The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.
Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells
Open accessAbstract
Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) T cells express the CD45RA(-)CD62L(-) but lack the CD45RA(+)CD62L(-) T cell effector memory (T(EM)) phenotype. This skewing is not found in CMV- and EBV-specific CD8(+) T cells in HIV-infected individuals. CD95/Fas-induced apoptosis is much higher in the CD45RA(-)CD62L(-) T(EM) cells. However, cytotoxicity and IFNgamma production by HIV-specific CD8(+) T cells is not impaired. Our data suggest that the survival and differentiation of HIV-specific CD8(+) T cells may be compromised by CD95/Fas apoptosis induced by FasL-expressing HIV-infected cells.
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“CMV-specific CD8+ T cells, rather than being resistant to apoptosis, are equally as susceptible to Fas-L/Fas-R induced apoptosis as the total pool of CD8+ T cells (Mueller et al. 2001).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Mueller et al. 2001
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1 retracted
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RetractedTwo subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA
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Wherry, E. J., Blattman, J. N., Murali‐Krishna, K., der Most, R. G. V., & Ahmed, R. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4911-4927.2003 · Cited by 1,645
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
Appay, V., Dunbar, P. R., Callan, M. F. C., Klenerman, P., Gillespie, G. M. A., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., et al. (2002) · Nature Medicine · doi:10.1038/nm0402-379 · Cited by 1,556
Migueles, S. A., Laborico, A. C., Shupert, W. L., Sabbaghian, M. S., Rabin, R. L., Hallahan, C. W., van Baarle, D., Kostense, S., Miedema, F. F., McLaughlin, M. E., et al. (2002) · Nature Immunology · doi:10.1038/ni845 · Cited by 1,004
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
Petrovas, C., Casazza, J. P., Brenchley, J. M., Price, D. A., Gostick, E., Adams, W. C., Precopio, M. L., Schacker, T., Roederer, M., Douek, D. C., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061496 · Cited by 889
Self-citationThe who's who of T ‐cell differentiation: Human memory T ‐cell subsets
Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817
Self-citation
Metadata
- Authors
- Mueller, Y. M., De Rosa, S. C., Hutton, J. A., Witek, J., Roederer, M., Altman, J. D., & Katsikis, P. D.
- Affiliations
- Hahnemann University Hospital (US)
- National Institutes of Health (US)
- Emory University (US)
- Corresponding author
- Katsikis, Peter D
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 15
- Issue
- 6
- Pages
- 871-882
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2044870374
- Cited by
- 164
- References
- 48
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 9 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 7 · 2013: 7 · 2012: 4
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01 AI46719, R01AI046719)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- HIV-specific CD8+ T cells, Fas ligand, T cell survival, T cell differentiation, effector memory T cells, CD45RA, L-selectin, cytotoxicity, IFN-gamma production, HIV infection, cytotoxic T lymphocytes
- MeSH terms
- Adult, Cell Differentiation, Cytomegalovirus, Cytotoxicity, Immunologic, Herpesvirus 4, Human, HIV, Humans, Immunologic Memory, Interferon-gamma, Macrophages, T-Lymphocytes, Cytotoxic, HIV Infections, Immunophenotyping, T-Lymphocyte Subsets, Apoptosis, Leukocyte Common Antigens, Coculture Techniques, fas Receptor, L-Selectin, Viral Load
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