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Cited by 324

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis

Open access
Coughlin, Christina M., Salhany, Kevin E., Gee, Michael S., LaTemple, Denise C., Kotenko, Serguei, Ma, XiaoJing, Gri, Giorgia, Wysocka, Maria, Kim, Ji Eun, Liu, Li, Liao, Fang, Farber, Joshua M., Pestka, Sidney, Trinchieri, Giorgio, Lee, William M.F.·1998·Immunity
DOI 10.1016/s1074-7613(00)80585-3
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Abstract

Expression of a dominant negative mutant IFNgammaR1 in murine SCK and K1735 tumor cells rendered them relatively unresponsive to IFNgamma in vitro and more tumorigenic and less responsive to IL-12 therapy in vivo. IL-12 induced histologic evidence of ischemic damage only in IFNgamma-responsive tumors, and in vivo Matrigel vascularization assays revealed that while IFNgamma-responsive and -unresponsive tumor cells induced angiogenesis equally well, IL-12 and its downstream mediator IFNgamma only inhibited angiogenesis induced by the responsive cells. IL-12 induced angiogenesis inhibitory activity in the responsive cells, which may be attributable to production of the chemokine IP-10. Thus, IL-12 and IFNgamma inhibit tumor growth by inducing tumor cells to generate antiangiogenic activity.

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Metadata

Authors
Coughlin, C. M., Salhany, K. E., Gee, M. S., LaTemple, D. C., Kotenko, S., Ma, X., Gri, G., Wysocka, M., Kim, J. E., Liu, L., Liao, F., Farber, J. M., Pestka, S., Trinchieri, G., & Lee, W. M. F.
Venue
Immunity
Publisher
Elsevier BV
Published
1998-07
Volume
9
Issue
1
Pages
25-34
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/s1074-7613(00)80585-3
OpenAlex
W2010925210
Cited by
324
References
35
FWCI
6.87
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis. https://app.cochat.ai/papers/10.1016/s1074-7613(00)80585-3
The paper
Coughlin, C. M., Salhany, K. E., Gee, M. S., LaTemple, D. C., Kotenko, S., Ma, X., Gri, G., Wysocka, M., Kim, J. E., Liu, L., Liao, F., Farber, J. M., Pestka, S., Trinchieri, G., & Lee, W. M. F. (1998). Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis. Immunity. https://doi.org/10.1016/s1074-7613(00)80585-3

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.