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Mechanistic investigation of ionization suppression in electrospray ionization
Abstract
We show results from experiments designed to determine the relative importance of gas phase processes and solution phase processes into ionization suppression observed in biological sample extracts. The data indicate that gas phase reactions leading to the loss of net charge on the analyte is not likely to be the most important process involved in ionization suppression. The results point to changes in the droplet solution properties caused by the presence of nonvolatile solutes as the main cause of ionization suppression in electrospray ionization of biological extracts.
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Citations
Cited by
Taylor, P. J. (2005) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2004.11.007 · Cited by 1,248
Dams, R., Huestis, M. A., Lambert, W. E., & Murphy, C. M. (2003) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(03)00574-9 · Cited by 600
Carr, S. A., Abbatiello, S. E., Ackermann, B. L., Borchers, C., Domon, B., Deutsch, E. W., Grant, R. P., Hoofnagle, A. N., Hüttenhain, R., Koomen, J. M., et al. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.036095 · Cited by 561
Hebert, A. S., Richards, A. L., Bailey, D. J., Ulbrich, A., Coughlin, E. E., Westphall, M. S., & Coon, J. J. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.034769 · Cited by 528
Ion suppression; A critical review on causes, evaluation, prevention and applications
Furey, A., Moriarty, M., Bane, V., Kinsella, B., & Lehane, M. (2013) · Talanta · doi:10.1016/j.talanta.2013.03.048 · Cited by 521
Metadata
- Authors
- King, R., Bonfiglio, R., Fernandez-Metzler, C., Miller-Stein, C., & Olah, T.
- Venue
- Journal of the American Society for Mass Spectrometry
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-11-01
- Volume
- 11
- Issue
- 11
- Pages
- 942-950
- ISSN
- 1044-0305 (ISSN-L)
- OpenAlex
- W2041575674
- Cited by
- 1,086
- References
- 0
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- King, R., Bonfiglio, R., Fernandez-Metzler, C., Miller-Stein, C., & Olah, T. (2000). Mechanistic investigation of ionization suppression in electrospray ionization. Journal of the American Society for Mass Spectrometry. https://doi.org/10.1016/s1044-0305(00)00163-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
