The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination
Abstract
The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V(D)J recombination, a series of genomic rearrangements that occur specifically in developing lymphocytes. The recombination activating gene, RAG-1, which is a gene expressed exclusively in maturing lymphoid cells, was previously isolated. RAG-1 inefficiently induced V(D)J recombinase activity when transfected into fibroblasts, but cotransfection with an adjacent gene, RAG-2, has resulted in at least a 1000-fold increase in the frequency of recombination. The 2.1-kilobase RAG-2 complementary DNA encodes a putative protein of 527 amino acids whose sequence is unrelated to that of RAG-1. Like RAG-1, RAG-2 is conserved between species that carry out V(D)J recombination, and its expression pattern correlates precisely with that of V(D)J recombinase activity. In addition to being located just 8 kilobases apart, these convergently transcribed genes are unusual in that most, if not all, of their coding and 3′ untranslated sequences are contained in single exons. RAG-1 and RAG-2 might activate the expression of the V(D)J recombinase but, more likely, they directly participate in the recombination reaction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
Somatic generation of antibody diversity.
Matthyssens, G., Hozumi, N., & Tonegawa, S. (1976) · PubMed · Cited by 3,244
High efficiency transformation of E.coli by high voltage electroporation
Dower, W. J., Miller, J. F., & Ragsdale, C. W. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.13.6127 · Cited by 2,809
Fos and jun: The AP-1 connection
Curran, T., & Franza, B. R. (1988) · Cell · doi:10.1016/0092-8674(88)90024-4 · Cited by 1,567
The V(D)J recombination activating gene, RAG-1
Schatz, D. G., Oettinger, M. A., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90760-5 · Cited by 1,164
Self-citationOrdered rearrangement of immunoglobulin heavy chain variable region segments
Alt, F. W., Yancopoulos, G. D., Blackwell, T. K., Wood, C., Thomas, E., Boss, M., Coffman, R., Rosenberg, N., Tonegawa, S., & Baltimore, D. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb01955.x · Cited by 733
Self-citationAn LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2
Seed, B. (1987) · Nature · doi:10.1038/329840a0 · Cited by 681
DYNAMIC, STRUCTURAL, AND REGULATORY ASPECTS OF λ SITE-SPECIFIC RECOMBINATION
Landy, A. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.004405 · Cited by 612
Developmental regulation of T-cell receptor gene expression
Raulet, D. H., Garman, R. D., Saito, H., & Tonegawa, S. (1985) · Nature · doi:10.1038/314103a0 · Cited by 517
Alt, F., Rosenberg, N., Lewis, S., Thomas, E., & Baltimore, D. (1981) · Cell · doi:10.1016/0092-8674(81)90421-9 · Cited by 484
Self-citation
Cited by
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Shinkai, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90029-c · Cited by 2,150
The Evolution of Adaptive Immune Systems
Cooper, M. D., & Alder, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.02.001 · Cited by 873
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
Agrawal, A., Eastman, Q. M., & Schatz, D. G. (1998) · Nature · doi:10.1038/29457 · Cited by 811
Self-citationReceptor editing in self-reactive bone marrow B cells.
Tiegs, S. L., Russell, D. M., & Nemazee, D. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.4.1009 · Cited by 766
Roles and regulation of histone methylation in animal development
Jambhekar, A., Dhall, A., & Shi, Y. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0151-1 · Cited by 556
Metadata
- Authors
- Oettinger, M. A., Schatz, D. G., Gorka, C., & Baltimore, D.
- Venue
- Science
- Published
- 1990-06-22
- Volume
- 248
- Issue
- 4962
- Pages
- 1517-1523
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068012172
- Cited by
- 1,456
- References
- 29
- FWCI
- 23.64
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination. https://app.cochat.ai/papers/10.1126/science.2360047
- The paper
- Oettinger, M. A., Schatz, D. G., Gorka, C., & Baltimore, D. (1990). RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination. Science. https://doi.org/10.1126/science.2360047
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
