Casein kinase I transduces Wnt signals

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429 · see citing works

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., & Pease, L. R. (1989) · Gene · doi:10.1016/0378-1119(89)90358-2 · Cited by 7,354 · see citing works

Functional interaction of β-catenin with the transcription factor LEF-1

Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912 · see citing works

Wnt signaling: a common theme in animal development

Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567 · see citing works

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

Nusse, R., & VARMUS, H. E. (1982) · Cell · doi:10.1016/0092-8674(82)90409-3 · Cited by 1,864 · see citing works

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824 · see citing works

A new member of the frizzled family from Drosophila functions as a Wingless receptor

Bhanot, P., van den Brink, M. R. M., Samos, C. H., Hsieh, J.-C., Wang, Y., Macke, J. P., Andrew, D. J., Nathans, J., & Nusse, R. (1996) · Nature · doi:10.1038/382225a0 · Cited by 1,504 · see citing works

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

Chien, C., Bartel, P. L., Sternglanz, R., & Fields, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9578 · Cited by 1,494 · see citing works

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

Rubinfeld, B., Robbins, P. F., El‐Gamil, M., Albert, I., Porfiri, E., & Polakis, P. G. (1997) · Science · doi:10.1126/science.275.5307.1790 · Cited by 1,223 · see citing works

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.Preprint

Yost, C., Torres, M., Miller, J., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,167 · see citing works

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

Sasai, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90068-x · Cited by 1,122 · see citing works

A major developmental transition in early xenopus embryos: II. control of the onset of transcription

Newport, J., & Kirschner, M. (1982) · Cell · doi:10.1016/0092-8674(82)90273-2 · Cited by 1,055 · see citing works

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T. J., Perry, W. L., Lee, J. J., Tilghman, S. M., Gumbiner, B. M., & Costantini, F. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80324-4 · Cited by 907 · see citing works

The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε

Kloss, B., Price, J. L., Sáez, L., Blau, J., Rothenfluh, A., Wesley, C. S., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81225-8 · Cited by 682 · see citing works

Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos

Rocheleau, C. E., Downs, W. D., Lin, R., Wittmann, C., Bei, Y., Cha, Y.-H., Ali, M., Priess, J. R., & Mello, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80531-0 · Cited by 660 · see citing works

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

Smith, W. C., & Harland, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90070-f · Cited by 649 · see citing works

RNAi in C. elegans : Soaking in the Genome Sequence

Tabara, H., Grishok, A., & Mello, C. C. (1998) · Science · doi:10.1126/science.282.5388.430 · Cited by 647 · see citing works

Overexpression of cadherins and underexpression of ?-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

Heasman, J. (1994) · Cell · doi:10.1016/0092-8674(94)90069-8 · Cited by 643 · see citing works

WNTs modulate cell fate and behavior during vertebrate development

Moon, R. T. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01093-7 · Cited by 601 · see citing works

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

Thomsen, G. H., Woolf, T. M., Whitman, M., Sokol, S. Y., Vaughan, J. M., Vale, W., & Melton, D. A. (1990) · Cell · doi:10.1016/0092-8674(90)90445-k · Cited by 586 · see citing works

A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1

Songyang, Z., Lu, K. P., Kwon, Y. T., Tsai, L., Filhol, O., Cochet, C., Brickey, D. A., Soderling, T. R., Bartleson, C., Graves, D. J., et al. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6486 · Cited by 550 · see citing works

Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis

McMahon, A. P., & Moon, R. T. (1989) · Cell · doi:10.1016/0092-8674(89)90506-0 · Cited by 530 · see citing works

A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in XenopusPreprint

Brannon, M. K., Gomperts, M., Sumoy, L., Moon, R. T., & Kimelman, D. (1997) · Genes & Development · doi:10.1101/gad.11.18.2359 · Cited by 522 · see citing works

Wnt Signaling Polarizes an Early C. elegans Blastomere to Distinguish Endoderm from Mesoderm

Thorpe, C. J., Schlesinger, A., Carter, J. C., & Bowerman, B. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80530-9 · Cited by 514 · see citing works

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

He, X., Saint‐Jeannet, J., Woodgett, J. R., VARMUS, H. E., & Dawid, I. B. (1995) · Nature · doi:10.1038/374617a0 · Cited by 490 · see citing works

Advances in second messenger and phosphoprotein research

(1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90270-s · Cited by 482 · see citing works

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

Graff, J. M., Thies, R. S., Song, J. J., Celeste, A. J., & Melton, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90409-x · Cited by 451 · see citing works

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

Graff, J. M., Bansal, A., & Melton, D. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81249-0 · Cited by 424 · see citing works

The interface of sigma with core RNA polymerase is extensive, conserved, and functionally specializedPreprint

Sharp, M. M., Chan, C. L., Lu, C., Marr, M. T., Nechaev, S., Merritt, E., Severinov, K., Roberts, J. W., & Gross, C. A. (1999) · Genes & Development · doi:10.1101/gad.13.22.3015 · Cited by 418 · see citing works

Analysis of Dishevelled signalling pathways during Xenopus development

Sokol, S. Y. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00750-6 · Cited by 406 · see citing works

The mRNA encoding elongation factor 1-α (EF-1α) is a major transcript at the midblastula transition in Xenopus

Krieg, P. A., Varnum, S. M., Wormington, W. M., & Melton, D. A. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90300-x · Cited by 391 · see citing works

The dishevelled protein is modified by wingless signaling in Drosophila.Preprint

Yanagawa, S.-I., van Leeuwen, F. N., Wodarz, A., Klingensmith, J., & Nusse, R. (1995) · Genes & Development · doi:10.1101/gad.9.9.1087 · Cited by 388 · see citing works

Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.Preprint

Hoppler, S., Brown, J. D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.21.2805 · Cited by 346 · see citing works

GBP, an Inhibitor of GSK-3, Is Implicated in Xenopus Development and Oncogenesis

Yost, C., Farr, G. H., Pierce, S. B., Ferkey, D. M., Chen, M. M., & Kimelman, D. (1998) · Cell · doi:10.1016/s0092-8674(00)81208-8 · Cited by 328 · see citing works

Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1

Zhu, J., Shibasaki, F., Price, R., Guillemot, J.-C., Yano, T., Dötsch, V., Wagner, G., Ferrara, P., & McKeon, F. (1998) · Cell · doi:10.1016/s0092-8674(00)81445-2 · Cited by 307 · see citing works

RNAi and double-strand RNAPreprint

Sharp, P. A. (1999) · Genes & Development · doi:10.1101/gad.13.2.139 · Cited by 258 · see citing works

The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos

Bowerman, B. A., Draper, B. W., Mello, C. C., & Priess, J. R. (1993) · Cell · doi:10.1016/0092-8674(93)80046-h · Cited by 251 · see citing works

Casein kinase 2 associates with and phosphorylates Dishevelled

Willert, K., Brink, M., Wodarz, A., Varmus, H., & Nusse, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3089 · Cited by 249 · see citing works

LEF-1/TCF Proteins Mediate Wnt-Inducible Transcription from the Xenopus Nodal-Related 3 Promoter

McKendry, R., Hsu, S.-C., Harland, R. M., & Grosschedl, R. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8797 · Cited by 242 · see citing works

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

Pierce, S. B., & Kimelman, D. (1995) · Development · doi:10.1242/dev.121.3.755 · Cited by 230 · see citing works

Axis determination in eggs of Xenopus laevis: A critical period before first cleavage, identified by the common effects of cold, pressure and ultraviolet irradiation

Scharf, S. R., & Gerhart, J. C. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90255-5 · Cited by 228 · see citing works

The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm

Carnac, G., Kodjabachian, L., Gurdon, J. B., & Lemaire, P. (1996) · Development · doi:10.1242/dev.122.10.3055 · Cited by 208 · see citing works

HRR25, a Putative Protein Kinase from Budding Yeast: Association with Repair of Damaged DNA

Hoekstra, M. F., Liskay, R. M., Ou, A. C., DeMaggio, A. J., Burbee, D. G., & Heffron, F. (1991) · Science · doi:10.1126/science.1887218 · Cited by 181 · see citing works

Isolation and Characterization of Human Casein Kinase I∊ (CKI), a Novel Member of the CKI Gene Family

Gietzen, K. F., Cegielska, A., Getman, M. E., Landes, G. M., & Virshup, D. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.25.14875 · Cited by 167 · see citing works

A Newly Synthesized Selective Casein Kinase I Inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and Affinity Purification of Casein Kinase I from Bovine Testis

Chijiwa, T., Hagiwara, M., & Hidaka, H. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83679-1 · Cited by 164 · see citing works

Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis

Deardorff, M. A., Tan, C. L., Conrad, L. J., & Klein, P. S. (1998) · Development · doi:10.1242/dev.125.14.2687 · Cited by 160 · see citing works

Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist

Xu, Q., D'Amore, P. A., & Sokol, S. Y. (1998) · Development · doi:10.1242/dev.125.23.4767 · Cited by 114 · see citing works

The budding yeast HRR25 gene product is a casein kinase I isoform.

DeMaggio, A. J., Lindberg, R. A., Hunter, T., & Hoekstra, M. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.7008 · Cited by 82 · see citing works

Cell interactions involved in development of the bilaterally symmetrical intestinal valve cells during embryogenesis in Caenorhabditis elegans

Bowerman, B. A., Tax, F. E., Thomas, J. H., & Priess, J. R. (1992) · Development · doi:10.1242/dev.116.4.1113 · Cited by 60 · see citing works

Spemann organizer activity of Smad10

LeSueur, J. A., & Graff, J. M. (1999) · Development · doi:10.1242/dev.126.1.137 · Cited by 49 · see citing works

Wnt signaling and cancer

Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183 · see citing works

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

Liu, C., Li, Y., Semënov, M. V., Han, C., Baeg, G., Tan, Y., Zhang, Z., Lin, X., & He, X. (2002) · Cell · doi:10.1016/s0092-8674(02)00685-2 · Cited by 2,074 · see citing works

Wnt signalling and its impact on development and cancer

Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595 · see citing works

Wnt signal transduction pathways

Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528 · see citing works

Caught up in a Wnt storm: Wnt signaling in cancer

Giles, R. H., van Es, J. H., & Clevers, H. (2003) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(03)00005-2 · Cited by 1,482 · see citing works

GSK3 takes centre stage more than 20 years after its discovery

FRAME, S., & COHEN, P. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590001 · Cited by 1,433 · see citing works

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

Peifer, M., & Polakis, P. (2000) · Science · doi:10.1126/science.287.5458.1606 · Cited by 1,253 · see citing works

Osteocytes, mechanosensing and Wnt signaling

Bonewald, L. F., & Johnson, M. L. (2008) · Bone · doi:10.1016/j.bone.2007.12.224 · Cited by 1,076 · see citing works

The -Catenin Destruction Complex

Stamos, J. L., & Weis, W. I. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007898 · Cited by 1,062 · see citing works

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

Zeng, X., Tamai, K., Doble, B. W., Li, S., Huang, H., Habas, R., Okamura, H., Woodgett, J. R., & He, X. (2005) · Nature · doi:10.1038/nature04185 · Cited by 849 · see citing works

Dishevelled: The hub of Wnt signaling

Gao, C., & Chen, Y. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.021 · Cited by 751 · see citing works

Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathwayPreprint

Amit, S., Hatzubai, A., Birman, Y., Andersen, J., Ben-Shushan, E., Mann, M., Ben‐Neriah, Y., & Alkalay, I. (2002) · Genes & Development · doi:10.1101/gad.230302 · Cited by 754 · see citing works

Frizzled and LRP5/6 Receptors for Wnt/ -Catenin SignalingPreprint

MacDonald, B. T., & He, X. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007880 · Cited by 610 · see citing works

The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., & Stöter, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.011 · Cited by 601 · see citing works

Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

Davidson, G. R., Wu, W., Shen, J., Bilić, J., Fenger, U., Stannek, P., Glinka, A., & Niehrs, C. (2005) · Nature · doi:10.1038/nature04170 · Cited by 581 · see citing works

New aspects of Wnt signaling pathways in higher vertebrates

Huelsken, J., & Birchmeier, W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00231-8 · Cited by 552 · see citing works

Ca2+/Calmodulin-dependent Protein Kinase II Is Stimulated by Wnt and Frizzled Homologs and Promotes Ventral Cell Fates in Xenopus

Kühl, M., Sheldahl, L. C., Malbon, C. C., & Moon, R. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12701 · Cited by 517 · see citing works

A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock

Martinek, S., Inonog, S., Manoukian, A. S., & Young, M. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00383-x · Cited by 513 · see citing works

The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509 · see citing works

Wnt signaling: complexity at the surface

Cadigan, K. M., & Liu, Y. I. (2006) · Journal of Cell Science · doi:10.1242/jcs.02826 · Cited by 486 · see citing works

Dual roles of Wnt signaling during chondrogenesis in the chicken limb

Hartmann, C., & Tabin, C. J. (2000) · Development · doi:10.1242/dev.127.14.3141 · Cited by 472 · see citing works

Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling

Ding, V. W., Chen, R., & McCormick, F. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005342200 · Cited by 428 · see citing works

In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction

Osakada, F., Jin, Z.-B., Hirami, Y., Ikeda, H., Danjyo, T., Watanabe, K., Sasai, Y., & Takahashi, M. (2009) · Journal of Cell Science · doi:10.1242/jcs.050393 · Cited by 439 · see citing works

WNT Signaling in Cardiac and Vascular Disease

Foulquier, S., Daskalopoulos, E. P., Lluri, G., Hermans, K. C. M., Deb, A., & Blankesteijn, W. M. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.013896 · Cited by 344 · see citing works

Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4

Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L. A., Miller, W. E., Caron, M. G., Barak, L. S., Nusse, R., & Lefkowitz, R. J. (2003) · Science · doi:10.1126/science.1082808 · Cited by 334 · see citing works

Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction

Wharton, K. A. (2003) · Developmental Biology · doi:10.1006/dbio.2002.0869 · Cited by 315 · see citing works

Proteolysis of the Hedgehog Signaling Effector Cubitus interruptus Requires Phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1

Price, M. A., & Kalderon, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00664-5 · Cited by 381 · see citing works

Wnt/β-catenin signalling: from plasma membrane to nucleus

Kim, W., Kim, M., & Jho, E. (2013) · Biochemical Journal · doi:10.1042/bj20121284 · Cited by 310 · see citing works

Wnt signaling and the activation of myogenesis in mammals

Cossu, G., & Borello, U. (1999) · The EMBO Journal · doi:10.1093/emboj/18.24.6867 · Cited by 312 · see citing works

Mechanism of Phosphorylation-Dependent Binding of APC to β-Catenin and Its Role in β-Catenin Degradation

Ha, N., Tonozuka, T., Stamos, J. L., Choi, H., & Weis, W. I. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.010 · Cited by 304 · see citing works

Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ

Vielhaber, E. L., Eide, E. J., Rivers, A. M., Gao, Z.-H., & Virshup, D. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4888-4899.2000 · Cited by 308 · see citing works

The Circadian Regulatory Proteins BMAL1 and Cryptochromes Are Substrates of Casein Kinase Iε

Eide, E. J., Vielhaber, E. L., Hinz, W. A., & Virshup, D. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111466200 · Cited by 301 · see citing works

Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis

Rothbächer, U., Laurent, M. N., Deardorff, M. A., Klein, P. S., Cho, K. W. Y., & Fraser, S. E. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.1010 · Cited by 299 · see citing works

C. elegans

McKay, R. M., McKay, J. P., Avery, L., & Graff, J. M. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00411-2 · Cited by 288 · see citing works

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis

Knippschild, U., Krüger, M., Richter, J., Xu, P., García-Reyes, B., Peifer, C., Halekotte, J., Bakulev, V. A., & Bischof, J. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00096 · Cited by 276 · see citing works

Hedgehog signaling plays a conserved role in inhibiting fat formation

Suh, J. M., Gao, X., McKay, J., McKay, R. M., Salo, Z., & Graff, J. M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.012 · Cited by 271 · see citing works

Biochemical interactions in the wnt pathway

Seidensticker, M. J., & Behrens, J. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00158-5 · Cited by 259 · see citing works

The Frizzled family of unconventional G-protein-coupled receptors

Schulte, G., & Bryja, V. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.09.001 · Cited by 253 · see citing works

CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signalingPreprint

Price, M. A. (2006) · Genes & Development · doi:10.1101/gad.1394306 · Cited by 257 · see citing works

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

Sun, T., Lu, B., Feng, J., Reinhard, C., Jan, Y. N., Fantl, W. J., & Williams, L. T. (2001) · Nature Cell Biology · doi:10.1038/35083016 · Cited by 255 · see citing works

The links between axin and carcinogenesis

Salahshor, S., & Woodgett, J. R. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2003.009506 · Cited by 250 · see citing works

Dapper, a Dishevelled-Associated Antagonist of β-Catenin and JNK Signaling, Is Required for Notochord Formation

Cheyette, B. N. R., Waxman, J. S., Miller, J. R., Takemaru, K., Sheldahl, L. C., Khlebtsova, N., Fox, E. P., Earnest, T. N., & Moon, R. T. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00140-5 · Cited by 249 · see citing works

Estrogen Receptor-Dependent Genomic Responses in the Uterus Mirror the Biphasic Physiological Response to Estrogen

Hewitt, S. C., Deroo, B. J., Hansen, K., Collins, J. B., Grissom, S. F., Afshari, C. A., & Korach, K. S. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0146 · Cited by 247 · see citing works

The subcellular destinations of apc proteins

Bienz, M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm806 · Cited by 243 · see citing works

Ror‐family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases

Minami, Y., Oishi, I., Endo, M., & Nishita, M. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21991 · Cited by 240 · see citing works

Wnt / β-Catenin Signaling Pathway as Novel Cancer Drug Targets

Luu, H. H., Zhang, R., Haydon, R. C., Rayburn, E. R., Kang, Q., Si, W., Park, J. K., Wang, H., Peng, Y., Jiang, W., et al. (2004) · Current Cancer Drug Targets · doi:10.2174/1568009043332709 · Cited by 232 · see citing works

Dynamic recruitment of axin by Dishevelled protein assemblies

Schwarz, T., Metcalfe, C., & Bienz, M. (2007) · Journal of Cell Science · doi:10.1242/jcs.002956 · Cited by 225 · see citing works

Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex

Gao, Z.-H., Seeling, J. M., Hill, V., Yochum, A., & Virshup, D. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032468199 · Cited by 225 · see citing works

Rice early flowering1, a CKI, phosphorylates DELLA protein SLR1 to negatively regulate gibberellin signalling

Dai, C., & Xue, H. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.75 · Cited by 223 · see citing works

Dishevelled: A masterful conductor of complex Wnt signals

Sharma, M., Castro‐Piedras, I., Simmons, G. E., Jr., & Pruitt, K. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.03.004 · Cited by 216 · see citing works

Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling

Itoh, K., Brott, B. K., Bae, G.-U., Ratcliffe, M. J., & Sokol, S. Y. (2005) · Journal of Biology · doi:10.1186/jbiol20 · Cited by 221 · see citing works

Wnt signaling

Eisenmann, D. M. (2005) · WormBook · doi:10.1895/wormbook.1.7.1 · Cited by 220 · see citing works

GSK3, a master switch regulating cell-fate specification and tumorigenesis

Kim, L., & Kimmel, A. R. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00120-9 · Cited by 219 · see citing works

The way Wnt works: Components and mechanism

Saito‐Diaz, K., Chen, T. W., Wang, X., Thorne, C. A., Wallace, H. A., Page, A. W., & Lee, E. N. (2012) · Growth Factors · doi:10.3109/08977194.2012.752737 · Cited by 216 · see citing works

RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt–β-Catenin Signaling

Cruciat, C., Dolde, C. E., de Groot, R. E. A., Ohkawara, B., Reinhard, C., Korswagen, H. C., & Niehrs, C. (2013) · Science · doi:10.1126/science.1231499 · Cited by 207 · see citing works

Wnt signalling in kidney diseases: dual roles in renal injury and repair

Kawakami, T., Ren, S., & Duffield, J. S. (2012) · The Journal of Pathology · doi:10.1002/path.4121 · Cited by 205 · see citing works

Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase

Inuzuka, H., Tseng, A., Gao, D., Zhai, B., Zhang, Q. H., Shaik, S., Wan, L., Cambronne, X. A., Mock, C. S., Yin, H., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.06.015 · Cited by 205 · see citing works

Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila

Yanagawa, S.-I., Matsuda, Y., Lee, J.-S., Matsubayashi, H., Sese, S., Kadowaki, T., & Ishimoto, A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1733 · Cited by 202 · see citing works

Casein Kinase 1 Regulates Connexin-43 Gap Junction Assembly

Cooper, C. D., & Lampe, P. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209427200 · Cited by 200 · see citing works

NONCANONICAL WNT SIGNALING AND NEURAL POLARITY

Montcouquiol, M., Crenshaw, E. B., & Kelley, M. W. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112933 · Cited by 191 · see citing works

Endogenous Protein Kinase CK2 Participates in Wnt Signaling in Mammary Epithelial Cells

Song, D. H., Sussman, D. J., & Seldin, D. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909107199 · Cited by 192 · see citing works

Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS

Schneider, R. K., Ademà, V., Heckl, D., Järås, M., Mallo, M., Lord, A. M., Chu, L. P., McConkey, M. E., Kramann, R., Mullally, A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.08.001 · Cited by 188 · see citing works

The DIX domain targets dishevelled to actin stress fibres and vesicular membranes

Capelluto, D. G. S., Kutateladze, T. G., Habas, R., Finkielstein, C. V., He, X., & Overduin, M. (2002) · Nature · doi:10.1038/nature01056 · Cited by 190 · see citing works

The ankyrin repeat protein Diversin recruits Casein kinase Iε to the β-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signalingPreprint

Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kühl, M., Schaeffer, H.-J., Huelsken, J., Behrens, J., Hammerschmidt, M., & Birchmeier, W. (2002) · Genes & Development · doi:10.1101/gad.230402 · Cited by 189 · see citing works

The Wnt Antagonist Frzb-1 Regulates Chondrocyte Maturation and Long Bone Development during Limb Skeletogenesis

Enomoto‐Iwamoto, M., Kitagaki, J., Koyama, E., Tamamura, Y., Wu, C., Kanatani, N., Koike, T., Okada, H., Komori, T., Yoneda, T., et al. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0802 · Cited by 188 · see citing works

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

Bryja, V., Schulte, G., Rawal, N., Grahn, A., & Arenas, E. (2007) · Journal of Cell Science · doi:10.1242/jcs.03368 · Cited by 186 · see citing works

Wnt signaling is required at distinct stages of development for the induction of the posterior forebrain

Braun, M. M., Etheridge, A., Bernard, A., Robertson, C. P., & Roelink, H. (2003) · Development · doi:10.1242/dev.00685 · Cited by 182 · see citing works

Wnt Proteins Induce Dishevelled Phosphorylation via an LRP5/6- Independent Mechanism, Irrespective of Their Ability To Stabilize β-Catenin

González‐Sancho, J. M., Brennan, K. R., Castelo‐Soccio, L. A., & Brown, A. M. C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4757-4768.2004 · Cited by 182 · see citing works

The WNT signaling pathway from ligand secretion to gene transcription: Molecular mechanisms and pharmacological targets

Baarsma, H. A., Königshoff, M., & Gosens, R. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.002 · Cited by 175 · see citing works

Protein Kinases and Phosphatases in the Drosophila Genome

Morrison, D. K., Murakami, M. S., & Cleghon, V. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.2.f57 · Cited by 175 · see citing works

Casein kinase 1α governs antigen-receptor-induced NF-κB activation and human lymphoma cell survival

Bidère, N., Ngo, V. N., Lee, J., Collins, C. T., Zheng, L., Wan, F., Davis, R. E., Lenz, G., Anderson, D. E., Arnoult, D., et al. (2008) · Nature · doi:10.1038/nature07613 · Cited by 174 · see citing works

The Wnt Signaling Pathway in Bipolar Disorder

Gould, T. D., & Manji, H. K. (2002) · The Neuroscientist · doi:10.1177/107385802237176 · Cited by 173 · see citing works

An opposite role for tau in circadian rhythms revealed by mathematical modeling

Gallego, M., Eide, E. J., Woolf, M. F., Virshup, D. M., & Forger, D. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604511103 · Cited by 176 · see citing works

Essential roles of CKIδ and CKIε in the mammalian circadian clock

Lee, H.-M., Chen, R., Lee, Y., Yoo, S. H., & Lee, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906651106 · Cited by 172 · see citing works

CK2 Phosphorylation of the Armadillo Repeat Region of β-Catenin Potentiates Wnt Signaling

Song, D. H., Dominguez, I. M., Mizuno, J., Kaut, M., Mohr, S. C., & Seldin, D. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212260200 · Cited by 167 · see citing works

Plasmodesmal-Associated Protein Kinase in Tobacco and Arabidopsis Recognizes a Subset of Non-Cell-Autonomous Proteins

Lee, J., Taoka, K., Yoo, B.-C., Ben‐Nissan, G., Kim, D., & Lucas, W. J. (2005) · The Plant Cell · doi:10.1105/tpc.105.034330 · Cited by 167 · see citing works

Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd

Yan, D. M., Wallingford, J. B., Sun, T., Nelson, A. M., Sakanaka, C., Reinhard, C., Harland, R. M., Fantl, W. J., & Williams, L. T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071041898 · Cited by 167 · see citing works

Regulation of Wnt/β‐catenin signaling by protein kinases

Verheyen, E. M., & Gottardi, C. J. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22019 · Cited by 161 · see citing works

naked cuticle targets dishevelled to antagonize Wnt signal transductionPreprint

Rousset, R., Mack, J. A., Wharton, K. A., Axelrod, J. D., Cadigan, K. M., Fish, M., Nusse, R., & Scott, M. P. (2001) · Genes & Development · doi:10.1101/gad.869201 · Cited by 160 · see citing works

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

Pérez, D. I., Gil, C., & Martı́nez, A. (2010) · Medicinal Research Reviews · doi:10.1002/med.20207 · Cited by 155 · see citing works

Casein Kinase 1: A Wnt'er of Disconnect

Polakis, P. G. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00969-7 · Cited by 154 · see citing works

Axin: A Master Scaffold for Multiple Signaling Pathways

Luo, W., & Lin, S. (2004) · Neurosignals · doi:10.1159/000076563 · Cited by 154 · see citing works

Crystal Structure of a Conformation-selective Casein Kinase-1 Inhibitor

Mashhoon, N., DeMaggio, A. J., Tereshko, V. A., Bergmeier, S. C., Egli, M., Hoekstra, M. F., & Kuret, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001713200 · Cited by 149 · see citing works

Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases

Schwab, C., DeMaggio, A. J., Ghoshal, N., Binder, L. I., Kuret, J., & McGeer, P. L. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00110-x · Cited by 148 · see citing works

Multiple Wnt Signaling Pathways Converge to Orient the Mitotic Spindle in Early C. elegans Embryos

Walston, T., Tuskey, C., Edgar, L. G., Hawkins, N., Ellis, G. C., Bowerman, B. A., Wood, W. B., & Hardin, J. D. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.10.008 · Cited by 144 · see citing works

Discovering novel chemotherapeutic drugs for the third millennium

Garrett, M. D., & Workman, P. (1999) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00280-4 · Cited by 141 · see citing works

Wnt signaling promotes proliferation and stemness regulation of spermatogonial stem/progenitor cells

Golestaneh, N., Beauchamp, E. M., Fallen, S., Kokkinaki, M., Üren, A., & Dym, M. (2009) · Reproduction · doi:10.1530/rep-08-0510 · Cited by 142 · see citing works

Role of glycogen synthase kinase-3 in cancer: Regulation by Wnts and other signaling pathways

Manoukian, A. S., & Woodgett, J. R. (2002) · Advances in cancer research · doi:10.1016/s0065-230x(02)84007-6 · Cited by 142 · see citing works

Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled

Cong, F., Schweizer, L., & VARMUS, H. E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.2000-2011.2004 · Cited by 142 · see citing works

Similarities between the Hedgehog and Wnt signaling pathways

Kalderon, D. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02388-7 · Cited by 141 · see citing works

Physiological regulation of β-catenin stability by Tcf3 and CK1ϵ

Lee, E. N., Salic, A. N., & Kirschner, M. W. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200102074 · Cited by 141 · see citing works

The Many Faces of the Tumor Suppressor Gene APC

van Es, J. H., Giles, R. H., & Clevers, H. C. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5142 · Cited by 138 · see citing works

Phosphorylation by Double-Time/CKIε and CKIα Targets Cubitus Interruptus for Slimb/β-TRCP-Mediated Proteolytic Processing

Jia, J., Zhang, L., Zhang, Q. H., Tong, C., Wang, B., Hou, F., Amanai, K., & Jiang, J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.10.006 · Cited by 138 · see citing works

Roles of OsCKI1, a rice casein kinase I, in root development and plant hormone sensitivity

Liu, W., Xu, Z. H., Luo, D., & Xue, H. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01866.x · Cited by 137 · see citing works

β-Arrestin is a necessary component of Wnt/β-catenin signaling in vitro and in vivo

Bryja, V., Gradl, D., Schambony, A., Arenas, E., & Schulte, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611356104 · Cited by 136 · see citing works

Canonical and non‐canonical Wnt signaling pathways in Caenorhabditis elegans : variations on a common signaling theme

Korswagen, H. C. (2002) · BioEssays · doi:10.1002/bies.10145 · Cited by 136 · see citing works

Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3

Lee, Y.-N., Gao, Y., & Wang, H. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.11.005 · Cited by 133 · see citing works

Regulation of the Wnt signaling pathway by disabled‐2 (Dab2)

Hocevar, B. A., Mou, F., Rennolds, J., Morris, S. M., Cooper, J. A., & Howe, P. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg286 · Cited by 134 · see citing works

PECAM‐1 shedding during apoptosis generates a membrane‐anchored truncated molecule with unique signaling characteristics

Ilan, N., Mohsenin, A., Cheung, L., & Madri, J. A. (2001) · The FASEB Journal · doi:10.1096/fj.00-0372com · Cited by 133 · see citing works

FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway

Asad, M., Wong, M. K., Tan, T. Z., Choolani, M. A., Low, J. J. H., Mori, S., Virshup, D. M., Thiery, J. P., & Huang, R. Y. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.302 · Cited by 131 · see citing works

Wnt cascade gains dishevelled kinase

(1999) · Science Signaling · doi:10.1126/scisignal.11999tw3

The Casein Kinase I Family in Wnt Signaling

McKay, R. M., Peters, J. M., & Graff, J. M. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0308 · Cited by 111 · see citing works

The Casein Kinase I Family: Roles in Morphogenesis

McKay, R. M., Peters, J. M., & Graff, J. M. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0307 · Cited by 50 · see citing works

Casein kinase Iɛ in the Wnt pathway: Regulation of β-catenin function

Sakanaka, C., Leong, P. C., Xu, L., Harrison, S. D., & Williams, L. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12548 · Cited by 213 · see citing works

Regulation of Casein Kinase Iϵ Activity by Wnt Signaling

Swiatek, W., Tsai, I.-C., Klimowski, L., Pepler, A., Barnette, J. E., Yost, H. J., & Virshup, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m304682200 · Cited by 106 · see citing works