Cited by 173Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias

Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain

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Pedarzani, P., Stocker, M.·2008·Cellular and Molecular Life Sciences

Abstract

Small conductance calcium-activated potassium (SK or K(Ca)2) channels link intracellular calcium transients to membrane potential changes. SK channel subtypes present different pharmacology and distribution in the nervous system. The selective blocker apamin, SK enhancers and mice lacking specific SK channel subunits have revealed multifaceted functions of these channels in neurons, glia and cerebral blood vessels. SK channels regulate neuronal firing by contributing to the afterhyperpolarization following action potentials and mediating I(AHP), and partake in a calcium-mediated feedback loop with NMDA receptors, controlling the threshold for induction of hippocampal long-term potentiation. The function of distinct SK channel subtypes in different neurons often results from their specific coupling to different calcium sources. The prominent role of SK channels in the modulation of excitability and synaptic function of limbic, dopaminergic and cerebellar neurons hints at their possible involvement in neuronal dysfunction, either as part of the causal mechanism or as potential therapeutic targets.

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  1. [228]Meissner B. Purmann S. Schurmann M. Zuhlke C. Lencer R. Arolt V. Muller-Myhsok B. Morris-Rosendahl D. J. Schwinger E. hSKCa3: A candidate gene for schizophrenia? Psychiatr. Genet. 1999 9 91 96 10412188
  2. [235]Rohrmeier T. Putzhammer A. Schoeler A. Sartor H. Dallinger P. Nothen M. M. Propping P. Knapp M. Albus M. Borrmann M. Knothe K. Kreiner R. Franzek E. Lichtermann D. Rietschel M. Maier W. Klein H. E. Eichhammer P. hSKCa3: No association of the polymorphic CAG repeat with bipolar affective disorder and schizophrenia Psychiatr. Genet. 1999 9 169 175 10697822

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Authors
Pedarzani, P., & Stocker, M.
Affiliations
University College London (GB)
Corresponding author
Pedarzani, P.
Venue
Cellular and Molecular Life Sciences
Published
2008-07-04
Volume
65
Issue
20
Pages
3196-3217
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W2033849297
Cited by
173
References
266
Citations by year
2026: 4 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 11 · 2021: 5 · 2020: 11 · 2019: 10 · 2018: 4 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 14 · 2013: 12 · 2012: 22
FWCI
1.34
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Life Sciences (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Wellcome Trust
  • Medical Research Council
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
small conductance calcium-activated potassium channels, intermediate-conductance calcium-activated potassium channel, apamin, afterhyperpolarization, hippocampal long-term potentiation, neuronal excitability, calcium signaling, glia, cerebral vasculature, synaptic function, dopaminergic neurons, cerebellar neurons, neuronal dysfunction, therapeutic target
MeSH terms
Amino Acid Sequence, Animals, Mental Disorders, Brain, Humans, Molecular Sequence Data, Neurons, Small-Conductance Calcium-Activated Potassium Channels, Intermediate-Conductance Calcium-Activated Potassium Channels

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