Prenatal stress and risk of spontaneous abortion
Abstract
OBJECTIVE: The aim of this study was to evaluate the association between exposure to life-threatening rocket attacks and spontaneous abortions (SAs). STUDY DESIGN: This is a historical cohort study comparing 1345 pregnancies of female residents of a town exposed to rocket attacks with 2143 pregnancies of female residents of an unexposed town. Demographic and medical data were obtained from hospital records and exposure information from official local databases. Intensity of exposure was calculated for preconception and pregnancy periods. RESULTS: Compared with unexposed group, women in the exposed group had higher rates of SA (6.9% versus 4.7%, adjusted odds ratio = 1.59, 95% confidence interval = 1.17-2.2, p = .003). Intensity of preconception and pregnancy exposure were nonlinearly associated with SA risk; both the highest and the lowest quintiles of exposure were associated with increased risk of SA. CONCLUSIONS: Stress during preconception and pregnancy was associated with increased risk of SA.
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Alcohol use is an important modifiable risk factor for miscarriage.
“Our literature review found that alcohol use is also an important modifiable risk factor, as high alcohol consumption during the first trimester is associated with an increase in miscarriage risk (aOR 1·67; 95% CI 1·31-2·19; Table 6). 25,39,62-70”
From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [64]
High alcohol consumption during the first trimester is associated with an increase in miscarriage risk (aOR 1.67; 95% CI 1.31-2.19).
“Our literature review found that alcohol use is also an important modifiable risk factor, as high alcohol consumption during the first trimester is associated with an increase in miscarriage risk (aOR 1·67; 95% CI 1·31-2·19; Table 6). 25,39,62-70”
From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [64]
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- Authors
- Wainstock, T., Lerner-Geva, L., Glasser, S., Shoham-Vardi, I., & Anteby, E. Y.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Corresponding author
- Wainstock, Tamar
- Venue
- Psychosomatic Medicine
- Published
- 2013-04
- Volume
- 75
- Issue
- 3
- Pages
- 228-235
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W1996706569
- Cited by
- 54
- References
- 57
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 4 · 2013: 1
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- prenatal stress, miscarriage, rocket attacks, war exposure, preconception exposure, exposure intensity, nonlinear dose-response relationship, maternal stress
- MeSH terms
- Abortion, Spontaneous, Adult, Female, Humans, Israel, Pregnancy, Risk, Risk Factors, Stress, Psychological, Cohort Studies, Odds Ratio, Young Adult
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