The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase
Open accessAbstract
The two genetically established antimicrobial mechanisms of macrophages are production of reactive oxygen intermediates by phagocyte oxidase (phox) and reactive nitrogen intermediates by inducible nitric oxide synthase (NOS2). Mice doubly deficient in both enzymes (gp91(phox-/-)/NOS2(-/-)) formed massive abscesses containing commensal organisms, mostly enteric bacteria, even when reared under specific pathogen-free conditions with antibiotics. Neither parental strain showed such infections. Thus, phox and NOS2 appear to compensate for each other's deficiency in providing resistance to indigenous bacteria, and no other pathway does so fully. Macrophages from gp91(phox-/-)/NOS2(-/-) mice could not kill virulent Listeria. Their killing of S. typhimurium, E. coli, and attenuated Listeria was markedly diminished but demonstrable, establishing the existence of a mechanism of macrophage antibacterial activity independent of phox and NOS2.
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Self-citationImpaired immune and acute-phase responses in interleukin-6-deficient mice
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Self-citationCELLULAR RESISTANCE TO INFECTION
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Cited by
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Interferon-γ: an overview of signals, mechanisms and functions
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Neutrophils and immunity: challenges and opportunities
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Antiviral Actions of Interferons
Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
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Metadata
- Authors
- Shiloh, M. U., MacMicking, J. D., Nicholson, S., Brause, J. E., Potter, S., Marino, M., Fang, F., Dinauer, M., & Nathan, C.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 10
- Issue
- 1
- Pages
- 29-38
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2076669998
- Cited by
- 508
- References
- 64
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Shiloh, M. U., MacMicking, J. D., Nicholson, S., Brause, J. E., Potter, S., Marino, M., Fang, F., Dinauer, M., & Nathan, C. (1999). Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase. Immunity. https://doi.org/10.1016/s1074-7613(00)80004-7
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