The DOI matches its Crossref record; 74 of the 77 references it cites were found in a registry or an index.
Nongenomic Membrane Actions of Glucocorticoids in Vertebrates
Abstract
For decades, it was widely assumed that glucocorticoids (GCs) work solely through changes in gene expression to exert their physiological actions, a process that normally takes several hours to occur. However, recent evidence indicates that GCs might also act at the membrane through specific receptors to exert multiple rapid effects on various tissues and cells. GCs modulate hormone secretion, neuronal excitability, behavior, cell morphology, carbohydrate metabolism and other processes within seconds or minutes. These early actions occur independent of the genome and are transduced by the same biochemical effector pathways responsible for mediating rapid responses to neurotransmitters. The biological significance of most rapid GC effects are not well understood, but many might be related to the important functions that this hormone plays in modulating stress responses.
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“a large number of reported rapid, non-genomic actions of adrenal steroids (Borski, 2000; Makara and Haller, 2001)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Borski, 2000
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Metadata
- Authors
- Borski, R. J.
- Affiliations
- North Carolina State University (US)
- Corresponding author
- Borski, Russell J.
- ORCID
- Borski, Russell J.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 11
- Issue
- 10
- Pages
- 427-436
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2135070639
- Cited by
- 184
- References
- 77
- Citations by year
- 2026: 3 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 10 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 8
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoids, non-genomic steroid action, membrane steroid receptors, stress response, neuronal excitability, behavior, carbohydrate metabolism, hormone secretion, cell morphology
- MeSH terms
- Animals, Glucocorticoids, Humans, Membranes, Vertebrates
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