Cited by 184Estrogen and related hormone effectsReceptor Mechanisms and SignalingAdrenal Hormones and Disorders

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Nongenomic Membrane Actions of Glucocorticoids in Vertebrates

Borski, Russell J.·2000·Trends in Endocrinology & Metabolism

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Abstract

For decades, it was widely assumed that glucocorticoids (GCs) work solely through changes in gene expression to exert their physiological actions, a process that normally takes several hours to occur. However, recent evidence indicates that GCs might also act at the membrane through specific receptors to exert multiple rapid effects on various tissues and cells. GCs modulate hormone secretion, neuronal excitability, behavior, cell morphology, carbohydrate metabolism and other processes within seconds or minutes. These early actions occur independent of the genome and are transduced by the same biochemical effector pathways responsible for mediating rapid responses to neurotransmitters. The biological significance of most rapid GC effects are not well understood, but many might be related to the important functions that this hormone plays in modulating stress responses.

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Authors: Borski, R. J.
Affiliations: North Carolina State University (US)
Corresponding author: Borski, Russell J.
ORCID: Borski, Russell J.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2000-12
Volume: 11
Issue: 10
Pages: 427-436
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/s1043-2760(00)00325-8
OpenAlex: W2135070639
Cited by: 184
References: 77
Citations by year: 2026: 3 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 10 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 8
FWCI: 1.47
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: glucocorticoids, non-genomic steroid action, membrane steroid receptors, stress response, neuronal excitability, behavior, carbohydrate metabolism, hormone secretion, cell morphology
MeSH terms: Animals, Glucocorticoids, Humans, Membranes, Vertebrates

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Nongenomic Membrane Actions of Glucocorticoids in Vertebrates

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