Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain
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Small conductance calcium-activated potassium (SK or K(Ca)2) channels link intracellular calcium transients to membrane potential changes. SK channel subtypes present different pharmacology and distribution in the nervous system. The selective blocker apamin, SK enhancers and mice lacking specific SK channel subunits have revealed multifaceted functions of these channels in neurons, glia and cerebral blood vessels. SK channels regulate neuronal firing by contributing to the afterhyperpolarization following action potentials and mediating I(AHP), and partake in a calcium-mediated feedback loop with NMDA receptors, controlling the threshold for induction of hippocampal long-term potentiation. The function of distinct SK channel subtypes in different neurons often results from their specific coupling to different calcium sources. The prominent role of SK channels in the modulation of excitability and synaptic function of limbic, dopaminergic and cerebellar neurons hints at their possible involvement in neuronal dysfunction, either as part of the causal mechanism or as potential therapeutic targets.
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Small-conductance calcium-activated potassium (SK) channels have been reported to control spontaneous firing regularity both in vivo and in vitro.
“Particularly, small-conductance calcium-activated potassium (SK) channels have been reported to control the spontaneous firing regularity both in vivo and in vitro [80, 81].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [80]
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- [235]Rohrmeier T. Putzhammer A. Schoeler A. Sartor H. Dallinger P. Nothen M. M. Propping P. Knapp M. Albus M. Borrmann M. Knothe K. Kreiner R. Franzek E. Lichtermann D. Rietschel M. Maier W. Klein H. E. Eichhammer P. hSKCa3: No association of the polymorphic CAG repeat with bipolar affective disorder and schizophrenia Psychiatr. Genet. 1999 9 169 175 10697822
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- Authors
- Pedarzani, P., & Stocker, M.
- Affiliations
- University College London (GB)
- Corresponding author
- Pedarzani, P.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2008-07-04
- Volume
- 65
- Issue
- 20
- Pages
- 3196-3217
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC2798969
- OpenAlex
- W2033849297
- Cited by
- 173
- References
- 266
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- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cellular and Molecular Life Sciences (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- small conductance calcium-activated potassium channels, intermediate-conductance calcium-activated potassium channel, apamin, afterhyperpolarization, hippocampal long-term potentiation, neuronal excitability, calcium signaling, glia, cerebral vasculature, synaptic function, dopaminergic neurons, cerebellar neurons, neuronal dysfunction, therapeutic target
- MeSH terms
- Amino Acid Sequence, Animals, Mental Disorders, Brain, Humans, Molecular Sequence Data, Neurons, Small-Conductance Calcium-Activated Potassium Channels, Intermediate-Conductance Calcium-Activated Potassium Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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