MAP Kinase Translocates into the Nucleus of the Presynaptic Cell and Is Required for Long-Term Facilitation in Aplysia

A synaptic model of memory: long-term potentiation in the hippocampus

Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

Marshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 4,557 · see citing works

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27489 · Cited by 3,396 · see citing works

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., & Saltiel, A. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7686 · Cited by 2,679 · see citing works

Synaptic tagging and long-term potentiation

Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736 · see citing works

Protein synthesis and memory: A review.

Davis, H. P., & Squire, L. R. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.96.3.518 · Cited by 1,505 · see citing works

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

Xing, J. W., Ginty, D. D., & Greenberg, M. E. (1996) · Science · doi:10.1126/science.273.5277.959 · Cited by 1,246 · see citing works

Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons

Frey, U., Huang, Y.-Y., & Kandel, E. R. (1993) · Science · doi:10.1126/science.8389057 · Cited by 1,218 · see citing works

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

Abel, T., Nguyen, P. V., Barad, M., Deuel, T. A. S., Kandel, E. R., & Bourtchouladze, R. (1997) · Cell · doi:10.1016/s0092-8674(00)81904-2 · Cited by 1,217 · see citing works

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

Vossler, M. R., Yao, H. W., York, R. D., Pan, M., Rim, C. S., & Stork, P. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80184-1 · Cited by 1,044 · see citing works

The long and the short of long–term memory—a molecular framework

Goelet, P., Castellucci, V. F., Schacher, S., & Kandel, E. R. (1986) · Nature · doi:10.1038/322419a0 · Cited by 1,041 · see citing works

Inhibition by cAMP of Ras-Dependent Activation of Raf

Cook, S. J., & McCormick, F. P. (1993) · Science · doi:10.1126/science.7694367 · Cited by 942 · see citing works

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

Nguyen, P. V., Abel, T., & Kandel, E. R. (1994) · Science · doi:10.1126/science.8066450 · Cited by 888 · see citing works

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

Traverse, S., Gómez, N., Paterson, H., Marshall, C. J., & Cohen, P. (1992) · Biochemical Journal · doi:10.1042/bj2880351 · Cited by 874 · see citing works

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in <i>Aplysia</i>

Montarolo, P. G., Goelet, P., Castellucci, V. F., Morgan, J., Kandel, E. R., & Schacher, S. (1986) · Science · doi:10.1126/science.3775383 · Cited by 769 · see citing works

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

Dash, P. K., Hochner, B., & Kandel, E. R. (1990) · Nature · doi:10.1038/345718a0 · Cited by 747 · see citing works

Toward a molecular definition of long-term memory storage

Bailey, C. H., Bartsch, D., & Kandel, E. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13445 · Cited by 691 · see citing works

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

Lin, T.-A., Kong, X., Haystead, T., Pause, A., Belsham, G. J., Sonenberg, N., & Lawrence, J. C. (1994) · Science · doi:10.1126/science.7939721 · Cited by 671 · see citing works

Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP

Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A., & Nicoll, R. A. (1994) · Science · doi:10.1126/science.7916482 · Cited by 618 · see citing works

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

Ferrell, J. E. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20026-x · Cited by 591 · see citing works

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

English, J. D., & Sweatt, J. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24329 · Cited by 579 · see citing works

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

Nakajima, T., Kinoshita, S. M., Sasagawa, T., Sasaki, K., Naruto, M., Kishimoto, T., & Akira, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2207 · Cited by 578 · see citing works

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

Bartsch, D., Ghirardi, M., Skehel, P. A., Karl, K. A., Herder, S. P., Chen, M., Bailey, C. H., & Kandel, E. R. (1995) · Cell · doi:10.1016/0092-8674(95)90213-9 · Cited by 572 · see citing works

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

Bacskai, B. J., Hochner, B., Mahaut‐Smith, M. P., Adams, S., Kaang, B., Kandel, E. R., & Tsien, R. Y. (1993) · Science · doi:10.1126/science.7682336 · Cited by 546 · see citing works

C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia

Alberini, C. M., Ghirardl, M., Metz, R., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90386-7 · Cited by 523 · see citing works

cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase

Huang, Y.-Y., Li, X.-C., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90401-4 · Cited by 490 · see citing works

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

Faure, M., Voyno-Yasenetskaya, T., & Bourne, H. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37127-2 · Cited by 476 · see citing works

Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.Preprint

Huang, Y.-Y., & Kandel, E. R. (1994) · Learning & Memory · doi:10.1101/lm.1.1.74 · Cited by 476 · see citing works

Diversity in function and regulation of MAP kinase pathways

BLUMER, K. J., & Johnson, G. L. (1994) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(94)90147-3 · Cited by 465 · see citing works

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

Bading, H., & Greenberg, M. E. (1991) · Science · doi:10.1126/science.1715095 · Cited by 463 · see citing works

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases.

Gonzalez, F. A., Raden, D. L., & Davis, R. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54548-8 · Cited by 454 · see citing works

Carboxypeptidase E Is a Regulated Secretory Pathway Sorting Receptor: Genetic Obliteration Leads to Endocrine Disorders in Cpefat Mice

Cool, D. R., Normant, E., Shen, F.-S., Chen, H., Pannell, L. K., Zhang, Y., & Loh, Y. P. (1997) · Cell · doi:10.1016/s0092-8674(00)81860-7 · Cited by 449 · see citing works

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

Graves, L. M., Bornfeldt, K., Raines, E. W., Potts, B. C. M., Macdonald, S. G., Ross, R., & Krebs, E. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10300 · Cited by 447 · see citing works

Morphological Basis of Long-Term Habituation and Sensitization in Aplysia

Bailey, C. H., & Chen, M. (1983) · Science · doi:10.1126/science.6828885 · Cited by 420 · see citing works

Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase

Clark‐Lewis, I., Sanghera, J. S., & Pelech, S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98601-1 · Cited by 406 · see citing works

Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia

Mayford, M. R., Barzilai, A., Keller, F., Schacher, S., & Kandel, E. R. (1992) · Science · doi:10.1126/science.1585176 · Cited by 371 · see citing works

Genetic Dissection of Structural and Functional Components of Synaptic Plasticity. II. Fasciclin II Controls Presynaptic Structural Plasticity

Schuster, C., Davis, G. W., Fetter, R. D., & Goodman, C. S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80198-1 · Cited by 371 · see citing works

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

Sevetson, B. R., Kong, X., & Lawrence, J. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10305 · Cited by 366 · see citing works

Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.

Frödin, M., Peraldi, P., & Obberghen‐Schilling, E. V. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37589-0 · Cited by 326 · see citing works

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

González, F. M., Seth, A., Raden, D. L., Bowman, D., Fay, F., & Davis, R. J. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.5.1089 · Cited by 320 · see citing works

Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia

Bailey, C. H., Chen, M., Keller, F., & Kandel, E. R. (1992) · Science · doi:10.1126/science.1585177 · Cited by 314 · see citing works

Quantal analysis and synaptic anatomy--integrating two views of hippocampal plasticity.

Lisman, J., & Harris, K. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90122-3 · Cited by 271 · see citing works

Dissection of memory formation: from behavioral pharmacology to molecular genetics

DeZazzo, J., & Tully, T. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93905-d · Cited by 270 · see citing works

Induction of long-term potentiation is associated with major ultrastructural changes of activated synapses.

Buchs, P., & Müller, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.8040 · Cited by 267 · see citing works

cAMP Evokes Long-Term Facilitation in Aplysia Sensory Neurons That Requires New Protein Synthesis

Schacher, S., Castellucci, V. F., & Kandel, E. R. (1988) · Science · doi:10.1126/science.2454509 · Cited by 264 · see citing works

The Signal-Dependent Coactivator CBP Is a Nuclear Target for pp90RSK

Nakajima, T., Fukamizu, A., Takahashi, J. B., Gage, F. H., Fisher, T., Blenis, J., & Montminy, M. (1996) · Cell · doi:10.1016/s0092-8674(00)80119-1 · Cited by 254 · see citing works

Inhibitor of protein synthesis blocks longterm behavioral sensitization in the isolated gill‐withdrawal reflex of Aplysia

Castellucci, V. F., Blumenfeld, H., Goelet, P., & Kandel, E. R. (1989) · Journal of Neurobiology · doi:10.1002/neu.480200102 · Cited by 232 · see citing works

Genetic Dissection of Structural and Functional Components of Synaptic Plasticity. III. CREB Is Necessary for Presynaptic Functional Plasticity

Davis, G. W., Schuster, C., & Goodman, C. S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80199-3 · Cited by 230 · see citing works

Target-Dependent Structural Changes Accompanying Long-Term Synaptic Facilitation in Aplysia Neurons

Glanzman, D. L., Kandel, E. R., & Schacher, S. (1990) · Science · doi:10.1126/science.2389145 · Cited by 224 · see citing works

Molecular Enhancement of Memory Formation

Carew, T. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80016-1 · Cited by 202 · see citing works

Role of Transforming Growth Factor-β in Long-Term Synaptic Facilitation in Aplysia

Zhang, F., Endo, S., Cleary, L. J., Eskin, A., & Byrne, J. H. (1997) · Science · doi:10.1126/science.275.5304.1318 · Cited by 186 · see citing works

Spatial and temporal changes in signal transduction pathways during LTP

Thomas, K. L., Laroche, S., Errington, M. L., Bliss, T. V. P., & Hunt, S. P. (1994) · Neuron · doi:10.1016/0896-6273(94)90040-x · Cited by 182 · see citing works

Mutation in the Phosphorylation Sites of MAP Kinase Blocks Learning-Related Internalization of apCAM in Aplysia Sensory Neurons

Bailey, C. H., Kaang, B., Chen, M., Martin, K. C., Lim, C., Casadio, A., & Kandel, E. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80331-1 · Cited by 180 · see citing works

Anatomy and electrophysiology of fast central synapses lead to a structural model for long-term potentiation

Edwards, F. A. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.4.759 · Cited by 179 · see citing works

Synaptic plasticity in vitro: cell culture of identified Aplysia neurons mediating short-term habituation and sensitization

Rayport, S., & Schacher, S. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-03-00759.1986 · Cited by 177 · see citing works

p42 mitogen-activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites

Fiore, R. S., Bayer, V. E., Pelech, S., Posada, J. A., Cooper, J. A., & Baraban, J. M. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90516-i · Cited by 158 · see citing works

B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.

Vaillancourt, R. R., Gardner, A. M., & Johnson, G. L. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6522 · Cited by 157 · see citing works

Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts.

Brondello, J., McKenzie, F. R., Sun, H., Tonks, N. K., & Pouysségur, J. (1995) · PubMed · Cited by 154 · see citing works

Synapse restructuring associated with the maintenance phase of hippocampal long-term potentiation

Geinisman, Y., deToledo‐Morrell, L., Morrell, F., Persina, I. S., & Beatty, M. A. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960506)368:3 · Cited by 140 · see citing works

Long-term sensitization in Aplysia increases the number of presynaptic contacts onto the identified gill motor neuron L7.

Bailey, C. H., & Chen, M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9356 · Cited by 121 · see citing works

Long-Term Facilitation in Aplysia Involves Increase in Transmitter Release

Dale, N., Schacher, S., & Kandel, E. R. (1988) · Science · doi:10.1126/science.2892269 · Cited by 116 · see citing works

Protein Serine/Threonine Kinases of the MAPK Cascade

Graves, J. D., Campbell, J. S., & Krebs, E. G. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb26684.x · Cited by 86 · see citing works

Differential effects on cAMP on the MAP kinase cascade: evidence for a cAMP-insensitive step that can bypass Raf-1.

Faure, M., & Bourne, H. R. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.8.1025 · Cited by 68 · see citing works

Discussion

Sossin, W. S. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)20016-5 · Cited by 63 · see citing works

Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells

Gause, K. C., Homma, M. K., Licciardi, K. A., Seger, R., Ahn, N. G., Peterson, M. J., Krebs, E. G., & Meier, K. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85398-x · Cited by 59 · see citing works

Cyclic Adenosine Monophosphate Can Convert Epidermal Growth Factor into a Differentiating Factor in Neuronal Cells

Yao, H. W., Labudda, K., Rim, C. S., Capodieci, P., Loda, M. F., & Stork, P. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20748 · Cited by 54 · see citing works

Temporal and spatial regulation of the expression of BAD2, a MAP kinase phosphatase, during seizure, kindling, and long-term potentiation.Preprint

Qian, Z., Gilbert, M. E., & Kandel, E. R. (1994) · Learning & Memory · doi:10.1101/lm.1.3.180 · Cited by 30 · see citing works

The molecular biology of memory storage: a dialogue between genes and synapses

Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917 · see citing works

Neuronal Calcium Signaling

Berridge, M. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80510-3 · Cited by 2,189 · see citing works

Long-Term Potentiation and Memory

Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,001 · see citing works

Cognitive Neuroscience and the Study of Memory

Milner, B. A., Squire, L. R., & Kandel, E. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80987-3 · Cited by 1,300 · see citing works

Addiction, Dopamine, and the Molecular Mechanisms of Memory

Berke, J. D., & Hyman, S. E. (2000) · Neuron · doi:10.1016/s0896-6273(00)81056-9 · Cited by 1,167 · see citing works

The Molecular and Systems Biology of Memory

Kandel, E. R., Dudai, Y., & Mayford, M. R. (2014) · Cell · doi:10.1016/j.cell.2014.03.001 · Cited by 1,134 · see citing works

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

Sweatt, J. D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00054.x · Cited by 1,131 · see citing works

The MAPK cascade is required for mammalian associative learning

Atkins, C. M., Selcher, J. C., Petraitis, J. J., Trzaskos, J. M., & Sweatt, J. D. (1998) · Nature Neuroscience · doi:10.1038/2836 · Cited by 1,083 · see citing works

Mitogen-activated protein kinases in synaptic plasticity and memory

Sweatt, J. D. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.04.001 · Cited by 990 · see citing works

Transcription Factors in Long-Term Memory and Synaptic Plasticity

Alberini, C. M. (2009) · Physiological Reviews · doi:10.1152/physrev.00017.2008 · Cited by 991 · see citing works

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

Kandel, E. R. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-14 · Cited by 904 · see citing works

Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

Impey, S., Obrietan, K. H., Wong, S. T., Poser, S., Yano, S., Wayman, G. A., Deloulme, J., Chan, G. C. ‐., & Storm, D. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80602-9 · Cited by 889 · see citing works

MAP kinase pathways

Cobb, M. H. (1999) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(98)00056-x · Cited by 869 · see citing works

Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity

Ji, R., Baba, H., Brenner, G. J., & Woolf, C. J. (1999) · Nature Neuroscience · doi:10.1038/16040 · Cited by 782 · see citing works

Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage.

Martin, K. C., Casadio, A., Zhu, H.-X., Yaping, E., Rose, J. C., Chen, M. C., Bailey, C. H., & Kandel, E. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80484-5 · Cited by 752 · see citing works

The Restless Engram: Consolidations Never End

Dudai, Y. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150500 · Cited by 644 · see citing works

Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning

Schafe, G. E., Atkins, C. M., Swank, M. W., Bauer, E. P., Sweatt, J. D., & LeDoux, J. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08177.2000 · Cited by 674 · see citing works

The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response Element-Binding Protein to Control Long-Term Potentiation-Dependent Gene Expression in the Dentate GyrusIn Vivo

Davis, S., Vanhoutte, P., Pagès, C., Caboche, J., & Laroche, S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04563.2000 · Cited by 621 · see citing works

Making New Connections

Impey, S., Obrietan, K. H., & Storm, D. R. (1999) · Neuron · doi:10.1016/s0896-6273(00)80747-3 · Cited by 613 · see citing works

Nuclear translocation of p42/p44 mitogen‐activated protein kinase is required for growth factor‐induced gene expression and cell cycle entry

Brunet, A., Roux, D., Lenormand, P., Dowd, S., Keyse, S. M., & Pouysségur, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.664 · Cited by 595 · see citing works

Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory

Adams, J. P., & Sweatt, J. D. (2002) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.082701.145401 · Cited by 588 · see citing works

Extracellular-signal-regulated kinase signalling in neurons

Grewal, S., York, R. D., & Stork, P. A. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00010-0 · Cited by 555 · see citing works

Involvement of the Extracellular Signal-Regulated Kinase Cascade for Cocaine-Rewarding Properties

Valjent, E., Corvol, J., Pagès, C., Besson, M., Maldonado, R. J., & Caboche, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08701.2000 · Cited by 548 · see citing works

The Mitogen-Activated Protein Kinase Cascade Couples PKA and PKC to cAMP Response Element Binding Protein Phosphorylation in Area CA1 of Hippocampus

Roberson, E. D., English, J. D., Adams, J. P., Selcher, J. C., Kondratick, C. M., & Sweatt, J. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04337.1999 · Cited by 542 · see citing works

A Mitogen-Activated Protein Kinase Cascade in the CA1/CA2 Subfield of the Dorsal Hippocampus Is Essential for Long-Term Spatial Memory

Blum, S., Moore, A. N., Adams, F., & Dash, P. K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03535.1999 · Cited by 522 · see citing works

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons

Holt, C. E., & Schuman, E. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.036 · Cited by 525 · see citing works

Depolarization and cAMP Elevation Rapidly Recruit TrkB to the Plasma Membrane of CNS Neurons

Meyer-Franke, A., Wilkinson, G. A., Kruttgen, A., Hu, M., Munro, E., Hanson, M. G., Reichardt, L. F., & Barres, B. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80586-3 · Cited by 516 · see citing works

Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective

Schafe, G. E., Nader, K., Blair, H. T., & LeDoux, J. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01969-x · Cited by 510 · see citing works

A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis

Casadio, A., Martin, K. C., Giustetto, M., Zhu, H., Chen, M., Bartsch, D., Bailey, C. H., & Kandel, E. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81653-0 · Cited by 503 · see citing works

Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure

Guan, Z., Giustetto, M., Lomvardas, S., Kim, J.-H., Miniaci, M. C., Schwartz, J. H., Thanos, D., & Kandel, E. R. (2002) · Cell · doi:10.1016/s0092-8674(02)01074-7 · Cited by 497 · see citing works

Molecular mechanisms underlying emotional learning and memory in the lateral amygdala

Rodrigues, S. M., Schafe, G. E., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.014 · Cited by 491 · see citing works

Calcium-Stimulated Adenylyl Cyclase Activity Is Critical for Hippocampus-Dependent Long-Term Memory and Late Phase LTP

Wong, S. T., Athos, J., Figueroa, X. A., Pineda, V. V., Schaefer, M. L., Chavkin, C. C., Muglia, L. J., & Storm, D. R. (1999) · Neuron · doi:10.1016/s0896-6273(01)80036-2 · Cited by 486 · see citing works

Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway

Wu, G., Deisseroth, K. A., & Tsien, R. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051634198 · Cited by 477 · see citing works

Molecular Substrates for Retrieval and Reconsolidation of Cocaine-Associated Contextual Memory

Miller, C. A., & Marshall, J. F. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.006 · Cited by 467 · see citing works

Reversible Inhibition of CREB/ATF Transcription Factors in Region CA1 of the Dorsal Hippocampus Disrupts Hippocampus-Dependent Spatial Memory

Pittenger, C., Huang, Y. Y., Paletzki, R. F., Bourtchouladze, R., Scanlin, H., Vronskaya, S., & Kandel, E. R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00684-0 · Cited by 464 · see citing works

Mathematical modeling of gene networks.

Smolen, P., Baxter, D., & Byrne, J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81194-0 · Cited by 466 · see citing works

Nitric Oxide Signaling Contributes to Late-Phase LTP and CREB Phosphorylation in the Hippocampus

Lü, Y.-F., Kandel, E. R., & Hawkins, R. D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-23-10250.1999 · Cited by 409 · see citing works

Characterization of Small RNAs in Aplysia Reveals a Role for miR-124 in Constraining Synaptic Plasticity through CREB

Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., & Kandel, E. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.029 · Cited by 406 · see citing works

Memory Consolidation for Contextual and Auditory Fear Conditioning Is Dependent on Protein Synthesis, PKA, and MAP KinasePreprint

Schafe, G. E., Nadel, N. V., Sullivan, G. M., Harris, A. Z., & LeDoux, J. E. (1999) · Learning & Memory · doi:10.1101/lm.6.2.97 · Cited by 407 · see citing works

Structural Components of Synaptic Plasticity and Memory ConsolidationPreprint

Bailey, C. H., Kandel, E. R., & Harris, K. M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021758 · Cited by 393 · see citing works

Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology

Wu, G., Deisseroth, K. A., & Tsien, R. W. (2001) · Nature Neuroscience · doi:10.1038/83976 · Cited by 389 · see citing works

Is Heterosynaptic modulation essential for stabilizing hebbian plasiticity and memory

Bailey, C. H., Giustetto, M., Huang, Y.-Y., Hawkins, R. D., & Kandel, E. R. (2000) · Nature Reviews Neuroscience · doi:10.1038/35036191 · Cited by 382 · see citing works

CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation

Bartsch, D., Casadio, A., Karl, K. A., Serodio, P., & Kandel, E. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81752-3 · Cited by 373 · see citing works

Downregulation of Transient K+Channels in Dendrites of Hippocampal CA1 Pyramidal Neurons by Activation of PKA and PKC

Hoffman, D. A., & Johnston, D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03521.1998 · Cited by 373 · see citing works

Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 That Are Inducible by MAPK

Dalby, K. N., MORRICE, N. A., Caudwell, F. B., Avruch, J., & Cohen, P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1496 · Cited by 373 · see citing works

The Regulation of Transcription in Memory Consolidation

Alberini, C. M., & Kandel, E. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021741 · Cited by 362 · see citing works

The molecular and cellular biology of enhanced cognition

Lee, Y.-S., & Silva, A. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2572 · Cited by 361 · see citing works

Targeting the CREB pathway for memory enhancers

Tully, T., Bourtchouladze, R., Scott, R., & Tallman, J. F. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1061 · Cited by 355 · see citing works

MAPK activation in nociceptive neurons and pain hypersensitivity

Obata, K., & Noguchi, K. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.01.007 · Cited by 358 · see citing works

A Complex Program of Striatal Gene Expression Induced by Dopaminergic Stimulation

Berke, J. D., Paletzki, R. F., Aronson, G. J., Hyman, S. E., & Gerfen, C. R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05301.1998 · Cited by 355 · see citing works

Phosphorylation of Extracellular Signal-Regulated Kinase in Primary Afferent Neurons by Noxious Stimuli and Its Involvement in Peripheral Sensitization

Dai, Y., Iwata, K., Fukuoka, T., Kondo, E., Tokunaga, A., Yamanaka, H., Tachibana, T., Liu, Y., & Noguchi, K. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07737.2002 · Cited by 354 · see citing works

Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic–depressive illness

Manji, H. K., Moore, G. J., & Chen, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00979-3 · Cited by 352 · see citing works

Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin

Winder, D. G., Mansuy, I. M., Osman, M., Moallem, T. M., & Kandel, E. R. (1998) · Cell · doi:10.1016/s0092-8674(00)80896-x · Cited by 351 · see citing works

Signaling from synapse to nucleus: the logic behind the mechanisms

Deisseroth, K. A., Mermelstein, P. G., Xia, H., & Tsien, R. W. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00076-x · Cited by 350 · see citing works

A Necessity for MAP Kinase Activation in Mammalian Spatial Learning

Selcher, J. C., Atkins, C. M., Trzaskos, J. M., Paylor, R., & Sweatt, J. D. (1999) · Learning &amp; Memory · doi:10.1101/lm.6.5.478 · Cited by 341 · see citing works

Modeling transcriptional control in gene networks—methods, recent results, and future directions

Smolen, P., Baxter, D., & Byrne, J. (2000) · Bulletin of Mathematical Biology · doi:10.1006/bulm.1999.0155 · Cited by 386 · see citing works

ERK Plays a Regulatory Role in Induction of LTP by Theta Frequency Stimulation and Its Modulation by β-Adrenergic Receptors

Winder, D. G., Martin, K. C., Muzzio, I. A., Rohrer, D. K., Chruscinski, A. J., Kobilka, B. K., & Kandel, E. R. (1999) · Neuron · doi:10.1016/s0896-6273(00)81124-1 · Cited by 321 · see citing works

Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory

Abel, T. G., Martin, K. C., Bartsch, D., & Kandel, E. R. (1998) · Science · doi:10.1126/science.279.5349.338 · Cited by 316 · see citing works

Protein Kinase Modulation of Dendritic K+ Channels in Hippocampus Involves a Mitogen-Activated Protein Kinase Pathway

Yuan, L., Adams, J. P., Swank, M. W., Sweatt, J. D., & Johnston, D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-04860.2002 · Cited by 314 · see citing works

Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade

Cammarota, M., Bevilaqua, L. R., Ardenghi, P. G., Paratcha, G., de Stein, M. L., Izquierdo, I., & Medina, J. H. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00329-0 · Cited by 310 · see citing works

Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity

Ingi, T., Krumins, A. M., Chidiac, P., Brothers, G. M., Chung, S., Snow, B. E., Barnes, C. A., Lanahan, A. A., Siderovski, D. P., Ross, E. M., et al. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07178.1998 · Cited by 298 · see citing works

Neural recognition molecules and synaptic plasticity

Schachner, M. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80115-9 · Cited by 284 · see citing works

Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase

Patterson, S. L., Pittenger, C., Morozov, A., Martin, K. C., Scanlin, H., Drake, C., & Kandel, E. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00443-3 · Cited by 334 · see citing works

The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses

Kandel, E. R. (2004) · Bioscience Reports · doi:10.1007/s10540-005-2742-7 · Cited by 280 · see citing works

NOBEL LECTURE: The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses

Kandel, E. R. (2001) · Bioscience Reports · doi:10.1023/a:1014775008533 · Cited by 280 · see citing works

Specific and Differential Activation of Mitogen-Activated Protein Kinase Cascades by Unfamiliar Taste in the Insular Cortex of the Behaving Rat

Berman, D. E., Hazvi, S., Rosenblum, K., Seger, R., & Dudai, Y. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-10037.1998 · Cited by 280 · see citing works

The Persistence of Long-Term Memory

Bailey, C. H., Kandel, E. R., & Si, K. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.017 · Cited by 277 · see citing works

Both Protein Kinase A and Mitogen-Activated Protein Kinase Are Required in the Amygdala for the Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation

Huang, Y.-Y., Martin, K. C., & Kandel, E. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06317.2000 · Cited by 269 · see citing works

Positive and negative regulatory mechanisms that mediate long-term memory storage

Abel, T. G., & Kandel, E. R. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00050-7 · Cited by 267 · see citing works

Arg3.1/Arc mRNA Induction by Ca2+and cAMP Requires Protein Kinase A and Mitogen-Activated Protein Kinase/Extracellular Regulated Kinase Activation

Waltereit, R., Dammermann, B., Wulff, P., Scafidi, J., Staubli, U. V., Kauselmann, G., Bundman, M. C., & Kuhl, D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05484.2001 · Cited by 259 · see citing works

Structural basis for selective inhibition of Src family kinases by PP1

Liu, Y., Bishop, A. C., Witucki, L. A., Kraybill, B. C., Shimizu, E., Tsien, J. Z., Ubersax, J. A., Blethrow, J. D., Morgan, D. O., & Shokat, K. M. (1999) · Chemistry & Biology · doi:10.1016/s1074-5521(99)80118-5 · Cited by 252 · see citing works

The Inhibitory Effects of Interleukin‐6 on Synaptic Plasticity in the Rat Hippocampus Are Associated with an Inhibition of Mitogen‐Activated Protein Kinase ERK

Tancredi, V., D’Antuono, M., Café, C., Giovedı̀, S., Buè, M. C., D’Arcangelo, G., Onofri, F., & Benfenati, F. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750634.x · Cited by 249 · see citing works

Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons

Crosio, C., Heitz, E., Allis, C. D., Borrelli, E., & Sassone‐Corsi, P. (2003) · Journal of Cell Science · doi:10.1242/jcs.00804 · Cited by 242 · see citing works

Role of Phosphoinositide 3-Kinase and Endocytosis in Nerve Growth Factor-Induced Extracellular Signal-Regulated Kinase Activation via Ras and Rap1

York, R. D., Molliver, D. C., Grewal, S., Stenberg, P. E., McCleskey, E. W., & Stork, P. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8069-8083.2000 · Cited by 242 · see citing works

Rap1 Couples cAMP Signaling to a Distinct Pool of p42/44MAPK Regulating Excitability, Synaptic Plasticity, Learning, and Memory

Morozov, A., Muzzio, I. A., Bourtchouladze, R., Van-Strien, N., Lapidus, K. A. B., Yin, D., Winder, D. G., Adams, J. P., Sweatt, J. D., & Kandel, E. R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00404-5 · Cited by 237 · see citing works

Molecular Mechanisms of Memory Storage inAplysia

Hawkins, R. D., Kandel, E. R., & Bailey, C. H. (2006) · Biological Bulletin · doi:10.2307/4134556 · Cited by 231 · see citing works

A Role for Prefrontal Cortex in Memory Storage for Trace Fear Conditioning

Runyan, J. D., Moore, A. N., & Dash, P. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4880-03.2004 · Cited by 224 · see citing works

Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity

Murray, B., Alessandrini, A., Cole, A. J., Yee, A. G., & Furshpan, E. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11975 · Cited by 224 · see citing works

β-Amyloid Peptide at Sublethal Concentrations Downregulates Brain-Derived Neurotrophic Factor Functions in Cultured Cortical Neurons

Tong, L., Balazs, R., Thornton, P. L., & Cotman, C. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5463-03.2004 · Cited by 221 · see citing works

Mitogen-Activated Protein Kinase Cascade in the Basolateral Nucleus of Amygdala Is Involved in Extinction of Fear-Potentiated Startle

Lu, K., Walker, D. L., & Davis, M. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0005.2001 · Cited by 222 · see citing works

Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses

Bolshakov, V. Y., Carboni, L., Cobb, M. H., Siegelbaum, S. A., & Belardetti, F. (2000) · Nature Neuroscience · doi:10.1038/80624 · Cited by 220 · see citing works

Common molecular mechanisms in explicit and implicit memory

Barco, Á., Bailey, C. H., & Kandel, E. R. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03870.x · Cited by 217 · see citing works

Molecular Mechanisms of the Memory Trace

Asok, A., Leroy, F., Rayman, J. B., & Kandel, E. R. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.10.005 · Cited by 213 · see citing works

Mice Lacking the ERK1 Isoform of MAP Kinase Are Unimpaired in Emotional LearningPreprint

Selcher, J. C., Nekrasova, T., Paylor, R. E., Landreth, G. E., & Sweatt, J. D. (2001) · Learning & Memory · doi:10.1101/lm.37001 · Cited by 211 · see citing works

Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus

Guan, Z., Peng, X., & Fang, J. (2004) · Brain Research · doi:10.1016/j.brainres.2004.05.032 · Cited by 208 · see citing works

Functional identification of sensory mechanisms required for developmental song learning

London, S. E., & Clayton, D. F. (2008) · Nature Neuroscience · doi:10.1038/nn.2103 · Cited by 208 · see citing works

Growth Factor–induced p42/p44 MAPK Nuclear Translocation and Retention Requires Both MAPK Activation and Neosynthesis of Nuclear Anchoring Proteins

Lenormand, P., Brondello, J., Brunet, A., & Pouysségur, J. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.3.625 · Cited by 207 · see citing works

Associative Learning in Invertebrates

Hawkins, R. D., & Byrne, J. H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021709 · Cited by 199 · see citing works

Nociceptor Sensitization by Extracellular Signal-Regulated Kinases

Aley, K. O., Martin, A., McMahon, T. J., Mok, J., Levine, J. D., & Messing, R. O. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06933.2001 · Cited by 198 · see citing works

Differential Regulation of Mitogen-Activated Protein Kinases ERK1/2 and ERK5 by Neurotrophins, Neuronal Activity, and cAMP in Neurons

Cavanaugh, J. E., Ham, J., Hetman, M., Poser, S., Yan, C., & Xia, Z. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00434.2001 · Cited by 196 · see citing works

Chronic activation of ERK and neurodegenerative diseases

Colucci‐D'Amato, L., Perrone‐Capano, C., & di Porzio, U. (2003) · BioEssays · doi:10.1002/bies.10355 · Cited by 195 · see citing works

Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity

Arendt, T. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.007 · Cited by 188 · see citing works

Modulation of Presynaptic Plasticity and Learning by the H-ras/Extracellular Signal-Regulated Kinase/Synapsin I Signaling Pathway

Kushner, S. A., Elgersma, Y., Murphy, G. G., Jaarsma, D., van Woerden, G. M., Hojjati, M. R., Cui, Y., LeBoutillier, J. C., Marrone, D. F., Choi, E. S., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2836-05.2005 · Cited by 188 · see citing works

Is the Ras-MAPK signalling pathway necessary for long-term memory formation?

Orban, P. C., Chapman, P. F., & Brambilla, R. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01306-x · Cited by 186 · see citing works

Frequency selectivity, multistability, and oscillations emerge from models of genetic regulatory systems

Smolen, P., Baxter, D. A., & Byrne, J. H. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.2.c531 · Cited by 185 · see citing works

ERKI/II Regulation by the Muscarinic Acetylcholine Receptors in Neurons

Rosenblum, K., Futter, M., Jones, M. W., Hulme, E. C., & Bliss, T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-03-00977.2000 · Cited by 180 · see citing works

Mutation in the Phosphorylation Sites of MAP Kinase Blocks Learning-Related Internalization of apCAM in Aplysia Sensory Neurons

Bailey, C. H., Kaang, B., Chen, M., Martin, K. C., Lim, C., Casadio, A., & Kandel, E. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80331-1 · Cited by 180 · see citing works

ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit

Schrader, L. A., Birnbaum, S. G., Nadin, B. M., Ren, Y., Bui, D., Anderson, A. E., & Sweatt, J. D. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00358.2005 · Cited by 176 · see citing works

In search of general mechanisms for long-lasting plasticity: Aplysia and the hippocampus

Pittenger, C., & Kandel, E. R. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1247 · Cited by 174 · see citing works

Drosophila Perlecan modulates FGF and Hedgehog signals to activate neural stem cell division

Park, Y., Rangel, C., Reynolds, M., Caldwell, M. C., Johns, M., Nayak, M. S., Welsh, C. J., McDermott, S., & Datta, S. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00019-2 · Cited by 172 · see citing works

Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia

Michael, D., Martin, K. C., Seger, R., Ning, M., Baston, R., & Kandel, E. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1864 · Cited by 141 · see citing works

Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia

Ye, X., Marina, A., & Carew, T. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209956109 · Cited by 11 · see citing works

Mutation in the Phosphorylation Sites of MAP Kinase Blocks Learning-Related Internalization of apCAM in Aplysia Sensory Neurons

Bailey, C. H., Kaang, B., Chen, M., Martin, K. C., Lim, C., Casadio, A., & Kandel, E. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80331-1 · Cited by 180 · see citing works

Serotonin Regulates the Secretion and Autocrine Action of a Neuropeptide to Activate MAPK Required for Long-Term Facilitation in Aplysia

Hu, J., Glickman, L., Wu, F., & Schacher, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.011 · Cited by 72 · see citing works

Differential Role of Mitogen-Activated Protein Kinase in Three Distinct Phases of Memory for Sensitization in<i>Aplysia</i>

Sharma, S. K., Sherff, C. M., Shobe, J., Bagnall, M. W., Sutton, M. A., & Carew, T. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03899.2003 · Cited by 125 · see citing works