Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis
Open accessAbstract
Dishevelled (Dsh) induces a secondary axis and can translocate to the membrane when activated by Frizzleds; however, dominant-negative approaches have not supported a role for Dsh in primary axis formation. We demonstrate that the Dsh protein is post-translationally modified at the dorsal side of the embryo: timing and position of this regulation suggests a role of Dsh in dorsal-ventral patterning in Xenopus. To create functional links between these properties of Dsh we analyzed the influence of endogenous Frizzleds and the Dsh domain dependency for these characteristics. Xenopus Frizzleds phosphorylate and translocate Xdsh to the membrane irrespective of their differential ectopic axes inducing abilities, showing that translocation is insufficient for axis induction. Dsh deletion analysis revealed that axis inducing abilities did not segregate with Xdsh membrane association. The DIX region and a short stretch at the N-terminus of the DEP domain are necessary for axis induction while the DEP region is required for Dsh membrane association and its phosphorylation. In addition, Dsh forms homomeric complexes in embryos suggesting that multimerization is important for its proper function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The DEP domain is required for membrane translocation of Dsh.
“The DEP domain is also required for membrane translocation of Dsh.117”
From Wnt signal transduction pathways (2008) · cites this paper as [117]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567 · see citing works
A new member of the frizzled family from Drosophila functions as a Wingless receptor
Bhanot, P., van den Brink, M. R. M., Samos, C. H., Hsieh, J.-C., Wang, Y., Macke, J. P., Andrew, D. J., Nathans, J., & Nusse, R. (1996) · Nature · doi:10.1038/382225a0 · Cited by 1,504 · see citing works
Kennerdell, J. R., & Carthew, R. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81725-0 · Cited by 1,133 · see citing works
Doyle, D., Lee, A., Lewis, J. H., Kim, E., Sheng, M., & MacKinnon, R. (1996) · Cell · doi:10.1016/s0092-8674(00)81307-0 · Cited by 1,126 · see citing works
Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T. J., Perry, W. L., Lee, J. J., Tilghman, S. M., Gumbiner, B. M., & Costantini, F. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80324-4 · Cited by 907 · see citing works
Boutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81226-x · Cited by 801 · see citing works
Slusarski, D. C., Corces, V. G., & Moon, R. T. (1997) · Nature · doi:10.1038/37138 · Cited by 680 · see citing works
Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T., & Perrimon, N. (1998) · Genes & Development · doi:10.1101/gad.12.16.2610 · Cited by 659 · see citing works
Signal transduction through beta-catenin and specification of cell fate during embryogenesis.
Miller, J. R., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.20.2527 · Cited by 656 · see citing works
The oncogenic activation of β-catenin
Polakis, P. G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80003-3 · Cited by 651 · see citing works
Koelle, M. R., & Horvitz, H. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80998-8 · Cited by 573 · see citing works
The role of RhoA in tissue polarity and Frizzled signalling
Strutt, D. I., Weber, U., & Mlodzik, M. (1997) · Nature · doi:10.1038/387292a0 · Cited by 560 · see citing works
Brannon, M. K., Gomperts, M., Sumoy, L., Moon, R. T., & Kimelman, D. (1997) · Genes & Development · doi:10.1101/gad.11.18.2359 · Cited by 522 · see citing works
β-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos
Schneider, S., Steinbeißer, H., Warga, R. M., & Hausen, P. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(96)00546-1 · Cited by 515 · see citing works
A frizzled homolog functions in a vertebrate Wnt signaling pathway
Yang-Snyder, J., Miller, J. R., Brown, J. D., Lai, C.-J., & Moon, R. T. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70716-1 · Cited by 469 · see citing works
Casein kinase I transduces Wnt signals
Peters, J. M., McKay, R. M., McKay, J. P., & Graff, J. M. (1999) · Nature · doi:10.1038/43830 · Cited by 447 · see citing works
Interaction Between Wingless and Notch Signaling Pathways Mediated by Dishevelled
Axelrod, J. D., Matsuno, K., Artavanis‐Tsakonas, S., & Perrimon, N. (1996) · Science · doi:10.1126/science.271.5257.1826 · Cited by 418 · see citing works
PDZ Domains: Targeting signalling molecules to sub‐membranous sites
Ponting, C. P., Phillips, C., Davies, K. E., & Blake, D. J. (1997) · BioEssays · doi:10.1002/bies.950190606 · Cited by 415 · see citing works
Larabell, C. A., Torres, M. A., Rowning, B. A., Yost, C., Miller, J. R., Wu, M., Kimelman, D., & Moon, R. T. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.5.1123 · Cited by 407 · see citing works
Analysis of Dishevelled signalling pathways during Xenopus development
Sokol, S. Y. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00750-6 · Cited by 406 · see citing works
Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt‐mediated regulation of LEF‐1
Li, L., Yuan, H., Weaver, C. D., Mao, J., Farr, G. H., Sussman, D. J., Jonkers, J., Kimelman, D., & Wu, D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.15.4233 · Cited by 403 · see citing works
Kishida, S., Yamamoto, H., Hino, S.-I., Ikeda, S., Kishida, M., & Kikuchi, A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4414 · Cited by 400 · see citing works
The dishevelled protein is modified by wingless signaling in Drosophila.Preprint
Yanagawa, S.-I., van Leeuwen, F. N., Wodarz, A., Klingensmith, J., & Nusse, R. (1995) · Genes & Development · doi:10.1101/gad.9.9.1087 · Cited by 388 · see citing works
Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.Preprint
Hawley, S. H. B., Wünnenberg-Stapleton, K., Hashimoto, C., Laurent, M. N., Watabe, T., Blumberg, B., & Cho, K. W. (1995) · Genes & Development · doi:10.1101/gad.9.23.2923 · Cited by 368 · see citing works
Self-citationdishevelled is required during wingless signaling to establish both cell polarity and cell identity
Theisen, H., Purcell, J. M., Bennett, M. K., Kansagara, D., Syed, A., & Marsh, J. (1994) · Development · doi:10.1242/dev.120.2.347 · Cited by 339 · see citing works
Crystal structure of a PDZ domain
Morais-Cabral, J. H., Petosa, C., Sutcliffe, M. J., Raza, S., Byron, O., Poy, F., Marfatia, S. M., Chishti, A. H., & Liddington, R. (1996) · Nature · doi:10.1038/382649a0 · Cited by 321 · see citing works
Moon, R. T., & Kimelman, D. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199807)20:7 · Cited by 317 · see citing works
Blitz, I. L., & Cho, W. Y. (1995) · Development · doi:10.1242/dev.121.4.993 · Cited by 314 · see citing works
Dishevelled Proteins Lead to Two Signaling Pathways
Li, L., Yuan, H., Xie, W., Mao, J., Caruso, A. M., McMahon, A., Sussman, D. J., & Wu, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.129 · Cited by 290 · see citing works
Fagotto, F., Jho, E., Zeng, L., Kurth, T., Joos, T., Kaufmann, C. M., & Costantini, F. D. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.4.741 · Cited by 269 · see citing works
Miller, J. R., Rowning, B. A., Larabell, C. A., Yang-Snyder, J., Bates, R. L., & Moon, R. T. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.2.427 · Cited by 254 · see citing works
Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye
Cooper, M. T. D., & Bray, S. J. (1999) · Nature · doi:10.1038/17395 · Cited by 249 · see citing works
Casein kinase 2 associates with and phosphorylates Dishevelled
Willert, K., Brink, M., Wodarz, A., Varmus, H., & Nusse, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3089 · Cited by 249 · see citing works
Interaction of Axin and Dvl‐2 proteins regulates Dvl‐2‐stimulated TCF‐dependent transcription
Smalley, M. J., Sara, E., Paterson, H., Naylor, S., Cook, D., Jayatilake, H., Fryer, L. G. D., Hutchinson, L., Fry, M., & Dale, T. C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.10.2823 · Cited by 247 · see citing works
Origin of PDZ (DHR, GLGF) domains
Kennedy, M. B. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89074-x · Cited by 233 · see citing works
Patterning the Xenopus blastula
Heasman, J. (1997) · Development · doi:10.1242/dev.124.21.4179 · Cited by 232 · see citing works
Gho, M., & Schweisguth, F. (1998) · Nature · doi:10.1038/30265 · Cited by 230 · see citing works
Fanto, M., & Mlodzik, M. (1999) · Nature · doi:10.1038/17389 · Cited by 225 · see citing works
Watabe, T., Kim, S., Candia, A. F., Rothbächer, U., Hashimoto, C., Inoue, K., & Cho, K. W. (1995) · Genes & Development · doi:10.1101/gad.9.24.3038 · Cited by 224 · see citing works
Self-citationLaurent, M. N., Blitz, I. L., Hashimoto, C., Rothbächer, U., & Cho, K. W. Y. (1997) · Development · doi:10.1242/dev.124.23.4905 · Cited by 219 · see citing works
Self-citationCasein kinase Iɛ in the Wnt pathway: Regulation of β-catenin function
Sakanaka, C., Leong, P. C., Xu, L., Harrison, S. D., & Williams, L. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12548 · Cited by 213 · see citing works
Ruel, L., Bourouis, M., Heitzler, P., Pantesco, V., & Simpson, P. (1993) · Nature · doi:10.1038/362557a0 · Cited by 200 · see citing works
Negative Regulation of Wingless Signaling by D-Axin, a Drosophila Homolog of Axin
Hamada, F., Tomoyasu, Y., Takatsu, Y., Nakamura, M., Nagai, S.-I., Suzuki, A., Fujita, F., Shibuyà, H., Toyoshima, K., Ueno, N., et al. (1999) · Science · doi:10.1126/science.283.5408.1739 · Cited by 197 · see citing works
Sokol, S. Y., Klingensmith, J., Perrimon, N., & Itoh, K. (1995) · Development · doi:10.1242/dev.121.6.1637 · Cited by 189 · see citing works
Jen, Y., Manova, K., & Benezra, R. (1996) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199611)207:3 · Cited by 184 · see citing works
Sussman, D. J., Klingensmith, J., Salinas, P. C., Adams, P. S., Nusse, R., & Perrimon, N. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1297 · Cited by 183 · see citing works
Notch is required for wingless signaling in the epidermis of Drosophila
Couso, J. P. (1994) · Cell · doi:10.1016/0092-8674(94)90195-3 · Cited by 179 · see citing works
Adler, P. N., Krasnow, R. E., & Liu, J. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00413-1 · Cited by 164 · see citing works
Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis
Deardorff, M. A., Tan, C. L., Conrad, L. J., & Klein, P. S. (1998) · Development · doi:10.1242/dev.125.14.2687 · Cited by 160 · see citing works
Self-citationRowning, B. A., Wells, J. N., Wu, M., Gerhart, J. C., Moon, R. T., & Larabell, C. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1224 · Cited by 157 · see citing works
Pleckstrin's repeat performance: a novel domain in G-protein signaling?
Ponting, C. P., & Peer Bork, B. (1996) · PubMed · Cited by 152 · see citing works
Characterization of Mouse Dishevelled (Dvl) Proteins in Wnt/Wingless Signaling Pathway
Lee, J.-S., Ishimoto, A., & Yanagawa, S.-I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21464 · Cited by 149 · see citing works
Moriguchi, T., Kawachi, K., Kamakura, S., Masuyama, N., Yamanaka, H., Matsumoto, K., Kikuchi, A., & Nishida, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30957 · Cited by 149 · see citing works
Pleckstrin's repeat performance: a novel domain in G-protein signaling?
Ponting, C. P., & Peer Bork, B. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)30027-3 · Cited by 120 · see citing works
Wingless signaling in the Drosophila embryo: zygotic requirements and the role of the frizzled genes
Müller, H. ‐. J., Samanta, R., & Wieschaus, E. F. (1999) · Development · doi:10.1242/dev.126.3.577 · Cited by 118 · see citing works
Bhat, K. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81726-2 · Cited by 110 · see citing works
Klingensmith, J., Yang, Y., Axelrod, J. D., Beier, D. R., Perrimon, N., & Sussman, D. J. (1996) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00549-7 · Cited by 110 · see citing works
Wittbrodt, J., & Rosa, F. (1994) · Genes & Development · doi:10.1101/gad.8.12.1448 · Cited by 109 · see citing works
Sokol, S. Y., Klingensmith, J., Perrrimon, N., & ltoh, K. (1995) · Development · doi:10.1242/dev.121.10.3487 · Cited by 86 · see citing works
Human Dishevelled Genes Constitute a DHR-Containing Multigene Family
Semënov, M. V., & Snyder, M. P. (1997) · Genomics · doi:10.1006/geno.1997.4713 · Cited by 81 · see citing works
Heslip, T. R., Theisen, H., Walker, H. A., & Marsh, J. L. (1997) · Development · doi:10.1242/dev.124.5.1069 · Cited by 75 · see citing works
Expression of Xfz3, a Xenopus frizzled family member, is restricted to the early nervous system
Shi, D., Goisset, C., & Boucaut, J. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00166-4 · Cited by 66 · see citing works
Rothbächer, U., Laurent, M. N., Blitz, I. L., Watabe, T., Marsh, J. L., & Cho, K. W. Y. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1249 · Cited by 62 · see citing works
Self-citationA role for Xenopus Frizzled 8 in dorsal development
Itoh, K., Jacob, J., & Sokol, S. Y. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00076-8 · Cited by 49 · see citing works
Evidence for a frizzled-mediated wnt pathway required for zebrafish dorsal mesoderm formation
Nasevicius, A., Hyatt, T. M., Kim, H., Guttman, J., Walsh, E., Sumanas, S., Wang, Y., & Ekker, S. C. (1998) · Development · doi:10.1242/dev.125.21.4283 · Cited by 46 · see citing works
Genomic organization of mouse Dishevelled genes
Yang, Y., Lijam, N., Sussman, D. J., & Tsang, M. (1996) · Gene · doi:10.1016/s0378-1119(96)00430-1 · Cited by 19 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Tsang M., Lijam, N., Yang, Y., Beier, D.R., Wynshaw-Boris, A. and Sussman, D.J. (1996) Isolation and characterization of mouse dishevelled-3. Dev. Dynam., 207, 253–262. [DOI] [PubMed] [Google Scholar]
Cited by
Sorted by citations
Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528 · see citing works
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359 · see citing works
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044 · see citing works
Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements
Veeman, M. T., Slusarski, D. C., Kaykas, A., Louie, S. H., & Moon, R. T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00240-9 · Cited by 945 · see citing works
Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation
Bilić, J., Huang, Y., Davidson, G. R., Zimmermann, T., Cruciat, C., Bienz, M., & Niehrs, C. (2007) · Science · doi:10.1126/science.1137065 · Cited by 923 · see citing works
Habas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842 · see citing works
Dishevelled controls cell polarity during Xenopus gastrulation
Wallingford, J. B., Rowning, B. A., Vogeli, K. M., Rothbächer, U., Fraser, S. E., & Harland, R. M. (2000) · Nature · doi:10.1038/35011077 · Cited by 751 · see citing works
Self-citationThe Vertebrate Primary Cilium in Development, Homeostasis, and Disease
Gerdes, J. M., Davis, E. E., & Katsanis, N. (2009) · Cell · doi:10.1016/j.cell.2009.03.023 · Cited by 700 · see citing works
β-Catenin destruction complex: insights and questions from a structural perspective
Kimelman, D., & Xu, W. (2006) · Oncogene · doi:10.1038/sj.onc.1210055 · Cited by 628 · see citing works
Wallingford, J. B., Fraser, S. E., & Harland, R. M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00197-1 · Cited by 613 · see citing works
Self-citationWong, H.-C., Bourdelas, A., Krauss, A., Lee, H., Shao, Y., Wu, D., Mlodzik, M., Shi, D., & Zheng, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00427-1 · Cited by 531 · see citing works
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
Seifert, J. R. K., & Mlodzik, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2042 · Cited by 513 · see citing works
Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D., Asashima, M., Wylie, C. C., Lin, X., & Heasman, J. (2005) · Cell · doi:10.1016/j.cell.2005.01.013 · Cited by 510 · see citing works
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509 · see citing works
Zeng, X., Huang, H., Tamai, K., Zhang, X., Harada, Y., Yokota, C., Almeida, K., Wang, J., Doble, B., Woodgett, J., et al. (2008) · Development · doi:10.1242/dev.013540 · Cited by 492 · see citing works
The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators
Rim, E. Y., Clevers, H. C., & Nusse, R. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-040320-103615 · Cited by 488 · see citing works
Wnt signaling: complexity at the surface
Cadigan, K. M., & Liu, Y. I. (2006) · Journal of Cell Science · doi:10.1242/jcs.02826 · Cited by 486 · see citing works
Park, T. J., Mitchell, B. J., Abitua, P. B., Kintner, C. R., & Wallingford, J. B. (2008) · Nature Genetics · doi:10.1038/ng.104 · Cited by 448 · see citing works
Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signalingPreprint
Axelrod, J. D. (2001) · Genes & Development · doi:10.1101/gad.890501 · Cited by 449 · see citing works
The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization
Schwarz, T., Fiedler, M., Shibata, N., Butler, P. J. G., Kikuchi, A., Higuchi, Y., & Bienz, M. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1247 · Cited by 429 · see citing works
Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation
Gong, Y., Mo, C., & Fraser, S. E. (2004) · Nature · doi:10.1038/nature02796 · Cited by 420 · see citing works
Self-citationCong, F., Schweizer, L., & VARMUS, H. E. (2004) · Development · doi:10.1242/dev.01318 · Cited by 364 · see citing works
Angers, S., Thorpe, C. J., Biechele, T. L., Goldenberg, S. J., Zheng, N., MacCoss, M. J., & Moon, R. T. (2006) · Nature Cell Biology · doi:10.1038/ncb1381 · Cited by 364 · see citing works
Neural tube closure requires Dishevelled-dependent convergent extension of the midline
Wallingford, J. B., & Harland, R. M. (2002) · Development · doi:10.1242/dev.00123 · Cited by 357 · see citing works
Wang, J., Hamblet, N. S., Mark, S., Dickinson, M. E., Brinkman, B. C., Segil, N., Fraser, S. E., Chen, P., Wallingford, J. B., & Wynshaw-Boris, A. J. (2006) · Development · doi:10.1242/dev.02347 · Cited by 355 · see citing works
Self-citationDishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L. A., Miller, W. E., Caron, M. G., Barak, L. S., Nusse, R., & Lefkowitz, R. J. (2003) · Science · doi:10.1126/science.1082808 · Cited by 334 · see citing works
Etheridge, S. L., Ray, S., Li, S., Hamblet, N. S., Lijam, N., Tsang, M., Greer, J. M., Kardos, N., Wang, J., Sussman, D. J., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000259 · Cited by 325 · see citing works
Wharton, K. A. (2003) · Developmental Biology · doi:10.1006/dbio.2002.0869 · Cited by 315 · see citing works
Umbhauer, M., Djiane, A., Goisset, C., Penzo‐Méndez, A., Riou, J., Boucaut, J., & Shi, D. (2000) · The EMBO Journal · doi:10.1093/emboj/19.18.4944 · Cited by 303 · see citing works
Essential role of non-canonical Wnt signalling in neural crest migration
Calisto, J. D., Araya, C., Marchant, L., Riaz, C. F., & Mayor, R. (2005) · Development · doi:10.1242/dev.01857 · Cited by 296 · see citing works
Ho, H. H., Susman, M. W., Bikoff, J. B., Ryu, Y. K., Jonas, A. M., Hu, L. S., Kuruvilla, R., & Greenberg, M. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200421109 · Cited by 272 · see citing works
Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish
Carreira-Barbosa, F., Concha, M. L., Takeuchi, M., Ueno, N., Wilson, S. W., & Tada, M. (2003) · Development · doi:10.1242/dev.00567 · Cited by 269 · see citing works
Frizzled-7 signalling controls tissue separation during Xenopus gastrulation
Winklbauer, R., Medina, A., Swain, R. K., & Steinbeisser, H. (2001) · Nature · doi:10.1038/35101621 · Cited by 263 · see citing works
The amniote primitive streak is defined by epithelial cell intercalation before gastrulation
Voiculescu, O., Bertocchini, F., Wolpert, L., Keller, R. E., & Stern, C. D. (2007) · Nature · doi:10.1038/nature06211 · Cited by 262 · see citing works
New Insights into the Mechanism of Wnt Signaling Pathway Activation
Kikuchi, A., Yamamoto, H., Sato, A., & Matsumoto, S. (2011) · International review of cytology · doi:10.1016/b978-0-12-386035-4.00002-1 · Cited by 259 · see citing works
Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28
Le, P. N., McDermott, J. D., & Jimeno, A. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.08.005 · Cited by 253 · see citing works
Frizzled signalling and cell polarisation inDrosophilaand vertebrates
Strutt, D. I. (2003) · Development · doi:10.1242/dev.00695 · Cited by 243 · see citing works
Maternal factors in zebrafish development
Pelegri, F. J. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10390 · Cited by 242 · see citing works
Wnt signalling in lung development and diseases
Pongracz, J. E., & Stockley, R. A. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-15 · Cited by 242 · see citing works
Tauriello, D. V. F., Jordens, I., Kirchner, K., Slootstra, J. W., Kruitwagen, T., Bouwman, B. A. M., Noutsou, M., Rüdiger, S., Schwamborn, K., Schambony, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114802109 · Cited by 227 · see citing works
Goto, T., & Keller, R. E. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0673 · Cited by 229 · see citing works
Ohkawara, B., Glinka, A., & Niehrs, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.01.006 · Cited by 226 · see citing works
Dynamic recruitment of axin by Dishevelled protein assemblies
Schwarz, T., Metcalfe, C., & Bienz, M. (2007) · Journal of Cell Science · doi:10.1242/jcs.002956 · Cited by 225 · see citing works
Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex
Gao, Z.-H., Seeling, J. M., Hill, V., Yochum, A., & Virshup, D. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032468199 · Cited by 225 · see citing works
Alternative Wnt Pathways and ReceptorsPreprint
van Amerongen, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007914 · Cited by 220 · see citing works
Wallingford, J. B., & Harland, R. M. (2001) · Development · doi:10.1242/dev.128.13.2581 · Cited by 217 · see citing works
Jenny, A., Reynolds-Kenneally, J., Das, G., Burnett, M., & Mlodzik, M. (2005) · Nature Cell Biology · doi:10.1038/ncb1271 · Cited by 218 · see citing works
Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling
Itoh, K., Brott, B. K., Bae, G.-U., Ratcliffe, M. J., & Sokol, S. Y. (2005) · Journal of Biology · doi:10.1186/jbiol20 · Cited by 221 · see citing works
Tauriello, D. V. F., Haegebarth, A., Kuper, I., Edelmann, M. J., Henraat, M., van Dijk, M. R., Kessler, B. M., Clevers, H. C., & Maurice, M. M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.035 · Cited by 218 · see citing works
The way Wnt works: Components and mechanism
Saito‐Diaz, K., Chen, T. W., Wang, X., Thorne, C. A., Wallace, H. A., Page, A. W., & Lee, E. N. (2012) · Growth Factors · doi:10.3109/08977194.2012.752737 · Cited by 215 · see citing works
Schwarz, T., Merrifield, C. J., Nichols, B. J., & Bienz, M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02646 · Cited by 214 · see citing works
WNT11 acts as a directional cue to organize the elongation of early muscle fibres
Gros, J., Serralbo, O., & Marcelle, C. (2008) · Nature · doi:10.1038/nature07564 · Cited by 210 · see citing works
Dishevelled and Wnt signaling: is the nucleus the final frontier?
Habas, R., & Dawid, I. B. (2005) · Journal of Biology · doi:10.1186/jbiol22 · Cited by 211 · see citing works
Burstyn‐Cohen, T., Stanleigh, J., Sela‐Donenfeld, D., & Kalcheim, C. (2004) · Development · doi:10.1242/dev.01424 · Cited by 207 · see citing works
Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled
Grandy, D. K., Shan, J., Zhang, X., Rao, S., Akunuru, S., Li, H., Zhang, Y. H., Alpatov, I. V., Zhang, X. A., Lang, R. A., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.009647 · Cited by 201 · see citing works
Yin, C., Kiskowski, M. A., Pouille, P., Farge, E., & Solnica‐Krezel, L. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200704150 · Cited by 193 · see citing works
Jiang, X., Charlat, O., Zamponi, R., Yang, Y., & Cong, F. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.015 · Cited by 192 · see citing works
The DIX domain targets dishevelled to actin stress fibres and vesicular membranes
Capelluto, D. G. S., Kutateladze, T. G., Habas, R., Finkielstein, C. V., He, X., & Overduin, M. (2002) · Nature · doi:10.1038/nature01056 · Cited by 190 · see citing works
Marsden, M., & DeSimone, D. W. (2001) · Development · doi:10.1242/dev.128.18.3635 · Cited by 184 · see citing works
Shimada, Y., Usui, T., Yanagawa, S.-I., Takeichi, M., & Uemura, T. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00233-0 · Cited by 186 · see citing works
Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled
Gammons, M. V. R., Renko, M., Johnson, C. M., Rutherford, T. J., & Bienz, M. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.026 · Cited by 184 · see citing works
Wei, Q., Yokota, C., Semënov, M. V., Doble, B. W., Woodgett, J. R., & He, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701927200 · Cited by 182 · see citing works
González‐Sancho, J. M., Brennan, K. R., Castelo‐Soccio, L. A., & Brown, A. M. C. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4757-4768.2004 · Cited by 182 · see citing works
Simons, M., Gault, W. J., Gotthardt, D. N., Rohatgi, R., Klein, T. J., Shao, Y., Lee, H., Wu, A.-L., Fang, Y., Satlin, L. M., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1836 · Cited by 178 · see citing works
Neural crest regulates myogenesis through the transient activation of NOTCH
Rios, A. C., Serralbo, O., Salgado, D., & Marcelle, C. (2011) · Nature · doi:10.1038/nature09970 · Cited by 179 · see citing works
Puech, P., Taubenberger, A. V., Ulrich, F., Krieg, M., Müller, D. J., & Heisenberg, C. (2005) · Journal of Cell Science · doi:10.1242/jcs.02547 · Cited by 175 · see citing works
Kinoshita, N., Iioka, H., Miyakoshi, A., & Ueno, N. (2003) · Genes & Development · doi:10.1101/gad.1101303 · Cited by 173 · see citing works
Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin
Kim, S. W., Park, J., Spring, C. M., Sater, A. K., Ji, H. L., Otchere, A. A., Daniel, J. M., & McCrea, P. D. (2004) · Nature Cell Biology · doi:10.1038/ncb1191 · Cited by 171 · see citing works
Phosphorylation of Threonine 3
Aiken, C. T., Steffan, J. S., Guerrero, C., Khashwji, H., Lukácsovich, T., Simmons, D. A., Purcell, J., Menhaji, K., Zhu, Y., Green, K., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.013193 · Cited by 172 · see citing works
Antero-posterior tissue polarity links mesoderm convergent extension to axial patterning
Ninomiya, H., Elinson, R. P., & Winklbauer, R. (2004) · Nature · doi:10.1038/nature02620 · Cited by 164 · see citing works
Inhibition of Wnt signaling by Dishevelled PDZ peptides
Zhang, Y., Appleton, B. A., Wiesmann, C., Lau, T., Costa, M., Hannoush, R. N., & Sidhu, S. S. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.152 · Cited by 163 · see citing works
Regulation of Wnt/β‐catenin signaling by protein kinases
Verheyen, E. M., & Gottardi, C. J. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22019 · Cited by 158 · see citing works
Li, Y., Rankin, S. A., Sinner, D. I., Kenny, A. P., Krieg, P. A., & Zorn, A. M. (2008) · Genes & Development · doi:10.1101/gad.1687308 · Cited by 157 · see citing works
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway.
Zheng, J., Wong, H. C., Mao, J., Nguyen, J. T., Srinivas, S., Zhang, W., Liu, B., Li, L., & Wu, D. (2000) · Nature Structural Biology · doi:10.1038/82047 · Cited by 157 · see citing works
Wei, W., Li, M., Wang, J., Nie, F., & Li, L. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00251-12 · Cited by 151 · see citing works
PTK7 recruits dsh to regulate neural crest migration
Shnitsar, I., & Borchers, A. (2008) · Development · doi:10.1242/dev.023556 · Cited by 145 · see citing works
Muñoz, R., Moreno, M., Oliva, C., Orbenes, C., & Larraı́n, J. (2006) · Nature Cell Biology · doi:10.1038/ncb1399 · Cited by 144 · see citing works
Multiple Wnt Signaling Pathways Converge to Orient the Mitotic Spindle in Early C. elegans Embryos
Walston, T., Tuskey, C., Edgar, L. G., Hawkins, N., Ellis, G. C., Bowerman, B. A., Wood, W. B., & Hardin, J. D. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.10.008 · Cited by 144 · see citing works
Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled
Cong, F., Schweizer, L., & VARMUS, H. E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.2000-2011.2004 · Cited by 142 · see citing works
Similarities between the Hedgehog and Wnt signaling pathways
Kalderon, D. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02388-7 · Cited by 141 · see citing works
Weitzel, H. E., Illies, M. R., Byrum, C. A., Xu, R., Wikramanayake, A. H., & Ettensohn, C. A. (2004) · Development · doi:10.1242/dev.01152 · Cited by 141 · see citing works
Rothbächer, U., Bertrand, V., Lamy, C., & Lemaire, P. (2007) · Development · doi:10.1242/dev.010850 · Cited by 140 · see citing works
Self-citationLee, P. N., Kumburegama, S., Marlow, H. Q., Martindale, M. Q., & Wikramanayake, A. H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.05.040 · Cited by 135 · see citing works
Cell movement during chick primitive streak formation
Chuai, M., Zeng, W., Yang, X., Boychenko, V., Glazier, J. A., & Weijer, C. J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.04.451 · Cited by 131 · see citing works
Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane
Witzel, S., Zimyanin, V. L., Carreira-Barbosa, F., Tada, M., & Heisenberg, C. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200606017 · Cited by 130 · see citing works
Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism
Tanigawa, S., Wang, H., Yang, Y., Sharma, N. D., Tarasova, N. I., Ajima, R., Yamaguchi, T. P., Rodríguez, L. G., & Perantoni, A. O. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.01.012 · Cited by 125 · see citing works
Inhibition of the Wnt Signaling Pathway by Idax, a Novel Dvl-Binding Protein
Hino, S.-I., Kishida, S., Michiue, T., Fukui, A., Sakamoto, I., Takada, S., Asashima, M., & Kikuchi, A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.330-342.2001 · Cited by 127 · see citing works
Subcellular Localization and Signaling Properties of Dishevelled in Developing Vertebrate Embryos
Park, T. J., Gray, R. S., Sato, A., Habas, R., & Wallingford, J. B. (2005) · Current Biology · doi:10.1016/j.cub.2005.04.062 · Cited by 119 · see citing works
Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes
Li, Y., & Dudley, A. T. (2009) · Development · doi:10.1242/dev.023820 · Cited by 127 · see citing works
Schweizer, L., & VARMUS, H. E. (2003) · BMC Cell Biology · doi:10.1186/1471-2121-4-4 · Cited by 125 · see citing works
Wada, H., Tanaka, H., Nakayama, S., Iwasaki, M., & Okamoto, H. (2006) · Development · doi:10.1242/dev.02665 · Cited by 119 · see citing works
Synergistic Activation of the Wnt Signaling Pathway by Dvl and Casein Kinase Iε
Kishida, M., Hino, S.-I., Michiue, T., Yamamoto, H., Kishida, S., Fukui, A., Asashima, M., & Kikuchi, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103555200 · Cited by 119 · see citing works
Ossipova, O., Dhawan, S., Sokol, S., & Green, J. B. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.011 · Cited by 113 · see citing works
Cystic Kidney Gene seahorse Regulates Cilia-Mediated Processes and Wnt Pathways
Kishimoto, N., Cao, Y., Park, A., & Sun, Z. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.010 · Cited by 116 · see citing works
Frodo interacts with Dishevelled to transduce Wnt signals
Gloy, J., Hikasa, H., & Sokol, S. Y. (2002) · Nature Cell Biology · doi:10.1038/ncb784 · Cited by 113 · see citing works
GSK-3: New Thoughts on an Old Enzyme
Ferkey, D. M., & Kimelman, D. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9816 · Cited by 113 · see citing works
The many roles of PTK7: A versatile regulator of cell–cell communication
Peradziryi, H., Tolwinski, N. S., & Borchers, A. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.12.019 · Cited by 111 · see citing works
The Casein Kinase I Family in Wnt Signaling
McKay, R. M., Peters, J. M., & Graff, J. M. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0308 · Cited by 111 · see citing works
Christensen, N. R., Čalyševa, J., Fernandes, E. F. A., Lüchow, S., Clemmensen, L. S., Haugaard‐Kedström, L. M., & Strømgaard, K. (2019) · Advanced Therapeutics · doi:10.1002/adtp.201800143 · Cited by 108 · see citing works
Zebrafish Gastrulation: Cell Movements, Signals, and Mechanisms
Rohde, L. A., & Heisenberg, C. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)61004-3 · Cited by 107 · see citing works
- Authors
- Rothbächer, U., Laurent, M. N., Deardorff, M. A., Klein, P. S., Cho, K. W. Y., & Fraser, S. E.
- Affiliations
- California Institute of Technology (US)
- University of California, Irvine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Rothbächer, Ute
- Fraser, Scott E.
- Venue
- The EMBO Journal
- Published
- 2000-03-01
- Volume
- 19
- Issue
- 5
- Pages
- 1010-1022
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC305640
- OpenAlex
- W2149429346
- Cited by
- 299
- References
- 66
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 9 · 2012: 17
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- Boehringer Ingelheim Fonds
- National Institutes of Health (5r01hd025390-09, 5p50mh049176-10)
- National Institute of Mental Health (MH49176)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-29507, R01HD029507, HD25390)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Dishevelled, Frizzled receptors, dorsoventral patterning, protein phosphorylation, membrane translocation, subcellular localization, DIX domain, DEP domain, protein oligomerization, Wnt signaling, Xenopus embryo
- MeSH terms
- Dishevelled Proteins, Animals, Biological Transport, Embryo, Nonmammalian, Phosphoproteins, Phosphorylation, Xenopus, Gene Expression Regulation, Developmental, Insect Proteins, Xenopus Proteins, Adaptor Proteins, Signal Transducing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review