Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance
Open accessAbstract
Insulin resistance (IR) affects not only the regulation of carbohydrate metabolism but all aspects of lipid and lipoprotein metabolism. IR is associated with increased secretion of VLDL and increased plasma triglycerides, as well as with hepatic steatosis, despite the increased VLDL secretion. Here we link IR with increased VLDL secretion and hepatic steatosis at both the physiologic and molecular levels. Increased VLDL secretion, together with the downstream effects on high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) size, is proatherogenic. Hepatic steatosis is a risk factor for steatohepatitis and cirrhosis. Understanding the complex inter-relationships between IR and these abnormalities of liver lipid homeostasis will provide insights relevant to new therapies for these increasing clinical problems.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Once hepatic fat content exceeds a certain level (e.g., intrahepatic TG >10%), VLDL secretion reaches a plateau.
“The IR-induced increase in VLDL-TG secretion may help to alleviate lipid overload; however, once hepatic fat content exceeds a certain level (e.g., intrahepatic TG >10%), VLDL secretion reaches a plateau [111-113].”
From Hepatic Insulin Resistance and Steatosis in Metabolic Dysfunction-Associated Steatotic Liver Disease: New Insights into Mechanisms and Clinical Implications (2025) · cites this paper as [112]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Haffner, S. M., Lehto, S., Rönnemaa, T., Pyörälä, K., & Laakso, M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807233390404 · Cited by 7,000 · see citing works
Signal integration in the endoplasmic reticulum unfolded protein response
Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,308 · see citing works
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,285 · see citing works
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975 · see citing works
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604 · see citing works
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., & Hobbs, H. H. (2008) · Nature Genetics · doi:10.1038/ng.257 · Cited by 3,416 · see citing works
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802 · see citing works
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082 · see citing works
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · see citing works
ER stress and the unfolded protein response
Schröder, M., & Kaufman, R. J. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.06.056 · Cited by 1,750 · see citing works
Role of LXRs in control of lipogenesisPreprint
Schultz, J. R., Tu, H., Luk, A. Y., Repa, J. J., Medina, J. C., Li, L., Schwendner, S. W., Wang, S., Thoolen, M., Mangelsdorf, D. J., et al. (2000) · Genes & Development · doi:10.1101/gad.850400 · Cited by 1,673 · see citing works
Postic, C., & Girard, J. R. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34275 · Cited by 1,200 · see citing works
Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1
Lee, A., Scapa, E. F., Cohen, D. E., & Glimcher, L. H. (2008) · Science · doi:10.1126/science.1158042 · Cited by 978 · see citing works
Selective versus Total Insulin Resistance: A Pathogenic Paradox
Brown, M. S., & Goldstein, J. L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.12.009 · Cited by 959 · see citing works
Splanchnic lipolysis in human obesity
Nielsen, S., Guo, Z., Johnson, C. M., Hensrud, D. D., & Jensen, M. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21047 · Cited by 933 · see citing works
Cholesteryl Ester Transfer Protein
Barter, P. J., Brewer, H. B., Chapman, M. J., Hennekens, C. H., Rader, D. J., & Tall, A. R. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000054658.91146.64 · Cited by 868 · see citing works
Etiology of Insulin Resistance
Petersen, K. F., & Shulman, G. I. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.01.009 · Cited by 825 · cited 1× · see citing works
“IR, a major abnormality underlying type 2 diabetes mellitus, is defined as the pathophysiological condition of reduced insulin responsiveness in liver, muscle, and adipose tissue (1;2).”
BackgroundAdiels, M., Olofsson, S.-O., Taskinen, M.-R., & Borén, J. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.160192 · Cited by 820 · see citing works
Iizuka, K., Bruick, R. K., Liang, G., Horton, J. D., & Uyeda, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401516101 · Cited by 786 · see citing works
Joseph, S. B., Laffitte, B. A., Patel, P. H., Watson, M. A., Matsukuma, K. E., Walczak, R., Collins, J. L., Osborne, T. F., & Tontonoz, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111041200 · Cited by 779 · see citing works
Li, S., Brown, M. S., & Goldstein, J. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914798107 · Cited by 733 · cited 1× · see citing works
“This could be the pathway for the selective insulinstimulated induction of SREBP-1c expression in an otherwise insulin resistant liver (61;62).”
BackgroundWerstuck, G. H., Lentz, S. R., Dayal, S., Hossain, G. S., Sood, S. K., Shi, Y., Zhou, J., Maeda, N., Krisans, S. K., Malinow, M. R., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11596 · Cited by 702 · see citing works
Shimano, H., Yahagi, N., Amemiya-Kudo, M., Hasty, A. H., Osuga, J.-I., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Harada, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35832 · Cited by 691 · see citing works
Overproduction of large VLDL particles is driven by increased liver fat content in man
Adiels, M., Taskinen, M.-R., Packard, C., Caslake, M. J., Soro-Paavonen, A., Westerbacka, J., Vehkavaara, S., Häkkinen, A., Olofsson, S.-O., Yki-Järvinen, H., et al. (2006) · Diabetologia · doi:10.1007/s00125-005-0125-z · Cited by 690 · see citing works
Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111421200 · Cited by 669 · see citing works
Matsusue, K., Haluzı́k, M., Lambert, G. C., Yim, S.-H., Gavrilova, O., Ward, J. M., Brewer, B., Reitman, M. L., & Gonzalez, F. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317223 · Cited by 636 · see citing works
Fabbrini, E., Mohammed, B. S., Magkos, F., Korenblat, K. M., Patterson, B. W., & Klein, S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.038 · Cited by 631 · see citing works
Yu, S., Matsusue, K., Kashireddy, P. V., Cao, W.-Q., Yeldandi, V., Yeldandi, A. V., Rao, M. S., Gonzalez, F. J., & Reddy, J. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m210062200 · Cited by 621 · see citing works
He, S., McPhaul, C., Li, J. Z., Garuti, R., Kinch, L. N., Grishin, N. V., Cohen, J. C., & Hobbs, H. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064501 · Cited by 604 · see citing works
Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly
Hussain, M. M., Shi, J., & Dreizen, P. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r200014-jlr200 · Cited by 591 · see citing works
Rutkowski, D. T., Wu, J., Back, S.-H., Callaghan, M. U., Ferris, S. P., Iqbal, J., Clark, R. L., Miao, H. Z., Hassler, J. R., Fornek, J. L., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.10.015 · Cited by 580 · see citing works
Chen, G., Liang, G., Ou, J., Goldstein, J. L., & Brown, M. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404297101 · Cited by 546 · see citing works
Lewis, G., Uffelman, K., Szeto, L., Weller, B., & Steiner, G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117633 · Cited by 533 · see citing works
Uyeda, K., & Repa, J. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.008 · Cited by 531 · see citing works
Regulation of Plasma Triglycerides in Insulin Resistance and Diabetes
Ginsberg, H. N., Zhang, Y.-L., & Hernandez-Ono, A. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.01.005 · Cited by 531 · see citing works
Self-citationHuang, W., Metlakunta, A., Dedousis, N., Zhang, P., Sipula, I., Dube, J. J., Scott, D. K., & O'Doherty, R. M. (2010) · Diabetes · doi:10.2337/db09-0016 · Cited by 520 · see citing works
FoxO1 Regulates Multiple Metabolic Pathways in the Liver
Zhang, W., Patil, S., Chauhan, B., Guo, S., Powell, D. R., Le, J., Klotsas, A., Matika, R. W., Xiao, X., Franks, R. R., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600272200 · Cited by 517 · see citing works
Grefhorst, A., Elzinga, B. M., Voshol, P. J., Plösch, T., Kok, T., Bloks, V. W., van der Sluijs, F. H., Havekes, L. M., Romijn, J. A., Verkade, H. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204887200 · Cited by 502 · see citing works
Hepatic uptake of chylomicron remnants
Cooper, A. D. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34932-4 · Cited by 499 · see citing works
Brunzell, J. D., Hazzard, W. R., Porte, D., & Bierman, E. L. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107334 · Cited by 484 · see citing works
Walther, T. C., & Farese, R. V. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.10.009 · Cited by 478 · see citing works
The Liver X Receptor (LXR) and Hepatic Lipogenesis
Cha, J.-Y., & Repa, J. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605023200 · Cited by 474 · see citing works
Biddinger, S. B., Hernandez-Ono, A., Rask-Madsen, C., Haas, J. T., Alemán, J. O., Suzuki, R., Scapa, E. F., Agarwal, C., Carey, M. C., Stephanopoulos, G., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.013 · Cited by 469 · see citing works
Self-citationFisher, E. A. A., & Ginsberg, H. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100068200 · Cited by 459 · see citing works
Self-citationKimmel, A. R., Brasaemle, D., McAndrews-Hill, M., Sztalryd, C., & Londos, C. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r000034 · Cited by 454 · see citing works
Miquilena-Colina, M. E., Lima‐Cabello, E., Sánchez‐Campos, S., García‐Mediavilla, M. V., Fernández‐Bermejo, M., Lozano-Rodríguez, T., Vargas‐Castrillón, J., Buqué, X., Ochoa, B., Aspichueta, P., et al. (2011) · Gut · doi:10.1136/gut.2010.222844 · Cited by 452 · see citing works
Stiles, B., Wang, Y., Stahl, A., Bassilian, S., Lee, W. P., Kim, Y.-J., Sherwin, R., Devaskar, S., Lesche, R., Magnuson, M. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308617100 · Cited by 436 · see citing works
Diraison, F., Moulin, P., & Beylot, M. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70061-7 · Cited by 435 · see citing works
Oyadomari, S., Harding, H. P., Zhang, Y., Oyadomari, M., & Ron, D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.011 · Cited by 431 · see citing works
Matsumoto, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27047 · Cited by 430 · see citing works
Raabe, M., Véniant, M. M., Sullivan, M. A., Zlot, C. H., Björkegren, J., Nielsen, L. B., Wong, J. S., Hamilton, R. L., & Young, S. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6576 · Cited by 424 · see citing works
Cellular fatty acid uptake: a pathway under construction
Su, X., & Abumrad, N. A. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.11.001 · Cited by 410 · see citing works
Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation*
Gerin, I., Clerbaux, L.-A., Haumont, O., Lanthier, N., Das, A. K., Burant, C. F., Leclercq, I. A., MacDougald, O. A., & Bommer, G. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152090 · Cited by 382 · cited 1× · see citing works
“In contrast, miR-33, which is transcribed from an SREBP2 intron, inhibits transcription of several genes involved in FA oxidation as well as the gene for cholesterol transporter, ABCA1 (66).”
BackgroundOta, T., Gayet, C., & Ginsberg, H. N. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32752 · Cited by 376 · see citing works
Self-citationPPARγ2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes
Schadinger, S. E., Bucher, N. L. R., Schreiber, B. M., & Farmer, S. R. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00513.2004 · Cited by 376 · see citing works
Speliotes, E. K., Butler, J. L., Palmer, C. D., Voight, B. F., & Hirschhorn, J. N. (2010) · Hepatology · doi:10.1002/hep.23768 · Cited by 362 · see citing works
Subcellular localization of B apoprotein of plasma lipoproteins in rat liver.
Alexander, C. A., Hamilton, R. L., & Havel, R. J. (1976) · The Journal of Cell Biology · doi:10.1083/jcb.69.2.241 · Cited by 361 · see citing works
Ong, K. T., Mashek, M. T., Bu, S. Y., Greenberg, A. S., & Mashek, D. G. (2010) · Hepatology · doi:10.1002/hep.24006 · Cited by 339 · see citing works
Apolipoprotein synthesis in nonalcoholic steatohepatitis
Charlton, M., Raghavakaimal, S., Rasmussen, D. L., Lindor, K. D., & Nair, S. K. (2002) · Hepatology · doi:10.1053/jhep.2002.32527 · Cited by 332 · see citing works
Lewis, G. F., Uffelman, K. D., Szeto, L., & Steiner, G. A. (1993) · Diabetes · doi:10.2337/diab.42.6.833 · Cited by 323 · see citing works
Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM.
Malmström, R., Packard, C. J., Caslake, M., Bedford, D., Stewart, P., Yki-Järvinen, H., Shepherd, J., & Taskinen, M.-R. (1997) · Diabetologia · doi:10.1007/s001250050700 · Cited by 319 · see citing works
Obstfeld, A. E., Sugaru, E., Thearle, M. S., Francisco, A.-M., Gayet, C., Ginsberg, H. N., Ables, E. V., & Ferrante, A. W. (2010) · Diabetes · doi:10.2337/db09-1403 · Cited by 314 · see citing works
Self-citationReid, B. N., Ables, G. P., Otlivanchik, O., Schoiswohl, G., Zechner, R., Blaner, W. S., Goldberg, I. J., Schwabe, R. F., Chua, S. C., & Huang, L.-S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800533200 · Cited by 307 · see citing works
MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1α and affects lipid metabolism
Iliopoulos, D., Drosatos, K., Hiyama, Y., Goldberg, I. J., & Zannis, V. I. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m004812 · Cited by 300 · see citing works
Juárez, R. G. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26991 · Cited by 298 · see citing works
Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians
Stickel, F., Buch, S., Lau, K., zu Schwabedissen, H. E. M., Berg, T., Ridinger, M., Rietschel, M., Schafmayer, C., Braun, F., Hinrichsen, H. M., et al. (2010) · Hepatology · doi:10.1002/hep.24017 · Cited by 291 · see citing works
Fisher, E. A. A., Zhou, M., Mitchell, D. M., Wu, X., Ōmura, S., Wang, H., Goldberg, A. L., & Ginsberg, H. N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20427 · Cited by 287 · see citing works
Self-citationTaniguchi, C. M., Kondo, T., Sajan, M. P., Luo, J., Bronson, R. T., Asano, T., Farese, R. V., Cantley, L. C., & Kahn, C. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.005 · Cited by 282 · see citing works
FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice
Kamagaté, A., Qu, S., Perdomo, G., Su, D., Kim, D. H., Slusher, S., Meseck, M. L., & Dong, H. H. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32914 · Cited by 281 · see citing works
Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance
Leavens, K. F., Easton, R., Shulman, G. I., Previs, S. F., & Birnbaum, M. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.004 · Cited by 278 · see citing works
Lipid droplets as dynamic organelles connecting storage and efflux of lipids
Olofsson, S., Boström, P., Andersson, L. K., Rutberg, M., Perman, J., & Borén, J. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.08.001 · Cited by 264 · see citing works
Sriburi, R., Bommiasamy, H., Buldak, G. L., Robbins, G. R., Frank, M. W., Jackowski, S., & Brewer, J. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609490200 · Cited by 262 · see citing works
Evolutionarily conserved gene family important for fat storage
Kadereit, B., Kumar, P., Wang, W.-J., Miranda, D., Snapp, E. L., Severina, N., Torregroza, I., Evans, T., & Silver, D. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708579105 · Cited by 252 · see citing works
F ATTY A CID T RANSPORT A CROSS M EMBRANES : Relevance to Nutrition and Metabolic Pathology
Hajri, T., & Abumrad, N. A. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.020402.130846 · Cited by 247 · see citing works
Chen, W., Chang, B. H., Li, L., & Chan, L. (2010) · Hepatology · doi:10.1002/hep.23812 · Cited by 246 · see citing works
Chahil, T. J., & Ginsberg, H. N. (2006) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.06.002 · Cited by 233 · see citing works
Self-citationIrs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
Dong, X. C., Park, S., Lin, X., Copps, K. D., Yi, X., & White, M. F. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25735 · Cited by 230 · see citing works
Insulin regulation of triacylglycerol-rich lipoprotein synthesis and secretion
Sparks, J. D., & Sparks, C. E. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)90088-4 · Cited by 217 · see citing works
Hegarty, B. D., Bobard, A., Hainault, I., Ferré, P., Bossard, P., & Foufelle, F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405067102 · Cited by 208 · see citing works
The case of visceral fat: argument for the defense
Klein, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422028 · Cited by 206 · see citing works
Nagashima, K., Lopez, C., Donovan, D., Ngai, C., Fontanez, N., Bensadoun, A., Fruchart-Najib, J., Holleran, S., Cohn, J. S., Ramakrishnan, R., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200523219 · Cited by 201 · see citing works
Self-citationCabezas, M. C., de Bruin, T. W. A., de Valk, H. W., Shoulders, C. C., Jansen, H., & Erkelens, D. W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116544 · Cited by 200 · see citing works
Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects.
Malmström, R., Packard, C. J., CASLAKE, M. J., Bedford, D. K., Stewart, P., Yki‐Järvinen, H., Shepherd, J., & Taskinen, M. (1998) · Diabetes · doi:10.2337/diabetes.47.5.779 · Cited by 197 · see citing works
Lin, M., Gordon, D., & Wetterau, J. R. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39865-5 · Cited by 196 · see citing works
Horton, J. D., Shimano, H., Hamilton, R. L., Brown, M. S., & Goldstein, J. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6246 · Cited by 190 · see citing works
The Triple Threat to Nascent Apolipoprotein B
Fisher, E. A. A., Pan, M., Chen, X., Wu, X., Wang, H., Jamil, H., Sparks, J. D., & Williams, K. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008885200 · Cited by 189 · see citing works
Duez, H., Lamarche, B., Uffelman, K. D., Valéro, R., Cohn, J. S., & Lewis, G. F. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000222015.76038.14 · Cited by 188 · see citing works
The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism
Ginsberg, H. N., & Fisher, E. A. A. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800090-jlr200 · Cited by 184 · see citing works
Self-citationMatsumoto, M., Ogawa, W., Akimoto, K., Inoue, H., Miyake, K., Furukawa, K., Hayashi, Y., Iguchi, H., Matsuki, Y., Hiramatsu, R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18816 · Cited by 176 · see citing works
Iozzo, P., Bucci, M., Roivainen, A., Någren, K., Järvisalo, M. J., Kišš, J., Guiducci, L., Fielding, B. A., Naum, A. S., Borra, R., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.039 · Cited by 175 · see citing works
Segrest, J. P., Jones, M. K., Mishra, V., Anantharamaiah, G. M., & Garber, D. W. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.10.1674 · Cited by 174 · see citing works
Cohn, J. S., Patterson, B. W., Uffelman, K. D., Davignon, J., & Steiner, G. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032056 · Cited by 170 · see citing works
Ono, H., Shimano, H., Katagiri, H., Yahagi, N., Sakoda, H., Onishi, Y., Anai, M., Ogihara, T., Fujishiro, M., Viana, A. Y. I., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2905 · Cited by 170 · see citing works
Insulin regulation of regional free fatty acid metabolism.
Meek, S., Nair, K. S., & Jensen, M. D. (1999) · Diabetes · doi:10.2337/diabetes.48.1.10 · Cited by 170 · see citing works
Sundaram, M., Zhong, S., Khalil, M. B., Links, P. H., Zhao, Y., Iqbal, J., Hussain, M. M., Parks, R. J., Wang, Y., & Yao, Z. (2009) · Journal of Lipid Research · doi:10.1194/m900346-jlr200 · Cited by 170 · see citing works
CIDE proteins and metabolic disorders
Gong, J., Sun, Z., & Li, P. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328328d0bb · Cited by 167 · see citing works
Wolfrum, C., & Stoffel, M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.001 · Cited by 165 · see citing works
Regulated Co-translational Ubiquitination of Apolipoprotein B100
Zhou, M., Fisher, E. A. A., & Ginsberg, H. N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24649 · Cited by 158 · see citing works
Self-citationHaemmerle, G., Zimmermann, R., Bogner‐Strauß, J. G., Kratky, D., Riederer, M., Knipping, G., & Zechner, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108640200 · Cited by 156 · see citing works
Dashti, N., Williams, D. L., & Alaupovic, P. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38268-7 · Cited by 154 · see citing works
Burkhardt, R., Toh, S. A., Lagor, W. R., Birkeland, A. C., Levin, M. G., Li, X., Robblee, M. M., Fedorov, V. D., Yamamoto, M., Satoh, T., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44213 · Cited by 152 · see citing works
Matsumoto, M., Ogawa, W., Akimoto, K., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318816 · Cited by 152 · see citing works
Magnusson, B., Asp, L., Boström, P., Ruiz, M., Stillemark-Billton, P., Lindén, D., Borén, J., & Olofsson, S. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000223345.11820.da · Cited by 152 · see citing works
Guo, S., Copps, K. D., Dong, X. C., Park, S., Cheng, Z., Pocai, A., Rossetti, L., Sajan, M. P., Farese, R. V., & White, M. F. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00138-09 · Cited by 152 · see citing works
microRNAs and cholesterol metabolism
Moore, K. J., Rayner, K. J., Suárez, Y., & Fernandez-Hernando, C. F. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.008 · Cited by 151 · see citing works
Intracellular Assembly of VLDL
Olofsson, S., Stillemark-Billton, P., & Asp, L. (2000) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00071-8 · Cited by 145 · see citing works
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis
Laplante, M., & Sabatini, D. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000323107 · Cited by 145 · see citing works
Why Syndrome X? From Harold Himsworth to the Insulin Resistance Syndrome
Reaven, G. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.001 · Cited by 142 · see citing works
Fatty Acid Transport: The Diffusion Mechanism in Model and Biological Membranes
Hamilton, J. A., Johnson, R. A., Corkey, B. E., & Kamp, F. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:99 · Cited by 142 · see citing works
Dubuquoy, C., Robichon, C., Lasnier, F., Langlois, C., Dugail, I., Foufelle, F., Girard, J. R., Burnol, A., Postic, C., & Moldes, M. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.10.024 · Cited by 139 · see citing works
Matsumoto, M., Ogawa, W., Teshigawara, K., Inoue, H., Miyake, K., Sakaue, H., & Kasuga, M. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1672 · Cited by 138 · see citing works
Intestinal lipoprotein overproduction in insulin-resistant states
Adeli, K., & Lewis, G. F. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282ffaf82 · Cited by 130 · see citing works
Pan, M., Maitin, V., Parathath, S., Andreo, U., Lin, S. X., Germain, C. S., Yao, Z., Maxfield, F. R., Williams, K. J., & Fisher, E. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707460104 · Cited by 128 · see citing works
FoxO1 integrates insulin signaling to VLDL production.
Kamagate, A., & Dong, H. H. (2008) · Cell Cycle · doi:10.4161/cc.7.20.6882 · Cited by 127 · see citing works
Ginsberg, H. N., Le, N., & Gibson, J. C. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111739 · Cited by 125 · see citing works
Self-citationBartlett, S. M., & Gibbons, G. F. (1988) · Biochemical Journal · doi:10.1042/bj2490037 · Cited by 124 · see citing works
Systemic and regional free fatty acid metabolism in type 2 diabetes
Basu, A., Basu, R., Shah, P., Vella, A., Rizza, R. A., & Jensen, M. D. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.6.e1000 · Cited by 123 · see citing works
Phung, T. L., Roncone, A. M., Jensen, K. L. D. M., Sparks, C. E., & Sparks, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.30693 · Cited by 121 · see citing works
Bartels, E. D., Lauritsen, M. L., & Nielsen, L. B. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1233 · Cited by 120 · see citing works
Su, Q., Tsai, J., Xu, E., Qiu, W., Bereczki, E., Sántha, M., & Adeli, K. (2009) · Hepatology · doi:10.1002/hep.22960 · Cited by 118 · see citing works
Allister, E. M., Borradaile, N. M., Edwards, J. Y., & Huff, M. W. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1676 · Cited by 116 · see citing works
Liver fat and lipid oxidation in humans
Kotronen, A., Seppälä‐Lindroos, A., Vehkavaara, S., Bergholm, R., Frayn, K. N., Fielding, B. A., & Yki‐Järvinen, H. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02076.x · Cited by 115 · see citing works
Duez, H., Lamarche, B., Valéro, R., Pavlic, M., Proctor, S. D., Xiao, C., Szeto, L., Patterson, B. W., & Lewis, G. F. (2008) · Circulation · doi:10.1161/circulationaha.107.739888 · Cited by 114 · see citing works
Pavlic, M., Xiao, C., Szeto, L., Patterson, B. W., & Lewis, G. F. (2009) · Diabetes · doi:10.2337/db09-1297 · Cited by 102 · see citing works
Adipose tissue fatty acid metabolism in insulin-resistant men
Bickerton, A. S. T., Roberts, R., Fielding, B. A., Tornqvist, H. E., Blaak, E. E., Wagenmakers, A. J. M., Gilbert, M., Humphreys, S. M., Karpe, F., & Frayn, K. N. (2008) · Diabetologia · doi:10.1007/s00125-008-1040-x · Cited by 100 · see citing works
Endoplasmic Reticulum Stress and the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease
Gentile, C. L., Frye, M. A., & Pagliassotti, M. J. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3790 · Cited by 99 · see citing works
Sparks, J. D., Phung, T. L., Bolognino, M., & Sparks, C. E. (1996) · Biochemical Journal · doi:10.1042/bj3130567 · Cited by 96 · see citing works
Zhang, Y., Hernández‐Ono, A., Ko, C., Yasunaga, K., Huang, L., & Ginsberg, H. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400220200 · Cited by 94 · see citing works
Self-citationChang, B. H., Li, L., Saha, P., & Chan, L. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m004515 · Cited by 94 · see citing works
Rutledge, A. C., Su, Q., & Adeli, K. (2010) · Biochemistry and Cell Biology · doi:10.1139/o09-168 · Cited by 91 · see citing works
The many intersecting pathways underlying apolipoprotein B secretion and degradation
Brodsky, J. L., & Fisher, E. A. A. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.07.002 · Cited by 91 · see citing works
Brown, A.-M., & Gibbons, G. F. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1001.096640 · Cited by 89 · see citing works
Wang, H., Gilham, D., & Lehner, R. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706841200 · Cited by 88 · see citing works
Chirieac, D. V., Chirieac, L. R., Corsetti, J. P., Cianci, J., Sparks, C. E., & Sparks, J. D. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1003 · Cited by 87 · see citing works
Barrows, B. R., Timlin, M. T., & Parks, E. J. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2668 · Cited by 86 · see citing works
Zhu, L., Baker, S. S., Liu, W., Tao, M., Patel, R. A., Nowak, N. J., & Baker, R. D. (2010) · Metabolism · doi:10.1016/j.metabol.2010.10.003 · Cited by 85 · see citing works
Lewis, G. F., Uffelman, K. D., Szeto, L., et al. (1993) · Diabetes · doi:10.2337/diabetes.42.6.833 · Cited by 82 · see citing works
Insulin dose response analysis of free fatty acid kinetics.
Jensen, M., & Nielsen, S. (2007) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2006.08.022 · Cited by 81 · see citing works
From chronic overfeeding to hepatic injury: Role of endoplasmic reticulum stress and inflammation
Mollica, M. P., Lionetti, L., Putti, R., Cavaliere, G., Gaita, M., & Barletta, A. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.10.012 · Cited by 80 · see citing works
Siri, P. W., Candela, N. M., Zhang, Y., Ko, C., Eusufzai, S., Ginsberg, H. N., & Huang, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108909200 · Cited by 77 · see citing works
Self-citationBjörnsson, O. G., DUERDEN, J. M., Bartlett, S. M., et al. (1992) · Biochemical Journal · doi:10.1042/bj2810381 · Cited by 74 · see citing works
Pan, M., Liang, J.-S., Fisher, E. A. A., & Ginsberg, H. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107460200 · Cited by 73 · see citing works
Self-citationEndoplasmic reticulum stress: a new actor in the development of hepatic steatosis
Flamment, M., Kammoun, H. L., Hainault, I., Ferré, P., & Foufelle, F. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283395e5c · Cited by 70 · see citing works
Qiu, W., Zhang, J., Dekker, M. J., Wang, H., Huang, J., Brumell, J. H., & Adeli, K. (2011) · Hepatology · doi:10.1002/hep.24269 · Cited by 66 · see citing works
Sheena, V., Hertz, R., Nousbeck, J., Berman, I., Magenheim, J., & Bar‐Tana, J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400371-jlr200 · Cited by 66 · see citing works
Nonsynonymous Mutations within APOB in Human Familial Hypobetalipoproteinemia
Zhong, S., Magnolo, L., Sundaram, M., Zhou, H., Yao, E. F., Leo, E. D., Loria, P., Wang, S., Bamji‐Mirza, M., Wang, L., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.060467 · Cited by 63 · see citing works
Fatty Acid Flip-Flop in a Model Membrane Is Faster Than Desorption into the Aqueous Phase
Simard, J. R., Pillai, B. K., & Hamilton, J. A. (2008) · Biochemistry · doi:10.1021/bi800697q · Cited by 63 · see citing works
Contribution of Triglyceride-rich Lipoproteins to Plasma Free Fatty Acids
Miles, J. J., & Nelson, R. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-990273 · Cited by 62 · see citing works
Yamaguchi, J., Gamble, M. V., Conlon, D., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306920200 · Cited by 58 · see citing works
The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity
Sajan, M. P., Standaert, M. L., Nimal, S., Varanasi, U., Pastoor, T. E., Mastorides, S., Braun, U., Leitges, M., & Farese, R. V. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800520-jlr200 · Cited by 58 · see citing works
Guo, Q., Avramoglu, R. K., & Adeli, K. (2005) · Metabolism · doi:10.1016/j.metabol.2004.12.014 · Cited by 58 · see citing works
Apolipoprotein B and triacylglycerol secretion in human triacylglycerol hydrolase transgenic mice
Wei, E., Alam, M., Sun, F., Agellon, L. B., Vance, D. E., & Lehner, R. S. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700320-jlr200 · Cited by 57 · see citing works
Characterization of the Murine Mitochondrial Glycerol-3-phosphate Acyltransferase Promoter
Jerkins, A. A., Liu, W. R., Lee, S.-J., & Sul, H. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1416 · Cited by 52 · see citing works
Qiu, W., Su, Q., Rutledge, A. C., Zhang, J., & Adeli, K. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800343-jlr200 · Cited by 51 · see citing works
Qiu, W., Avramoglu, R. K., Rutledge, A. C., Tsai, J., & Adeli, K. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500363-jlr200 · Cited by 47 · see citing works
Precursors of plasma triglyceride fatty acids in obesity
Barter, P. J., & Nestel, P. J. (1973) · Metabolism · doi:10.1016/0026-0495(73)90048-6 · Cited by 43 · see citing works
Lipoprotein metabolism in nonresponders to increased dietary cholesterol.
Ginsberg, H. N., Le, N., Mays, C., Gibson, J. C., & Brown, W. V. (1981) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.1.6.463 · Cited by 43 · see citing works
Self-citationAu, C., Wagner, A., Chong, T. M., et al. (2004) · Metabolism · doi:10.1016/j.metabol.2003.09.011 · Cited by 40 · see citing works
Brodsky, J. L. (2004) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2004.01.004 · Cited by 29 · see citing works
Insulin and oleic acid increase PPARγ2 expression in cultured mouse hepatocytes
Edvardsson, U., Ljungberg, A., & Oscarsson, J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.008 · Cited by 29 · see citing works
Schröder, M., & Sutcliffe, L. K. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-756-3_3 · Cited by 29 · see citing works
Grefhorst, A., & Parks, E. J. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800505-jlr200 · Cited by 26 · see citing works
The Physiological Role of Triacylglycerol Hydrolase in Lipid Metabolism
Gilham, D., & Lehner, R. S. (2004) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/b:remd.0000045101.42431.c7 · Cited by 23 · see citing works
Fatty Acids and Insulin Resistance: A Perfect Storm
Koo, S., & Montminy, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.02.001 · Cited by 20 · see citing works
PNPLeAse Get the Fats Right: Does Lipogenesis or Lipolysis Cause NASH?1,‡
Farrell, G. C. (2010) · Hepatology · doi:10.1002/hep.23867 · Cited by 16 · see citing works
Horton, J. D. (2008) · Science · doi:10.1126/science.1159651 · Cited by 11 · see citing works
Adipose tissue fatty acid metabolism in insulin-resistant men
Bickerton, A. S. T., Roberts, R. R., Fielding, B. A., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1104-y · Cited by 10 · see citing works
Ast, B., Roberts, R. L., Fielding, B., et al. (2008) · Diabetologia · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [108]Melish J Le N-A Ginsberg H Steinberg D Brown WV Dissociation of triglyceride and apoprotein-B production in very low density lipoproteins Am J Physiol 1980 239 E354 E362 7435612
Cited by
Sorted by citations
Pathophysiology of type 2 diabetes mellitus
Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176275 · Cited by 3,360 · see citing works
Sunny, N. E., Parks, E. J., Browning, J. D., & Burgess, S. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.004 · Cited by 672 · see citing works
The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance
Watt, M. J., Miotto, P. M., De Nardo, W., & Montgomery, M. K. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00034 · Cited by 615 · see citing works
Golden, S. H., Brown, A., Cauley, J. A., Chin, M. H., Gary-Webb, T. L., Kim, C., Sosa, J. A., Sumner, A. E., & Anton, B. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2043 · Cited by 405 · see citing works
Zhu, L., Brown, W. C., Cai, Q., Krust, A., Chambon, P., McGuinness, O. P., & Stafford, J. M. (2013) · Diabetes · doi:10.2337/db11-1718 · Cited by 326 · see citing works
Schlein, C., Talukdar, S., Heine, M., Fischer, A. W., Krott, L. M., Nilsson, S. K., Brenner, M. B., Heeren, J., & Scheja, L. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.006 · Cited by 252 · see citing works
Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption
Romano, K. A., Martinez-del Campo, A., Kasahara, K., Chittim, C. L., Vivas, E. I., Amador-Noguez, D., Balskus, E. P., & Rey, F. E. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.021 · Cited by 224 · see citing works
Xiao, C., Dash, S., Morgantini, C., Hegele, R. A., & Lewis, G. F. (2016) · Diabetes · doi:10.2337/db16-0046 · Cited by 212 · see citing works
Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota
Mishra, A. K., Dubey, V., & Ghosh, A. R. (2016) · Metabolism · doi:10.1016/j.metabol.2015.10.008 · Cited by 161 · see citing works
Hypertriglyceridemia in the genomic era: a new paradigm
Lewis, G. F., Xiao, C., & Hegele, R. A. (2015) · Endocrine Reviews · doi:10.1210/er.2014-1062 · Cited by 152 · see citing works
Lipid metabolism in MASLD and MASH: From mechanism to the clinic
Carli, F., Della Pepa, G., Sabatini, S., Vidal Puig, A., & Gastaldelli, A. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101185 · Cited by 147 · see citing works
Determinants of VLDL-triglycerides production
Nielsen, S., & Karpe, F. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283544956 · Cited by 94 · see citing works
Truong, X. T., & Lee, D. H. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2025.0644 · Cited by 84 · see citing works
Hypertriglyceridemia—causes, significance, and approaches to therapy
Santos-Baez, L. S., & Ginsberg, H. N. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00616 · Cited by 66 · see citing works
Self-citationMastrocola, R., Collino, M., Rogazzo, M., Medana, C., Nigro, D., Boccuzzi, G., & Aragno, M. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00450.2012 · Cited by 63 · see citing works
GLP‐1 receptor agonists: effects on the progression of non‐alcoholic fatty liver disease
Liu, J., Wang, G., Jia, Y., & Xu, Y. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2580 · Cited by 48 · see citing works
Hepatic Fatty Acid Balance and Hepatic Fat Content in Humans With Severe Obesity
Lytle, K. A., Bush, N. C., Triay, J. M., Kellogg, T. A., Kendrick, M. L., Swain, J. M., Gathaiya, N. W., Hames, K. C., & Jensen, M. D. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00875 · Cited by 35 · see citing works
Mucinski, J. M., Manrique‐Acevedo, C., Kasumov, T., Garrett, T. J., Gaballah, A., & Parks, E. J. (2020) · Lipids · doi:10.1002/lipd.12244 · Cited by 27 · see citing works
- Authors
- Choi, S. H., & Ginsberg, H. N.
- Affiliations
- Seoul National University (KR)
- Columbia University (US)
- Corresponding author
- Ginsberg, Henry N
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 22
- Issue
- 9
- Pages
- 353-363
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC3163828
- OpenAlex
- W2011523747
- Cited by
- 418
- References
- 171
- Citations by year
- 2026: 33 · 2025: 25 · 2024: 26 · 2023: 26 · 2022: 28 · 2021: 31 · 2020: 41 · 2019: 28 · 2018: 26 · 2017: 29 · 2016: 22 · 2015: 30 · 2014: 24 · 2013: 29 · 2012: 16
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL073030, R01HL055638)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- insulin resistance, very low density lipoprotein secretion, hepatic steatosis, plasma triglycerides, HDL cholesterol, LDL particle size, atherogenesis, steatohepatitis, liver cirrhosis
- MeSH terms
- Fatty Liver, Humans, Insulin Resistance, Lipoproteins, VLDL
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review