Cited by 199Head and Neck Cancer StudiesCancer survivorship and careInflammatory Biomarkers in Disease Prognosis

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Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer

de Graeff, A, de Leeuw, J.R.J, Ros, W.J.G, Hordijk, G.J, Blijham, G.H, Winnubst, J.A.M·2001·European Journal of Cancer

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Abstract

Pre-treatment quality of life (QOL) has been found to be an independent prognostic factor for survival in cancer patients, in particular in patients with advanced cancer. Sociodemographic factors such as marital and socioeconomic status have also been recognised as prognostic factors. We studied the influence of QOL and mood (measured with the European Organization for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) and the Head and Neck Cancer Questionnaire (EORTC QLQ-H&N35), and with the Center for Epidemiologic Studies-Depression Scale (CES-D)) as measured before treatment, the use of cigarettes and alcohol and sociodemographic factors (age, gender, marital status, income and occupation) on recurrence and survival in 208 patients with head and neck cancer prior to treatment with surgery and/or radiotherapy, using Kaplan-Meier and Cox regression analyses. Cognitive functioning and, to a lesser degree, marital status were independent predictors of recurrence and survival, along with medical factors (stage and radicality). Patients with less than optimal cognitive functioning and unmarried patients had a relative risk (RR) of recurrence of 1.72 (95% confidence interval (95% CI) 1.01-2.93) and 1.85 (95% CI 1.06-3.33), respectively, and a RR of dying of 1.90 (95% CI 1.10-3.26) and 1.82 (95% CI 1.03-3.23), respectively. Performance status, physical functioning, mood and global QOL and smoking and drinking did not predict for recurrence and survival. The influence of cognitive functioning might be related to the use of alcohol. Marital status may influence prognosis through mechanisms of health behaviour and/or social support mechanisms.

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Background
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Authors: de Graeff, A., de Leeuw, J. R. J., Ros, W. J. G., Hordijk, G. J., Blijham, G. H., & Winnubst, J. A. M.
Affiliations: University Medical Center Utrecht (NL)
ORCID: Ros, W.J.G
Venue: European Journal of Cancer
Publisher: Elsevier BV
Published: 2001-02
Volume: 37
Issue: 3
Pages: 332-339
ISSN: 0959-8049 (ISSN-L)
DOI: 10.1016/s0959-8049(00)00385-3
OpenAlex: W2080391410
Cited by: 199
References: 51
Citations by year: 2026: 4 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 12 · 2021: 2 · 2020: 3 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 12 · 2013: 7 · 2012: 11
FWCI: 8.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Health Sciences › Medicine › Oncology › Cancer survivorship and care
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords: head and neck cancer, quality of life, prognostic factors, recurrence, survival, sociodemographic factors, marital status, cognitive function, mood, depression, smoking, alcohol consumption, socioeconomic status, EORTC QLQ-H&N35, EORTC QLQ-C30, social support
MeSH terms: Alcohol Drinking, Female, Head and Neck Neoplasms, Humans, Male, Neoplasm Recurrence, Local, Prognosis, Prospective Studies, Quality of Life, Risk Factors, Smoking, Socioeconomic Factors, Multivariate Analysis, Survival Analysis

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Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer

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