Platelet-derived growth factor is constitutively secreted from neuronal cell bodies but not from axons
Open accessAbstract
Neurons synthesise and secrete many growth and survival factors but it is not usually clear whether they are released locally at the cell body or further afield from axons or axon terminals. Without this information, we cannot predict the site(s) of action or the biological functions of many neuron-derived factors. For example, can neuronal platelet-derived growth factor (PDGF) be secreted from axons and reach glial cells in nerve-fibre (white-matter) tracts? To address this question, we expressed PDGF-A in retinal ganglion neurons in transgenic mice and tested for release of PDGF from cell bodies in the retina and from axons in the optic nerve. In both the retina and optic nerve, there are glial cells that express PDGF receptor alpha (PDGFR alpha) [1] and divide in response to PDGF [2-5], so we could detect functional PDGF indirectly through the mitogenic response of glia at both locations. Expressing PDGF-A in neurons under the control of the neuron-specific enolase promoter (NSE-PDGF-A) resulted in a striking hyperplasia of retinal astrocytes, demonstrating that PDGF is secreted from the cell bodies of neurons in the retina [4]. In contrast, glial proliferation in the optic nerve was unaffected, indicating that PDGF is not released from axons. When PDGF was expressed directly in the optic nerve under the control of an astrocyte-specific promoter (GFAP-PDGF-A), oligodendrocyte progenitors hyperproliferated, resulting in a hypertrophic optic nerve. We conclude that PDGF is constitutively secreted from neuronal cell bodies in vivo, but not from axons in white-matter tracts.
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Pdgf-AA is released from neuronal cell bodies in the retina but not from their axons in the optic nerve.
“Against this idea, we showed previously that an important neuron-derived OP mitogen, platelet-derived growth factor (A-chain homodimers, Pdgf-AA), is released from neuronal cell bodies in the retina but not from their axons in the optic nerve (Fruttiger et al., 2000).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Fruttiger et al., 2000
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- Authors
- Fruttiger, M., Calver, A. R., & Richardson, W. D.
- Affiliations
- University College London (GB)
- GlaxoSmithKline (United Kingdom) (GB)
- Corresponding author
- Fruttiger, Marcus
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 10
- Issue
- 20
- Pages
- 1283-1286
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2125294887
- Cited by
- 81
- References
- 19
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 8 · 2014: 3 · 2013: 7 · 2012: 5
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- platelet-derived growth factor, PDGF-A, neuronal cell bodies, axons, axon terminals, retinal ganglion cells, optic nerve, retinal astrocytes, oligodendrocyte progenitors, glial cell proliferation, PDGFRA, neuron-specific enolase promoter, GFAP promoter, white matter tracts, transgenic mice
- MeSH terms
- Animals, Astrocytes, Axons, Cell Division, Humans, Hyperplasia, Mice, Transgenic, Neuroglia, Neurons, Oligodendroglia, Optic Nerve, Phosphopyruvate Hydratase, Platelet-Derived Growth Factor, Promoter Regions, Genetic, Retina, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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