & Black, D. L. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00007-7 · Cited by 336
Calmodulin's Flexibility Allows for Promiscuity in Its Interactions with Target Proteins and Peptides
Yamniuk, A. P., & Vogel, H. J. (2004) · Molecular Biotechnology · doi:10.1385/mb:27:1:33 · Cited by 322
Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
Gribkoff, V. K., Starrett, J. E., Dworetzky, S. I., Hewawasam, P., Boissard, C. G., Cook, D. A., Frantz, S. W., Heman, K. L., Hibbard, J. R., Huston, K., et al. (2001) · Nature Medicine · doi:10.1038/86546 · Cited by 312
Oxygen sensing in the body
Lahiri, S., Roy, A., Baby, S. M., Hoshi, T., Semenza, G. L., & Prabhakar, N. R. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2005.07.001 · Cited by 312
BK potassium channels facilitate high‐frequency firing and cause early spike frequency adaptation in rat CA1 hippocampal pyramidal cells
Gu, N., Vervaeke, K., & Storm, J. F. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.126367 · Cited by 294
hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large‐conductance calcium‐activated potassium channel β subunit family
Behrens, R., Nolting, A., Reimann, F. M., SCHWARZ, M., Waldschütz, R., & Pongs, O. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01584-2 · Cited by 285
New Disguises for an Old Channel: MaxiK Channel β-Subunits
Orio, P., Rojas, P., Ferreira, G., & Latorre, R. (2002) · Physiology · doi:10.1152/nips.01387.2002 · Cited by 285
Self-citation
Molecular Identification and Functional Roles of a Ca2+-activated K+ Channel in Human and Mouse Hearts
Xu, Y., Tuteja, D., Zhang, Z., Xu, D., Zhang, Y., Rodriguez, J., Nie, L., Tuxson, H. R., Young, J. N., Glatter, K. A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307508200 · Cited by 281
Intrinsic Voltage Dependence and Ca2+ Regulation of mslo Large Conductance Ca-activated K+ Channels
Cui, J., Cox, D. H., & Aldrich, R. W. (1997) · The Journal of General Physiology · doi:10.1085/jgp.109.5.647 · Cited by 279
Ancillary Subunits Associated With Voltage-Dependent K + Channels
Pongs, O., & Schwarz, J. R. (2010) · Physiological Reviews · doi:10.1152/physrev.00020.2009 · Cited by 274
Calcium-Activated Potassium Channels: Multiple Contributions to Neuronal Function
Faber, E. S. L., & Sah, P. (2003) · The Neuroscientist · doi:10.1177/1073858403009003011 · Cited by 267
Potassium channels and pain: present realities and future opportunities
Ocaña, M., Cendán, C. M., Cobos, E. J., Entrena, J. M., & Baeyens, J. M. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.026 · Cited by 266
Unique Roles of SK and Kv4.2 Potassium Channels in Dendritic Integration
Cai, X., Liang, C. W., Muralidharan, S., Kao, J. P. Y., Tang, C., & Thompson, S. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.026 · Cited by 266
Molecular Basis for the Inactivation of Ca 2+ - and Voltage-Dependent BK Channels in Adrenal Chromaffin Cells and Rat Insulinoma Tumor Cells
Xia, X., Ding, J. P., & Lingle, C. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05255.1999 · Cited by 260
Allosteric Gating of a Large Conductance Ca-activated K+ Channel
Cox, D. H., Cui, J., & Aldrich, R. W. (1997) · The Journal of General Physiology · doi:10.1085/jgp.110.3.257 · Cited by 258
Ca2+-Activated K+Channels: From Protein Complexes to Function
Berkefeld, H., Fakler, B., & Schulte, U. (2010) · Physiological Reviews · doi:10.1152/physrev.00049.2009 · Cited by 274
Correlation Maps Allow Neuronal Electrical Properties to be Predicted from Single-cell Gene Expression Profiles in Rat Neocortex
Toledo-Rodriguez, M. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh092 · Cited by 241
Cardiac Potassium Channel Subtypes: New Roles in Repolarization and Arrhythmia
Schmitt, N., Grunnet, M., & Olesen, S. (2014) · Physiological Reviews · doi:10.1152/physrev.00022.2013 · Cited by 240
Cloning and Functional Expression of Two Families of β-Subunits of the Large Conductance Calcium-activated K+ Channel
Uebele, V. N., Lagrutta, A., Wade, T., Figueroa, D. J., Liu, Y., McKenna, E. J., Austin, C. P., Bennett, P. B., & Swanson, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910187199 · Cited by 240
Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function
Edgerton, J. R., & Reinhart, P. H. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00053.x · Cited by 237
Afferent modulation of dopamine neuron firing patterns
Kitai, S. T., Shepard, P. D., Callaway, J. C., & Scroggs, R. S. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00040-9 · Cited by 234
Physiological Role of Calcium-Activated Potassium Currents in the Rat Lateral Amygdala
Faber, E. S. L., & Sah, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01618.2002 · Cited by 234
Fourier Analysis of Sinusoidally Driven Thalamocortical Relay Neurons and a Minimal Integrate-and-Fire-or-Burst Model
Smith, G. D., Cox, C. L., Sherman, S. M., & Rinzel, J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.1.588 · Cited by 232
Differential expression of small-conductance Ca2+-activated K+channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes
Tuteja, D., Xu, D., Timofeyev, V., Lü, L., Sharma, D., Zhang, Z., Xu, Y., Nie, L., Vázquez, A. E., Young, J. N., et al. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00534.2005 · Cited by 233
Characterization of an apamin‐sensitive small‐conductance Ca2+‐activated K+ channel in porcine coronary artery endothelium: relevance to EDHF
Burnham, M. P., Bychkov, R., Félétou, M., Richards, G. R., Vanhoutte, P. M., Weston, A. H., & Edwards, G. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704551 · Cited by 229
Role of the β1 Subunit in Large-Conductance Ca2+-Activated K+ Channel Gating Energetics
Cox, D. H., & Aldrich, R. W. (2000) · The Journal of General Physiology · doi:10.1085/jgp.116.3.411 · Cited by 226
Ion dynamics during seizures
Raimondo, J. V., Burman, R. J., Katz, A. A., & Akerman, C. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00419 · Cited by 224
Localization of the Slack potassium channel in the rat central nervous system
Bhattacharjee, A., Gan, L., & Kaczmarek, L. K. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10439 · Cited by 213
Apamin-Sensitive Small Conductance Calcium-Activated Potassium Channels, through their Selective Coupling to Voltage-Gated Calcium Channels, Are Critical Determinants of the Precision, Pace, and Pattern of Action Potential Generation in Rat Subthalamic Nucleus Neurons In Vitro
Hallworth, N. E., Wilson, C. J., & Bevan, M. D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07525.2003 · Cited by 210
Comparative Morphology of Rodent Vestibular Periphery. I. Saccular and Utricular Maculae
Desai, S. S., Zeh, C., & Lysakowski, A. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00746.2003 · Cited by 209
Alternative Splicing Switches Potassium Channel Sensitivity to Protein Phosphorylation
Tian, L., Duncan, R. R., Hammond, M. S. L., Coghill, L. S., Wen, H., Rusinova, R., Clark, A. G., Levitan, I. B., & Shipston, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000741200 · Cited by 208
Molecular mechanisms of BK channel activation
Cui, J., Yang, H., & Lee, U. S. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8609-x · Cited by 206
Ion channels in the RPE
WIMMERS, S., KARL, M., & STRAUSS, O. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.12.002 · Cited by 207
Ablation of a Ca2+‐activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation
Li, N., Timofeyev, V., Tuteja, D., Xu, D., Lü, L., Zhang, Q., Zhang, Z., Singapuri, A., Albert, T. R., Rajagopal, A., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.167718 · Cited by 202
Self-citation
Regional Differences in Distribution and Functional Expression of Small-Conductance Ca2+-Activated K+Channels in Rat Brain
Sailer, C. A., Hu, H., Kaufmann, W. A., Trieb, M., Schwarzer, C., Storm, J. F., & Knaus, H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09698.2002 · Cited by 202
The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation
Finnie, P. S. B., & Nader, K. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.03.008 · Cited by 189
Mechanisms underlying the early phase of spike frequency adaptation in mouse spinal motoneurones
Miles, G. B., Dai, Y., & Brownstone, R. M. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.086033 · Cited by 189
Gating Mechanism of BK (Slo1) Channels
Magleby, K. L. (2003) · The Journal of General Physiology · doi:10.1085/jgp.20028721 · Cited by 194
Allosteric Voltage Gating of Potassium Channels II
Horrigan, F. T., & Aldrich, R. W. (1999) · The Journal of General Physiology · doi:10.1085/jgp.114.2.305 · Cited by 188
BK potassium channels control transmitter release at CA3–CA3 synapses in the rat hippocampus
Raffaelli, G., Saviane, C., Mohajerani, M. H., Pedarzani, P., & Cherubini, E. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.062661 · Cited by 191
Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits
Joiner, W. J., Tang, M. D., Wang, L., Dworetzky, S. I., Boissard, C. G., Gan, L., Gribkoff, V. K., & Kaczmarek, L. K. (1998) · Nature Neuroscience · doi:10.1038/2176 · Cited by 191
Somatic and Dendritic Small-Conductance Calcium-Activated Potassium Channels Regulate the Output of Cerebellar Purkinje Neurons
Womack, M. D., & Khodakhah, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02600.2003 · Cited by 189
Molecular Cloning and Characterization of the Intermediate-Conductance Ca 2+ -Activated K + Channel in Vascular Smooth Muscle
Neylon, C. B., Lang, R. J., Fu, Y. H., Bobik, A., & Reinhart, P. H. (1999) · Circulation Research · doi:10.1161/01.res.85.9.e33 · Cited by 186
Cellular and molecular connections between sleep and synaptic plasticity
Benington, J. H., & Frank, M. G. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00018-2 · Cited by 244
Pharmacological characterization of small‐conductance Ca2+‐activated K+ channels stably expressed in HEK 293 cells
Strøbæk, D., Dyhring, T., Christophersen, P., Ahring, P. K., & Olesen, S. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703120 · Cited by 181
Sarcoplasmic Reticulum Function in Smooth Muscle
Wray, S., & Burdyga, T. V. (2010) · Physiological Reviews · doi:10.1152/physrev.00018.2008 · Cited by 186
Elevated subsarcolemmal Ca 2+ in mdx mouse skeletal muscle fibers detected with Ca 2+ -activated K + channels
Mallouk, N., Jacquemond, V., & Allard, B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4950 · Cited by 168
Mutational analysis of dendritic Ca2+ kinetics in rodent Purkinje cells: role of parvalbumin and calbindin D28k
Schmidt, H., Stiefel, K. M., Račay, P., Schwaller, B., & Eilers, J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.035824 · Cited by 168
Role of Charged Residues in the S1–S4 Voltage Sensor of BK Channels
Ma, Z., Lou, X. J., & Horrigan, F. T. (2006) · The Journal of General Physiology · doi:10.1085/jgp.200509421 · Cited by 164
Cloning and Characterization of Glioma BK, a Novel BK Channel Isoform Highly Expressed in Human Glioma Cells
Liu, X., Chang, Y., Reinhart, P. H., & Sontheimer, H. W. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01840.2002 · Cited by 162
Rectification and Rapid Activation at Low Ca2+of Ca2+-Activated, Voltage-Dependent BK Currents: Consequences of Rapid Inactivation by a Novel β Subunit
Xia, X., Ding, J., Zeng, X.-H., Duan, K., & Lingle, C. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-13-04890.2000 · Cited by 161
K+ channels as therapeutic drug targets
Wickenden, A. D. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00201-2 · Cited by 160
Nitric oxide in shock
Cauwels, A. (2007) · Kidney International · doi:10.1038/sj.ki.5002340 · Cited by 156
Edit, cut and paste in the nicotinic acetylcholine receptor gene family ofDrosophila melanogaster
Sattelle, D. B., Jones, A. K., Sattelle, B. M., Matsuda, K., Reenan, R. A., & Biggin, P. C. (2005) · BioEssays · doi:10.1002/bies.20207 · Cited by 158
Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sites
Özgen, N., Dun, W., Sosunov, E. A., Anyukhovsky, E. P., HIROSE, M., Duffy, H. S., Boyden, P. A., & ROSEN, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.008 · Cited by 157
Ca2+-activated K+ channels of the BK-type in the mouse brain
Sausbier, U., Sausbier, M., Sailer, C. A., Arntz, C., Knaus, H., Neuhuber, W., & Ruth, P. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0124-7 · Cited by 157
Large conductance Ca2+-activated K+ (BK) channel: Activation by Ca2+ and voltage
Latorre, R., & Brauchi, S. E. (2006) · Biological Research · doi:10.4067/s0716-97602006000300003 · Cited by 156
Self-citation
Molecular basis and function of voltage-gated K+channels in pulmonary arterial smooth muscle cells
Yuan, X.-J., Wang, J., Juhaszova, M., Golovina, V. A., & Rubin, L. J. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.4.l621 · Cited by 156
BK channel activators and their therapeutic perspectives
Bentzen, B. H., Olesen, S., Rønn, L. C. B., & Grunnet, M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00389 · Cited by 151
Natural courtship song variation caused by an intronic retroelement in an ion channel gene
Ding, Y., Berrocal, A., Morita, T., Longden, K. D., & Stern, D. L. (2016) · Nature · doi:10.1038/nature19093 · Cited by 151
Characterization of Elementary Ca2+ Release Signals in NGF-Differentiated PC12 Cells and Hippocampal Neurons
Koizumi, S., Bootman, M. D., Bobanović, L. K., Schell, M. J., Berridge, M. J., & Lipp, P. (1999) · Neuron · doi:10.1016/s0896-6273(00)80684-4 · Cited by 151
Voltage and Ca2+ Activation of Single Large-Conductance Ca2+-Activated K+ Channels Described by a Two-Tiered Allosteric Gating Mechanism
Rothberg, B. S., & Magleby, K. L. (2000) · The Journal of General Physiology · doi:10.1085/jgp.116.1.75 · Cited by 149
The Making of a Complex Spike: Ionic Composition and Plasticity
SCHMOLESKY, M. T., Weber, J. T., Zeeuw, C. I. D., & Hansel, C. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb07581.x · Cited by 149
Regulation of Firing Response Gain by Calcium-Dependent Mechanisms in Vestibular Nucleus Neurons
Smith, M. R., Nelson, A., & du Lac, S. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00821.2001 · Cited by 147
The Two-pore Domain K+ Channel, TRESK, Is Activated by the Cytoplasmic Calcium Signal through Calcineurin
Czirják, G., Tóth, Z., & Enyedi, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312229200 · Cited by 147
Redox Modulation ofhsloCa2+-Activated K+Channels
DiChiara, T. J., & Reinhart, P. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-04942.1997 · Cited by 146
Opposite Actions of Brain-Derived Neurotrophic Factor and Neurotrophin-3 on Firing Features and Ion Channel Composition of Murine Spiral Ganglion Neurons
Adamson, C. L., Reid, M. A., & Davis, R. L. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01385.2002 · Cited by 146
Molecular Coupling of a Ca 2+ -Activated K + Channel to L-Type Ca 2+ Channels via α-Actinin2
Lü, L., Zhang, Q. Y., Timofeyev, V., Zhang, Z., Young, J. N., Shin, H., Knowlton, A. A., & Chiamvimonvat, N. (2006) · Circulation Research · doi:10.1161/01.res.0000253095.44186.72 · Cited by 145
K+ Channels in Apoptosis
Burg, E. D., Remillard, C. V., & Yuan, J. X. ‐. (2006) · The Journal of Membrane Biology · doi:10.1007/s00232-005-0838-4 · Cited by 145
Modulation of BKCaChannel Gating by Endogenous Signaling Molecules
Hou, S., Heinemann, S. H., & Hoshi, T. (2009) · Physiology · doi:10.1152/physiol.00032.2008 · Cited by 143
Glutamate-Mediated Extrasynaptic Inhibition
Isaacson, J. S., & Murphy, G. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00428-7 · Cited by 144
Regulation of Synaptic Transmission by Presynaptic CaMKII and BK Channels
Wang, Z. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8039-7 · Cited by 142
A Novel Nervous System β Subunit that Downregulates Human Large Conductance Calcium-Dependent Potassium Channels
Weiger, T. M., Holmqvist, M., Levitan, I. B., Clark, F. T., Sprague, S., Huang, W.-J., Ge, P., Wang, C., Lawson, D., Jurman, M. E., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03563.2000 · Cited by 126
Divalent Cation Sensitivity of BK Channel Activation Supports the Existence of Three Distinct Binding Sites
Zeng, X., Xia, X., & Lingle, C. J. (2005) · The Journal of General Physiology · doi:10.1085/jgp.200409239 · Cited by 142
Transplantable sites confer calcium sensitivity to BK channels
Schreiber, M. A., Yuan, A., & Salkoff, L. (1999) · Nature Neuroscience · doi:10.1038/8077 · Cited by 142
Recent Developments in the Biology and Medicinal Chemistry of Potassium Channel Modulators: Update from a Decade of Progress
Coghlan, M. J., Carroll, W. A., & Gopalakrishnan, M. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm000484+ · Cited by 138
Caveolae Targeting and Regulation of Large Conductance Ca2+-activated K+ Channels in Vascular Endothelial Cells
Wang, X.-L., Ye, D., Peterson, T. E., Cao, S., Shah, V. H., Katušić, Z. S., Sieck, G. C., & Lee, H.-C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410987200 · Cited by 137

Authors: Vergara, C., Latorre, R., Marrion, N. V., & Adelman, J. P.
Affiliations: University of Chile (CL)
Oregon Health & Science University (US)
ORCID: Vergara, Cecilia
Marrion, Neil V
Adelman, John P
Venue: Current Opinion in Neurobiology
Publisher: Elsevier BV
Published: 1998-06
Volume: 8
Issue: 3
Pages: 321-329
ISSN: 0959-4388 (ISSN-L)
DOI: 10.1016/s0959-4388(98)80056-1
OpenAlex: W1993938009
Cited by: 954
References: 85
Citations by year: 2026: 10 · 2025: 17 · 2024: 10 · 2023: 14 · 2022: 14 · 2021: 14 · 2020: 20 · 2019: 17 · 2018: 16 · 2017: 15 · 2016: 25 · 2015: 28 · 2014: 40 · 2013: 45 · 2012: 28
FWCI: 3.38
Type: journal article
Language: en
Open access: green
repositorio.uchile.cl
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Universidad de Chile (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: calcium-activated potassium channels, BK channels, small conductance calcium-activated potassium channels, intermediate-conductance calcium-activated potassium channel, IK channels, neuronal excitability, spike frequency adaptation, interspike intervals, voltage-dependent gating, calcium regulation, calcium binding, N-terminal domain, slow afterhyperpolarization, apamin, therapeutic target, myotonic dystrophy, sickle cell disease
MeSH terms: Amino Acid Sequence, Calcium, Molecular Sequence Data, Potassium Channels, Signal Transduction, Ion Channel Gating, Protein Structure, Tertiary, Potassium Channels, Calcium-Activated, Large-Conductance Calcium-Activated Potassium Channels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Calcium-activated potassium channels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks