Cited by 524Estrogen and related hormone effectsNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

A corticosteroid receptor in neuronal membranes

Orchinik, Miles, Murray, Thomas F., Moore, Frank L.·1991·Science

Abstract

Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [3H]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [3H]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.

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Crossref · 10.1126/science.2063198

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36 of 36 references verified0 citation errors · 0 not checkable

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Authors
Orchinik, M., Murray, T. F., & Moore, F. L.
Affiliations
Oregon State University (US)
Venue
Science
Published
1991-06-28
Volume
252
Issue
5014
Pages
1848-1851
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2061928804
Cited by
523
References
36
Citations by year
2026: 3 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 19 · 2013: 20 · 2012: 20
FWCI
13.05
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
corticosteroid receptors, cell surface receptors, corticosterone binding, synaptic membranes, neuronal membrane, amphibian brain, male reproductive behavior, behavioral regulation, steroid binding affinity
MeSH terms
Amphibians, Animals, Autoradiography, Binding, Competitive, Brain, Cell Fractionation, Cell Membrane, Corticosterone, Kinetics, Male, Neurons, Receptors, Glucocorticoid, Sexual Behavior, Animal, Synaptosomes, Tritium

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