Cited by 418Lipid metabolism and disordersLiver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance

Open access
Choi, Sung Hee, Ginsberg, Henry N·2011·Trends in Endocrinology & Metabolism

Abstract

Insulin resistance (IR) affects not only the regulation of carbohydrate metabolism but all aspects of lipid and lipoprotein metabolism. IR is associated with increased secretion of VLDL and increased plasma triglycerides, as well as with hepatic steatosis, despite the increased VLDL secretion. Here we link IR with increased VLDL secretion and hepatic steatosis at both the physiologic and molecular levels. Increased VLDL secretion, together with the downstream effects on high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) size, is proatherogenic. Hepatic steatosis is a risk factor for steatohepatitis and cirrhosis. Understanding the complex inter-relationships between IR and these abnormalities of liver lipid homeostasis will provide insights relevant to new therapies for these increasing clinical problems.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.tem.2011.04.007

Cites

171 of 171 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [108]Melish J Le N-A Ginsberg H Steinberg D Brown WV Dissociation of triglyceride and apoprotein-B production in very low density lipoproteins Am J Physiol 1980 239 E354 E362 7435612

Cited by

Sorted by citations

Authors
Choi, S. H., & Ginsberg, H. N.
Affiliations
  • Seoul National University (KR)
  • Columbia University (US)
Corresponding author
Ginsberg, Henry N
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2011-09
Volume
22
Issue
9
Pages
353-363
ISSN
1043-2760 (ISSN-L)
OpenAlex
W2011523747
Cited by
418
References
171
Citations by year
2026: 33 · 2025: 25 · 2024: 26 · 2023: 26 · 2022: 28 · 2021: 31 · 2020: 41 · 2019: 28 · 2018: 26 · 2017: 29 · 2016: 22 · 2015: 30 · 2014: 24 · 2013: 29 · 2012: 16
FWCI
3.93
Type
journal article
Language
en
Open access
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL073030, R01HL055638)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
insulin resistance, very low density lipoprotein secretion, hepatic steatosis, plasma triglycerides, HDL cholesterol, LDL particle size, atherogenesis, steatohepatitis, liver cirrhosis
MeSH terms
Fatty Liver, Humans, Insulin Resistance, Lipoproteins, VLDL

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review