The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Regulation of brain function by exercise
Open accessAbstract
The effect of excercise on brain function was investigated through animal experiments. Exercise leads to increased serum calcium levels, and the calcium is transported to the brain. This in turn enhances brain dopamine synthesis through a calmodulin-dependent system, and increased dopamine levels regulate various brain functions. There are abnormally low levels of dopamine in the neostriatum and nucleus accumbens of epileptic mice (El mice strain) and spontaneously hypertensive rats (SHR). The low dopamine levels in those animals were improved following intracerebroventricular administration of calcium chloride. Dopamine levels and blood pressure in SHR were also normalized by exercise. In epileptic El mice, convulsions normalized dopamine levels and physiologic function. These findings suggest that exercise or convulsions affect brain function through calcium/calmodulin-dependent dopamine synthesis. This leads to the possibility that some symptoms of Parkinson's disease or senile dementia might be improved by exercise.
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Folkow, B. (1982) · Physiological Reviews · doi:10.1152/physrev.1982.62.2.347 · Cited by 1,768
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Loss of Dopamine Uptake Sites Labeled with [ 3 H]GBR-12935 in Alzheimer’s Disease
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Cited by
Heyn, P., Abreu, B. C., & Ottenbacher, K. J. (2004) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2004.03.019 · Cited by 1,223
Goodwin, V. A., Richards, S. H., Taylor, R. S., Taylor, A. H., & Campbell, J. L. (2008) · Movement Disorders · doi:10.1002/mds.21922 · Cited by 922
Physical activity and memory functions: An interventional study
Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499
Biological mechanisms underlying the role of physical fitness in health and resilience
Silverman, M. N., & Deuster, P. A. (2014) · Interface Focus · doi:10.1098/rsfs.2014.0040 · Cited by 416
Exercise Benefits Brain Function: The Monoamine Connection
Lin, T.-W., & Kuo, Y.-M. (2013) · Brain Sciences · doi:10.3390/brainsci3010039 · Cited by 392
Metadata
- Authors
- Sutoo, D., & Akiyama, K.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 13
- Issue
- 1
- Pages
- 1-14
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2026675724
- Cited by
- 273
- References
- 3
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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