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Negative Selection of Immature B Cells by Receptor Editing or Deletion Is Determined by Site of Antigen Encounter
Open accessAbstract
Immature B cells that encounter self-antigen are eliminated from the immune repertoire by negative selection. Negative selection has been proposed to take place by two distinct mechanisms: deletion by apoptosis or alteration of the antigen receptor specificity by receptor editing. While convincing evidence exists for each, the two models are inherently contradictory. In this paper, we propose a resolution to this contradiction by demonstrating that the site of first antigen encounter dictates which mechanism of negative selection is utilized. We demonstrate that the bone marrow microenvironment provides signals that block antigen-induced deletion and promote RAG reinduction. In the periphery, the absence of these signals allows the immature B cell to default to apoptosis as a result of BCR engagement.
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Cited by
Role of B cells as antigen presenting cells
Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954936 · Cited by 352
Functional dissection of BCR signaling pathways
Kurosaki, T. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00087-x · Cited by 103
Rekvig, O. P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.569234 · Cited by 42
Phospholipase Cγ2 Contributes to Light-Chain Gene Activation and Receptor Editing
Bai, L., Chen, Y., He, Y., Dai, X., Lin, X., Wen, R., & Wang, D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02273-06 · Cited by 22
Phosphatidylserine synthesis controls oncogenic B cell receptor signaling in B cell lymphoma
Omi, J., Kato, T., Yoshihama, Y., Sawada, K., Kono, N., & Aoki, J. (2024) · Journal of Cell Biology · doi:10.1083/jcb.202212074 · Cited by 18
Metadata
- Authors
- Sandel, P. C., & Monroe, J. G.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 10
- Issue
- 3
- Pages
- 289-299
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2142566270
- Cited by
- 209
- References
- 0
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Negative Selection of Immature B Cells by Receptor Editing or Deletion Is Determined by Site of Antigen Encounter. https://app.cochat.ai/papers/10.1016/s1074-7613(00)80029-1
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- Sandel, P. C., & Monroe, J. G. (1999). Negative Selection of Immature B Cells by Receptor Editing or Deletion Is Determined by Site of Antigen Encounter. Immunity. https://doi.org/10.1016/s1074-7613(00)80029-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
