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Cited by 285

The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.

Hypoxia and Reoxygenation: a Possible Mechanism for Placental Oxidative Stress in Preeclampsia

Open access
Hung, Tai-Ho, Burton, Graham J.·2006·Taiwanese Journal of Obstetrics and Gynecology
DOI 10.1016/s1028-4559(09)60224-2
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Abstract

Preeclampsia is a human pregnancy-specific disorder that is diagnosed by the new appearance of hypertension and proteinuria after 20 weeks' gestation. It is a leading cause of perinatal morbidity and mortality, and the only intervention that effectively reverses the syndrome is delivery. Oxidative stress of the placenta is considered to be a key intermediary step in the pathogenesis of preeclampsia, but the cause for the stress remains unknown. Hypoxia-reoxygenation (H/R) injury, as a result of intermittent placental perfusion secondary to deficient trophoblast invasion of the endometrial arteries, is a possible mechanism. In this review, we present evidence to show that there is a plausible basis from which to assume that blood flow in the intervillous space will be intermittent in all normal pregnancies. The intermittency will be exacerbated by impaired conversion of the spiral arteries, or by the presence of atherotic changes that reduce their caliber as seen in preeclampsia. Placental oxidative stress can be the consequences of fluctuations in oxygen concentrations after H/R through the actions of reactive oxygen species. On this basis, there will be a complete spectrum of placental changes among the normal, the late onset and the early onset preeclamptic states. Viewing the syndrome as a continuum of H/R insults provides new insight into the pathophysiology of pregnancy that will hope fully lead to improved clinical interventions.

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Metadata

Authors
Hung, T.-H., & Burton, G. J.
Venue
Taiwanese Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2006-09
Volume
45
Issue
3
Pages
189-200
ISSN
1028-4559 (ISSN-L)
DOI
10.1016/s1028-4559(09)60224-2
OpenAlex
W2165954309
Cited by
285
References
109
FWCI
7.31
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Hypoxia and Reoxygenation: a Possible Mechanism for Placental Oxidative Stress in Preeclampsia. https://app.cochat.ai/papers/10.1016/s1028-4559(09)60224-2
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Hung, T.-H., & Burton, G. J. (2006). Hypoxia and Reoxygenation: a Possible Mechanism for Placental Oxidative Stress in Preeclampsia. Taiwanese Journal of Obstetrics and Gynecology. https://doi.org/10.1016/s1028-4559(09)60224-2

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.