Cited by 151Protein Structure and DynamicsProtein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

The modular logic of signaling proteins: building allosteric switches from simple binding domains

Lim, Wendell A·2002·Current Opinion in Structural Biology

Abstract

Many eukaryotic signal transduction proteins have component-based architectures: they are built from combinations of protein interaction domains and catalytic domains. Intact, these proteins display the sophisticated allosteric behavior required for cellular regulation; the protein's output activity is tightly repressed under basal conditions, but can be robustly activated by a specific set of input effector ligands. A combination of structural, biophysical and computational studies is beginning to shed light on the fundamental principles governing this type of modular allostery.

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Crossref · 10.1016/s0959-440x(02)00290-7

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52 of 52 references verified0 citation errors · 0 not checkable

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Authors
Lim, W. A.
Affiliations
University of California, San Francisco (US)
Corresponding author
Lim, Wendell A
Venue
Current Opinion in Structural Biology
Publisher
Elsevier BV
Published
2002-02
Volume
12
Issue
1
Pages
61-68
ISSN
0959-440X (ISSN-L)
OpenAlex
W2021209514
Cited by
151
References
52
Citations by year
2026: 3 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 9
FWCI
0.89
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Structural Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
allosteric regulation, signal transduction proteins, protein-protein interaction domains, catalytic domain, binding domain, protein structure-function relationship
MeSH terms
Allosteric Regulation, Allosteric Site, Animals, Binding Sites, Humans, Ligands, Protein Conformation, Proteins, Thermodynamics, Signal Transduction, Protein Structure, Tertiary, src-Family Kinases, Wiskott-Aldrich Syndrome Protein

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