The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
TGFβ1 Inhibits NF-κB/Rel Activity Inducing Apoptosis of B Cells: Transcriptional Activation of IκBα
Open accessAbstract
TGF beta 1 treatment of B cell lymphomas decreases c-myc gene expression and induces apoptosis. Since we have demonstrated NF-kappa/Rel factors play a key role in transcriptional control of c-myc, we explored the effects of TGF beta1 on WEHI 231 immature B cells. A reduction in NF-kappa B/Rel activity followed TGF beta 1 treatment. In WEHI 231 and CH33 cells, we observed an increase in I kappa B alpha, a specific NF-kappa B/Rel inhibitor, due to transcriptional induction. Engagement of surface CD40 or ectopic c-Rel led to maintenance of NF-kappa B/Rel and c-Myc expression and protection of WEHI 231 cells from TGF beta 1-mediated apoptosis. Ectopic c-Myc expression overrode apoptosis induced by TGF beta 1. Thus, downmodulation of NF-kappa B/Rel reduces c-Myc expression, which leads to apoptosis in these immature B cell models of clonal deletion. The inhibition of NF-kappa B/Rel activity represents a novel TGF beta signaling mechanism.
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Cites
Function and Activation of NF-kappaB in the Immune System
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Cited by
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898
Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer
Catz, S. D., & Johnson, J. L. (2001) · Oncogene · doi:10.1038/sj.onc.1204926 · Cited by 538
Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras
Mayo, M. W., Wang, C.-Y., Cogswell, P. C., Rogers-Graham, K. S., Lowe, S. W., Der, C. J., & Baldwin, A. S. (1997) · Science · doi:10.1126/science.278.5344.1812 · Cited by 533
Borkowski, T. A., Letterio, J. J., Farr, A. G., & Udey, M. C. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.6.2417 · Cited by 474
Nuclear transcription factor-κB as a target for cancer drug development
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Metadata
- Authors
- Arsura, M., Wu, M., & Sonenshein, G. E.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 5
- Issue
- 1
- Pages
- 31-40
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1964094843
- Cited by
- 250
- References
- 4
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Arsura, M., Wu, M., & Sonenshein, G. E. (1996). TGFβ1 Inhibits NF-κB/Rel Activity Inducing Apoptosis of B Cells: Transcriptional Activation of IκBα. Immunity. https://doi.org/10.1016/s1074-7613(00)80307-6
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