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Intracellular Assembly of VLDL

Olofsson, Sven-Olof, Stillemark-Billton, Pia, Asp, Lennart·2000·Trends in Cardiovascular Medicine
DOI 10.1016/s1050-1738(01)00071-8
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Abstract

The assembly of very low-density lipoproteins (VLDL) occurs in two major steps. The first step is the co-and post-translational lipidation of apoB, forming pre-VLDL in the rough endoplasmic reticulum. The microsomal triglyceride transfer protein catalyzes this step. In the second step pre-VLDL is converted to bona fide VLDL in a smooth membrane compartment. This step depends on ADP-ribosylation factor 1 and its activation of phospholipase D.

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Metadata

Authors
Olofsson, S.-O., Stillemark-Billton, P., & Asp, L.
Venue
Trends in Cardiovascular Medicine
Publisher
Elsevier BV
Published
2000-11
Volume
10
Issue
8
Pages
338-345
ISSN
1050-1738
DOI
10.1016/s1050-1738(01)00071-8
Cited by
132
References
1
Language
en
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