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Cited by 87Smoking Behavior and CessationPrenatal Substance Exposure EffectsPregnancy and Medication Impact

Paternal and Maternal Smoking Habits before Conception and During the First Trimester

Chatenoud, Liliane, Parazzini, Fabio, Di Cintio, Elisabetta, Zanconato, Giovanni, Benzi, Guido, Bortolus, Renata, La Vecchia, Carlo·1998·Annals of Epidemiology
DOI 10.1016/s1047-2797(98)00017-9
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Abstract

Purpose This study examined the association between maternal smoking before and during the first trimester of pregnancy and spontaneous abortion.Methods We have been conducting a hospital-based case-control study on risk factors for spontaneous abortion in the greater Milan area. We collected information from 782 cases of spontaneous abortions and 1543 controls (women who delivered at term healthy infants).Results With respect to never smokers, the odds ratio (OR) were 0.7 (95%, confidence interval (CI), 0.5-1.0) for women who quit smoking and 1.3 (95% CI, 1.0-1.6) for those who continued during pregnancy. Women who smoked more than 10 cigarettes/day in the first trimester were at increased risk of miscarriage, with an OR of 1.4 (95% CI, 1.0-2.1). No relationship was evident between the number of cigarettes smoked before conception and the risk of abortion. Likewise, no association emerged between paternal smoking and miscarriage. Moreover, no significant interaction or modification effect was obtained when strata of age and other major characteristics were investigated.Conclusions The risk of abortion associated with cigarette smoking during the first trimester of pregnancy was measurable and noticeable in this population, and accounted for 9% (95% CI, 6-13%) of all cases. The increased risk of spontaneous abortion in women smoking during pregnancy is a further reason to encourage pregnant women to quit.

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  • A defect in decidualization can result from changes in immune cells, foremost uterine natural killer cells, or endometrial stem cells, which may result in endometrial breakdown and miscarriage.

    “A defect in decidualization can result from changes in immune cells, 52 foremost uterine natural killer cells, 53 or endometrial stem cells, 54,55 which may result in endometrial breakdown and miscarriage.”

    From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [53]

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Authors
Chatenoud, L., Parazzini, F., Di Cintio, E., Zanconato, G., Benzi, G., Bortolus, R., & La Vecchia, C.
Affiliations
  • Mario Negri Institute for Pharmacological Research (IT)
  • University of Milan (IT)
  • University of Verona (IT)
Corresponding author
Chatenoud, Liliane
ORCID
Venue
Annals of Epidemiology
Publisher
Elsevier BV
Published
1998-11
Volume
8
Issue
8
Pages
520-526
ISSN
1047-2797 (ISSN-L)
DOI
10.1016/s1047-2797(98)00017-9
OpenAlex
W1998436806
Cited by
87
References
34
Citations by year
2025: 1 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 10 · 2013: 3 · 2012: 4
FWCI
1.84
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Annals of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
smoking during pregnancy, first trimester, paternal smoking, maternal smoking, miscarriage, cigarette consumption, smoking cessation, risk factors
MeSH terms
Abortion, Spontaneous, Adult, Fathers, Female, Humans, Italy, Male, Pregnancy, Pregnancy Trimester, First, Prenatal Exposure Delayed Effects, Risk Factors, Smoking, Tobacco Smoke Pollution, Confounding Factors, Epidemiologic, Odds Ratio, Case-Control Studies

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