The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
LAT Palmitoylation
Open accessAbstract
The linker molecule LAT is a critical substrate of the tyrosine kinases activated upon TCR engagement. Phosphorylated LAT binds Grb2, PLC-gamma1, and other signaling molecules. We demonstrate that human LAT is palmitoylated and that palmitoylated LAT predominantly localizes into glycolipid-enriched microdomains (GEMs). Although the LAT transmembrane domain is sufficient for membrane localization, palmitoylation at C26 and C29 is essential for efficient partitioning into GEMs. LAT palmitoylation is necessary for its tyrosine phosphorylation. After T cell activation, most tyrosine-phosphorylated LAT molecules and a fraction of PLC-gamma1 and other signaling molecules are present in GEMs. LAT is central to T cell activation and is a novel linker molecule shown to require targeting to membrane microdomains for signaling.
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Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Protein modules and signalling networks
Pawson, T. (1995) · Nature · doi:10.1038/373573a0 · Cited by 2,420
Regulation of Phosphoinositide-specific Phospholipase C Isozymes
Rhee, S. G., & Bae, Y. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15045 · Cited by 876
Cited by
Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Regulation of Phosphoinositide-Specific Phospholipase C
Rhee, S. G. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.281 · Cited by 1,628
T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains
Viola, A., Schroeder, S., Sakakibara, Y., & Lanzavecchia, A. (1999) · Science · doi:10.1126/science.283.5402.680 · Cited by 938
Immunological decision‐making: how does the immune system decide to mount a helper T‐cell response?
Kaiko, G. E., Horvat, J. C., Beagley, K. W., & Hansbro, P. M. (2008) · Immunology · doi:10.1111/j.1365-2567.2007.02719.x · Cited by 658
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
Bunnell, S. C., Hong, D. I., Kardon, J. R., Yamazaki, T., McGlade, C. J., Barr, V. A., & Samelson, L. E. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200203043 · Cited by 632
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Metadata
- Authors
- Zhang, W., Trible, R. P., & Samelson, L. E.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 9
- Issue
- 2
- Pages
- 239-246
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W95054676
- Cited by
- 838
- References
- 3
- FWCI
- 26.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, W., Trible, R. P., & Samelson, L. E. (1998). LAT Palmitoylation. Immunity. https://doi.org/10.1016/s1074-7613(00)80606-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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