Cited by 215Iron Metabolism and DisordersFerroptosis and cancer prognosisErythropoietin and Anemia Treatment

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The iron metabolism of neoplastic cells: alterations that facilitate proliferation?

Kwok, Juliana C, Richardson, Des R.·2002·Critical Reviews in Oncology/Hematology

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Abstract

For many years it has been known that neoplastic cells express high levels of the transferrin receptor 1 (TfR1) and internalize iron (Fe) from transferrin (Tf) at a tremendous rate. Considering the high requirement of neoplastic cells for Fe, understanding its metabolism is vital in terms of devising potential new therapies. Apart from TfR1, a number of molecules have been identified that may have roles in Fe metabolism and cellular proliferation. These molecules include transferrin (Tf), the oestrogen-inducible transferrin receptor-like protein, transferrin receptor 2 (TfR2), melanotransferrin (MTf), ceruloplasmin, and ferritin. In the present review these latter molecules are discussed in terms of their potential functions in tumour cell Fe metabolism and proliferation. Further studies are essential to determine the specific roles of these proteins in the pathogenesis of cancer.

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See all 215

Authors: Kwok, J. C., & Richardson, D. R.
Affiliations: The Heart Research Institute (AU)
Corresponding author: Richardson, Des R.
ORCID: Richardson, Des R.
Venue: Critical Reviews in Oncology/Hematology
Publisher: Elsevier BV
Published: 2002-04
Volume: 42
Issue: 1
Pages: 65-78
ISSN: 1040-8428 (ISSN-L)
DOI: 10.1016/s1040-8428(01)00213-x
OpenAlex: W2049332203
Cited by: 215
References: 162
Citations by year: 2026: 2 · 2025: 1 · 2024: 14 · 2023: 15 · 2022: 5 · 2021: 11 · 2020: 10 · 2019: 8 · 2018: 6 · 2017: 13 · 2016: 9 · 2015: 13 · 2014: 10 · 2013: 18 · 2012: 9
FWCI: 1.04
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Critical Reviews in Oncology/Hematology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Keywords: iron metabolism, neoplastic cells, transferrin receptor 1, transferrin receptor 2, transferrin, melanotransferrin, ceruloplasmin, ferritin, tumor cell proliferation, carcinogenesis, iron transport
MeSH terms: Animals, Antigens, Neoplasm, Biological Transport, Cell Division, Ceruloplasmin, Endocytosis, Estrogens, Ferritins, Humans, Iron, Neoplasm Proteins, Neoplasms, Receptors, Transferrin, Transferrin, Nonheme Iron Proteins, Melanoma-Specific Antigens

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The iron metabolism of neoplastic cells: alterations that facilitate proliferation?

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