The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Biological effects of off-pump vs. on-pump coronary artery surgery: focus on inflammation, hemostasis and oxidative stress
Open accessAbstract
Cardiopulmonary bypass (CPB) has been recognized as a cause of complex systemic inflammatory response, which significantly contributes to several adverse postoperative complications. In the last few years, off-pump coronary artery bypass grafting has gained widespread diffusion as an alternative technique to conventional on-pump coronary artery bypass grafting. Surgeons supporting off-pump surgery state that the avoidance of the CPB and myocardial ischemia-reperfusion significantly reduces the postoperative systemic inflammatory response and other biological derangements and, possibly, may improve the clinical outcomes. We review, here, the available evidence concerning possible differences between off-pump and on-pump procedures in terms of inflammation, hemostasis and oxidative stress. Consistent differences in the involvement of these systems are observed, but they are limited to the final steps of the surgical procedures and the early hours after. These findings suggest that the global surgical trauma may be as important, or even more, as the CPB in terms of systemic inflammatory and coagulation-fibrinolytic pathway activation. Further studies are needed in order to confirm this hypothesis.
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“Nonrandomized studies have shown a marked difference in complement activation (C3a, C5a) between on-pump and off-pump CPB patients [7].”
From Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass (2014) · cites this paper as [7]
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Cites
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Raedschelders, K., Ansley, D. M., & Chen, D. D. Y. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.11.004 · Cited by 393
Afilalo, J., Rasti, M., Ohayon, S. M., Shimony, A., & Eisenberg, M. J. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr307 · Cited by 185
Chemokines Are Associated With Delirium After Cardiac Surgery
Rudolph, J. L., Ramlawi, B., Kuchel, G. A., McElhaney, J. E., Xie, D., Sellke, F. W., Khabbaz, K. R., Levkoff, S. E., & Marcantonio, E. R. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.2.184 · Cited by 184
Anastasiadis, K., Antonitsis, P., Haidich, A., Argiriadou, H., Deliopoulos, A., & Papakonstantinou, C. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.01.020 · Cited by 136
Narrative review of the systemic inflammatory reaction to cardiac surgery and cardiopulmonary bypass
Squiccimarro, E., Stasi, A., Lorusso, R., & Paparella, D. (2022) · Artificial Organs · doi:10.1111/aor.14171 · Cited by 126
Metadata
- Authors
- Biglioli, P.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Biglioli, P
- Venue
- European Journal of Cardio-Thoracic Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-08
- Volume
- 24
- Issue
- 2
- Pages
- 260-269
- ISSN
- 1010-7940 (ISSN-L)
- OpenAlex
- W2098507195
- Cited by
- 209
- References
- 66
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 2 · 2017: 7 · 2016: 11 · 2015: 7 · 2014: 11 · 2013: 5 · 2012: 13
- FWCI
- 10.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Cardio-Thoracic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Hematology › Blood transfusion and management
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- off-pump coronary artery bypass, on-pump coronary artery bypass grafting, cardiopulmonary bypass, systemic inflammatory response, hemostasis, oxidative stress, myocardial ischemia-reperfusion injury, postoperative complications, surgical trauma
- MeSH terms
- C-Reactive Protein, Cardiopulmonary Bypass, Complement Activation, Coronary Disease, Fibrinolysis, Heart-Assist Devices, Hemostasis, Humans, Inflammation, Interleukins, Leukocytes, Pancreatic Elastase, Platelet Aggregation, Time Factors, Tumor Necrosis Factor-alpha, Biomarkers, Oxidative Stress
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