The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.
How Taxol® stabilises microtubule structure
Open accessAbstract
The structure of tubulin shows paclitaxel (Taxol(R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The binding of paclitaxel counters the conformational effect of GTP-hydrolysis on microtubules, stabilizing microtubules against depolymerization.69,70”
From Electronic energy migration in microtubules (2023) · cites this paper as [70]
Citations
Cites
MICROTUBULE POLYMERIZATION DYNAMICS
Desai, A. B., & Mitchison, T. J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.83 · Cited by 2,660
Structure of the αβ tubulin dimer by electron crystallography
Nogales, E., Wolf, S., & Downing, K. (1998) · Nature · doi:10.1038/34465 · Cited by 1,623
High-Resolution Model of the Microtubule
Nogales, E., Whittaker, M., Milligan, R. A., & Downing, K. H. (1999) · Cell · doi:10.1016/s0092-8674(00)80961-7 · Cited by 1,200
Crystal structure of the bacterial cell-division protein FtsZ
Löwe, J., & Amos, L. (1998) · Nature · doi:10.1038/34472 · Cited by 920
Self-citationTubulin and FtsZ form a distinct family of GTPases
Nogales, E., Downing, K. H., Amos, L., & L�we, J. (1998) · Nature Structural Biology · doi:10.1038/nsb0698-451 · Cited by 614
Self-citationGuanine nucleotide-dependent assembly of FtsZ into filaments
Mukherjee, A. K., & Lutkenhaus, J. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.9.2754-2758.1994 · Cited by 379
Rigidity of microtubules is increased by stabilizing agents.
Mickey, B., & Howard, J. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.4.909 · Cited by 333
Kurachi, M., Hoshi, M., & Tashiro, H. (1995) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970300306 · Cited by 279
Tubulin and microtubule structure
Downing, K. H., & Nogales, E. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80082-3 · Cited by 273
Analysis of microtubule rigidity using hydrodynamic flow and thermal fluctuations.
Venier, P., Maggs, A. C., Carlier, M., & Pantaloni, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36840-0 · Cited by 259
Cited by
Sorted by citations
Items 201–249 of 249
Shoff, T. A., Derbez-Morin, M., Cai, P., & Julian, R. R. (2026) · PNAS Nexus · doi:10.1093/pnasnexus/pgag034 · Cited by 4
Noh, K. T., Cha, G. S., Kang, T. H., Cho, J., Jung, I. D., Kim, K.-Y., Ahn, S., You, J. C., & Park, Y. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.1.102 · Cited by 3
Lee, G. H., Oh, S. Y., Yeo, K. J., Ferdous, T., Cho, M., & Paik, Y. (2015) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.4183 · Cited by 3
Porphyrins affect the self-assembly of tubulin in solution
Valdez, R., Johnson, E. M., Belcher, J. A., Fuini, J. F., & Brancaleon, L. (2009) · Biophysical Chemistry · doi:10.1016/j.bpc.2009.09.006 · Cited by 3
Shin, S. H., Cha, H. J., Kim, K., An, I., Kim, K.-Y., Ku, J.-E., Jeong, S.-H., & An, S. (2018) · Biomedical Dermatology · doi:10.1186/s41702-017-0016-1 · Cited by 3
Shao, J., Zhang, R., Wu, P., Xu, H., Zhou, Z., Chen, W., Gu, L., Wang, L., Luo, S., Ren, J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2520123123 · Cited by 4
Bangera, M., Wu, J., Beckett, D., Fachet, D., Ferreira, J. L., Voth, G. A., Reber, S., & Moores, C. A. (2026) · Nature Communications · doi:10.1038/s41467-026-70181-0 · Cited by 3
Barnes, E., Guan, X., Alberts, E. M., Thornell, T. L., Warner, C. M., & Pilkiewicz, K. R. (2020) · Crystals · doi:10.3390/cryst10010043 · Cited by 2
de Castro, G. A., Maria, D. A., Rodrigues, C. J., & Sgarbieri, V. C. (2009) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.2008.01220.x · Cited by 2
A Micromechanically Based Anisotropic Constitutive Model for the Microtubule Wall
Arslan, M., & Boyce, M. C. (2012) · Journal of Applied Mechanics · doi:10.1115/1.4005548 · Cited by 2
Yin, F., Sheng, X., Gao, Q., Li, Q., Shi, Z., & Gu, F. (2013) · Animal Cells and Systems · doi:10.1080/19768354.2013.828654 · Cited by 2
Nogales, E., & Alushin, G. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.08056-0 · Cited by 1
Thakuria, B., Purkayastha, D., & Adhikari, S. (2019) · Asia-Pacific Journal of Molecular Biology and Biotechnology · doi:10.35118/apjmbb.2019.027.4.12 · Cited by 1
Role of Biotechnology in the Production of Health Promising Bioactive Molecules
Sharma, M., Sharma, D., Pandey, S. K., Sharma, D., & Sharma, M. (2025) · Sustainable landscape planning and natural resources management · doi:10.1007/978-3-031-76859-0_8 · Cited by 1
Recent Advances in the Biosynthesis and Biotechnological Production of Taxol
Zhu, Y., Liang, F., Chai, P., Kampranis, S. C., & Zhao, Y. (2025) · Engineering · doi:10.1016/j.eng.2025.12.018 · Cited by 1
Effects of peripheral nerve damage on promoting maladaptive plasticity in the spinal cord and brain
Dalrymple, A. N., Senger, J. B., Staples, J. W., Harrison, A. T., Webber, C. A., & Weber, D. J. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.05.016 · Cited by 1
The Drug Development Based on Pathogenetic Research in Alzheimer’s Disease
Lin, X., & Zhang, Q. (2014) · Advances in Alzheimer s Disease · doi:10.4236/aad.2014.32007 · Cited by 1
Computational approaches to enhance activity of taxanes as antimitotic agent
Sivakumar, P. M., Vignesh, N., Kumar, G. R., & Doble, M. (2011) · Medicinal Chemistry Research · doi:10.1007/s00044-011-9779-x · Cited by 1
Clair, J. J. L. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559890-00044 · Cited by 1
XRCC2 knockdown effectively sensitizes esophageal cancer to albumin-paclitaxel in vitro and in vivo
Xu, J., Liu, X., Huang, Z., Lu, T., Zhang, Y., Cai, D., & Li, X. (2024) · Biochemical Genetics · doi:10.1007/s10528-024-10885-4 · Cited by 1
Inhibitors of Mitotic Kinesins for Cancer Treatment: Consequences for Neurons
Kahn, O. I., & Baas, P. W. (2015) · Springer eBooks · doi:10.1007/978-94-017-9732-0_14 · Cited by 1
Chang, J.-H., Kim, K. A., Ahn, S., & Kwon, H.-Y. (2007) · Journal of Life Science · doi:10.5352/jls.2007.17.8.1027 · Cited by 1
A Unifying Hypothesis for the Conformational Change of TubulinPreprint
Fygenson, D. K. (2001) · arXiv (Cornell University) · doi:10.48550/arxiv.physics/0101078 · Cited by 1
Blood pressure simulation model: a teaching aid.
Deepak, K. K. (1992) · PubMed · Cited by 1
Lytvyn, D. I., Yemets, A. I., & Blume, Y. B. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/111484 · Cited by 1
Shao, J., Zhang, R., Wu, P., Xu, H., Zhou, Z., Gu, L., Wang, L., Ren, J., Huang, X., Xie, Q., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.12.632577 · Cited by 1
Magnetic steering at the nanoscale
Stickar, P. G. (2012) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-007339629
Discovery of Inhibitors of Protein–Protein Interactions by Screening Chemical Libraries
Garcı́a-Echeverrı́a, C. (2010) · Wiley eBooks · doi:10.1002/9780470972137.ch6
On the Logic of Natural Product Binding in Protein–Protein Interactivity
Clair, J. J. L. (2010) · Wiley eBooks · doi:10.1002/9780470972137.ch3
Interacciones de los microtúbulos con ligandos activadores de tubulina
Buey, R. M. (2005) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
Microtubule Stability Studied by Integral Equation Theory
Drabik, P., & Kovalenko, A. (2006) · International Conference on MEMS, NANO, and Smart Systems · doi:10.1109/icmens.2005.73
Paclitaxel and obatoclax synergize to kill paclitaxel- resistant small cell lung cancer cells
Manimala, N. J. (2010) · Digital Commons - University of South Florida (University of South Florida)
In Vitro Model for Defining Neurotoxicity of Anticancer Agents
Subramanian, B., Pietraszkiewicz, H., Media, J. E., & Valeriote, F. A. (2015) · CRC Press eBooks · doi:10.1201/b19081-23
Cotton, S. (2011) · Chapman & Hall/CRC eBooks · doi:10.1201/b11443-14
AND TAXOID 5α-O-ACETYLTRANSFERASE
Chau, M. (2004)
Development of polymer and lipid based nano-delivery systems for targeted cancer chemotherapy
Shahin, M. (2012) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3vt1gz32
Polymer ultrasound contrast agents for targeted drug and gene delivery
Cochran, M., & Wheatley, M. A. (2012) · doi:10.17918/etd-7001
Modeling the antitubulin activity of benzimidazol-2-yl carbamates: Mini-review
Obydennov, K. L., Kanwugu, O. N., Kalinina, T. A., & Glukhareva, T. V. (2021) · AIP conference proceedings · doi:10.1063/5.0068469
Characterisation of Zampanolide as a Microtubule-Stabilizing Agent
Field, J. J. (2013) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17142671.v1
(2014) · CRC Press eBooks · doi:10.1201/b17423-69
Cotton, S. (2011) · Chapman & Hall/CRC eBooks · doi:10.1201/b11443-16
Assembling Combinatorial Peptide-Drug Conjugates for Dual-Targeted Treatment of Cancer MetastasisPreprint
Yu, Z., Yu, X., Wang, H., Liu, X., Huang, L., Song, N., Song, Y., Mo, X., & Shi, L. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4113851
Zebrafish as a model for studying peripheral neuropathy
Cádiz, A., & Rieger, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89833-1.00004-5
From tradition to therapy: Medicinal plants as cancer drug repositories
Patel, I., & Anand, A. (2025) · Medicinal Plants - International Journal of Phytomedicines and Related Industries · doi:10.5958/0975-6892.2025.00001.8
Protein-protein interaction inhibitors in cancer
Hardcastle, I. R., Goujon-Ricci, J., & Thompson, W. I. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29808-0.00067-4
Myotoxin 3, a peptide from Crotalus oreganus rattlesnake venom as a microtubule targeting agent
García, M. C. G. (2022) · theses.fr (ABES) · doi:10.70675/2f63b6fdz5c24z4369za50dz5b62780ae1e2
Liu, X. Y., Guo, C., Wang, Y., & Lei, D. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113625
BindingDB (2020) · UC San Diego · doi:10.7270/q2hx1gg1
Metadata
- Authors
- Amos, L. A., & Löwe, J.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 6
- Issue
- 3
- Pages
- R65-R69
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W2025691233
- Cited by
- 248
- References
- 24
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 1 · 2023: 10 · 2022: 10 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 13 · 2014: 16 · 2013: 10 · 2012: 11
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Chemistry & Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Physical Sciences › Chemistry › Organic Chemistry › Heterocyclic Compound Synthesis and Bioactivity
- Keywords
- paclitaxel, microtubule stabilization, beta-tubulin, GTP hydrolysis, microtubule dynamics, drug binding sites
- MeSH terms
- Amino Acid Sequence, Animals, Antineoplastic Agents, Phytogenic, Humans, Microtubules, Molecular Sequence Data, Protein Conformation, Paclitaxel
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review