The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Dynamin 3 Is a Component of the Postsynapse, Where it Interacts with mGluR5 and Homer
Open accessAbstract
The dynamins comprise a large family of mechanoenzymes known to participate in membrane modeling events. All three conventional dynamin genes (Dyn1, Dyn2, Dyn3) are expressed in mammalian brain and produce more than 27 different dynamin proteins as a result of alternative splicing. Past studies have suggested that Dyn1 participates in specialized neuronal functions such as rapid synaptic vesicle recycling, while Dyn2 may mediate the conventional clathrin-mediated uptake of surface receptors. Currently, the distribution, expression, and function of Dyn3 in neurons, or in any other cell type, are completely undefined. Here, we demonstrate that Dyn1 and Dyn3 localize differentially in the synapse. Dyn1 concentrates within the presynaptic compartment, while Dyn3 localizes to dendritic spine tips. Within the postsynaptic density (PSD), we found Dyn3, but not Dyn1, to be part of a biochemically isolated complex comprised of Homer and metabotropic glutamate receptors. Finally, although dominant-negative Dyn3 did not seem to inhibit receptor endocytosis, overexpression of a specific Dyn3 spliced variant in mature neurons caused a marked remodeling of dendritic spines. These data suggest that Dyn3 is a postsynaptic dynamin and, like its binding partner Homer, plays a significant role in dendritic spine morphogenesis and remodeling.
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“Thus, loss of certain cytoskeletal proteins appears to be a common mechanism in AD, PD, and ALS, whereas AD-specific modules are linked to a loss of a select group of microtubule and related proteins represented respectively by hubs MAP1B (E-M10) and DNM3 (E-M20) (Gray et al., 2003; Kawakami et al., 2003).”
From A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease (2017) · cites this paper as Gray et al., 2003
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Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,491
Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.
Damke, H., Baba, T., Warnock, D. E., & Schmid, S. L. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.4.915 · Cited by 1,203
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Homer: a protein that selectively binds metabotropic glutamate receptors
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Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic
van der Bliek, A. M., & Meyerowrtz, E. M. (1991) · Nature · doi:10.1038/351411a0 · Cited by 776
Dynamin-mediated Internalization of Caveolae
Henley, J. R., Krueger, E. W. A., Oswald, B. J., & McNiven, M. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.1.85 · Cited by 767
Self-citationMultiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis
Chen, M. S., Obar, R. A., Schroeder, C. C., Austin, T. W., Poodry, C. A., Wadsworth, S. C., & Vallee, R. B. (1991) · Nature · doi:10.1038/351583a0 · Cited by 558
Extraction of spots in biological images using multiscale products
Olivo‐Marín, J. (2002) · Pattern Recognition · doi:10.1016/s0031-3203(01)00127-3 · Cited by 540
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The dynamin superfamily: universal membrane tubulation and fission molecules?
Praefcke, G. J. K., & McMahon, H. T. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1313 · Cited by 1,370
Dynamin, a membrane-remodelling GTPase
Ferguson, S. M., & Camilli, P. V. D. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3266 · Cited by 1,027
The cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792
Seyfried, N. T., Dammer, E. B., Swarup, V., Nandakumar, D., Duong, D. M., Yin, L., Deng, Q., Nguyen, T., Hales, C. M., Wingo, T., et al. (2017) · Cell Systems · doi:10.1016/j.cels.2016.11.006 · Cited by 477
Metadata
- Authors
- Gray, N. W., Fourgeaud, L., Huang, B., Chen, J., Cao, H., Oswald, B. J., Hémar, A., & McNiven, M. A.
- Affiliations
- Mayo Clinic (US)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- McNiven, Mark A.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 13
- Issue
- 6
- Pages
- 510-515
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2086499290
- Cited by
- 143
- References
- 33
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 12 · 2012: 8
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3791 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t32ns007424-05)
- National Institute of Neurological Disorders and Stroke (NS07424)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- DNM3, postsynaptic density, metabotropic glutamate receptor 5, Homer, dendritic spines, spine morphogenesis, dynamin 1, alternative splicing, receptor internalization, synaptic localization
- MeSH terms
- Homer Scaffolding Proteins, Amino Acid Sequence, Animals, Carrier Proteins, Dendrites, Microscopy, Fluorescence, Molecular Sequence Data, Neuropeptides, Protein Binding, Synapses, Sequence Homology, Amino Acid, Presynaptic Terminals, Kainic Acid Receptors, Protein Transport, Dynamin I, Dynamin III, Rats
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