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Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis?

Boquet, Patrice, Lemichez, Emmanuel·2003·Trends in Cell Biology
DOI 10.1016/s0962-8924(03)00037-0
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Abstract

In the past few years, an important question in microbiology has arisen from reports indicating that several pathogenic bacteria have evolved virulence factors directed towards a Ras subfamily of GTPases, namely the Rho GTPases. Progress made in studying both the virulence factors and the signaling pathways involving Rho GTPases has shed light on this crosstalk. One central question is raised by the findings that both activating and inactivating virulence factors that target Rho GTPases coexist in some pathogenic bacteria. Further studies on this peculiar aspect of the bacteria-host cell interactions, which leads to the outbreak of infectious diseases, might clarify whether this aspect of Rho GTPase activation or inactivation represents a finely adapted response of the pathogen for its own benefit or might lead to a reaction of the host against the bacteria.

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Metadata

Authors
Boquet, P., & Lemichez, E.
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2003-05
Volume
13
Issue
5
Pages
238-246
ISSN
0962-8924
DOI
10.1016/s0962-8924(03)00037-0
Cited by
149
References
2
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis? https://app.cochat.ai/papers/10.1016/s0962-8924(03)00037-0
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Boquet, P., & Lemichez, E. (2003). Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis? Trends in Cell Biology. https://doi.org/10.1016/s0962-8924(03)00037-0