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Cited by 69Maternal Mental Health During Pregnancy and PostpartumReproductive System and PregnancyPregnancy and Medication Impact

Does stress influence early pregnancy loss?

Nelson, D·2003·Annals of Epidemiology
DOI 10.1016/s1047-2797(02)00419-2
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Abstract

Purpose The purpose of this study is to examine the relationship between stress, cortisol level and the risk for spontaneous abortion and determine the influence of stress on health-related behaviors.Methods Three hundred and twenty-six pregnant women presenting to the emergency department at the Hospital of the University of Pennsylvania from March 1999 through March 2000 were recruited and followed through 22 weeks gestation. Cases were women who experienced a spontaneous abortion and controls were women who maintained their pregnancy. Stress was measured by the Perceived Stress Scale (PSS), the Prenatal Social Environment Inventory (PSEI) and the Index of Spousal Abuse (ISA) prior to confirmation of spontaneous abortion. Blood samples were collected to measure cortisol and sex hormone levels. Urine samples were collected to assess cotinine, cocaine and marijuana use.Results No relationship was found between psychosocial stress, as determined by the three stress scales or cortisol level, and the risk for spontaneous abortion. Women with high stress, as measured by the PSEI, were more likely to use cigarettes and marijuana during pregnancy. High psychosocial stress during early pregnancy was not related to spontaneous abortion but high stress was associated with substance use during pregnancy.Conclusion The influence of psychosocial stress on the risk of spontaneous abortion is unclear.

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Crossref · 10.1016/s1047-2797(02)00419-2

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25 of 25 references verified0 citation errors · 0 not checkable

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  • Alcohol use is an important modifiable risk factor for miscarriage.

    “Our literature review found that alcohol use is also an important modifiable risk factor, as high alcohol consumption during the first trimester is associated with an increase in miscarriage risk (aOR 1·67; 95% CI 1·31-2·19; Table 6). 25,39,62-70”

    From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [63]

  • High alcohol consumption during the first trimester is associated with an increase in miscarriage risk (aOR 1.67; 95% CI 1.31-2.19).

    “Our literature review found that alcohol use is also an important modifiable risk factor, as high alcohol consumption during the first trimester is associated with an increase in miscarriage risk (aOR 1·67; 95% CI 1·31-2·19; Table 6). 25,39,62-70”

    From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [63]

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Authors
Nelson, D.
Affiliations
University of Pennsylvania (US)
Corresponding author
Nelson, D
ORCID
Nelson, D
Venue
Annals of Epidemiology
Publisher
Elsevier BV
Published
2003-04
Volume
13
Issue
4
Pages
223-229
ISSN
1047-2797 (ISSN-L)
DOI
10.1016/s1047-2797(02)00419-2
OpenAlex
W2156836608
Cited by
69
References
25
Citations by year
2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 5
FWCI
3.04
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Annals of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD36918-04, R01HD036918)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
psychosocial stress, miscarriage, early pregnancy loss, cortisol, prenatal stress, substance use during pregnancy, smoking during pregnancy, marijuana use during pregnancy, cocaine use during pregnancy, marital violence, sex hormones
MeSH terms
Abortion, Spontaneous, Adolescent, Adult, Black or African American, Female, Humans, Marijuana Smoking, Pregnancy, Risk Factors, Smoking, Stress, Psychological, Urban Population, Health Behavior, Logistic Models

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