Cited by 164HIV Research and TreatmentT-cell and B-cell ImmunologyCell death mechanisms and regulation

The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.

Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells

Open access

Mueller, Yvonne M, De Rosa, Stephen C, Hutton, Justin A, Witek, James, Roederer, Mario, Altman, John D, Katsikis, Peter D·2001·Immunity

DOI 10.1016/s1074-7613(01)00246-1

Open this paper in CoChat — free account Open PDF

Abstract

Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) T cells express the CD45RA(-)CD62L(-) but lack the CD45RA(+)CD62L(-) T cell effector memory (T(EM)) phenotype. This skewing is not found in CMV- and EBV-specific CD8(+) T cells in HIV-infected individuals. CD95/Fas-induced apoptosis is much higher in the CD45RA(-)CD62L(-) T(EM) cells. However, cytotoxicity and IFNgamma production by HIV-specific CD8(+) T cells is not impaired. Our data suggest that the survival and differentiation of HIV-specific CD8(+) T cells may be compromised by CD95/Fas apoptosis induced by FasL-expressing HIV-infected cells.

Integrity signals

Registry

Crossref · 10.1016/s1074-7613(01)00246-1

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

HIV-specific cytotoxic T lymphocytes traffic to lymph nodes and localize at sites of HIV replication and cell death
Brodie, S. J., Patterson, B. K., Lewinsohn, D. A., Diem, K., Spach, D. H., Greenberg, P. D., Riddell, S. R., & Corey, L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8707 · Cited by 91
Retracted
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544
Self-citation
Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
Borrow, P., Lewicki, H. A., Hahn, B. H., Shaw, G. M., & Oldstone, M. B. A. (1994) · Journal of Virology · doi:10.1128/jvi.68.9.6103-6110.1994 · Cited by 1,880
Vigorous HIV-1-Specific CD4 + T Cell Responses Associated with Control of Viremia
Rosenberg, E. S., Billingsley, J. M., Caliendo, A. M., Boswell, S. L., Sax, P. E., Kalams, S. A., & Walker, B. D. (1997) · Science · doi:10.1126/science.278.5342.1447 · Cited by 1,832
Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA
Ogg, G. S., Jin, X., Bonhoeffer, S., Dunbar, P. R., Nowak, M. A., Monard, S. P., Segal, J. P., Cao, Y., Rowland‐Jones, S., Cerundolo, V., et al. (1998) · Science · doi:10.1126/science.279.5359.2103 · Cited by 1,381
Phenotypic and functional separation of memory and effector human CD8+ T cells
Hamann, D., Baars, P. A., Rep, M. H. G., Hooibrink, B., Kerkhof-Garde, S. R., Klein, M. R., & Lier, R. A. W. V. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1407 · Cited by 1,366
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection
Matloubian, M., Concepcion, R. J., & Ahmed, R. (1994) · Journal of Virology · doi:10.1128/jvi.68.12.8056-8063.1994 · Cited by 1,162
Immune control of HIV-1 after early treatment of acute infection
Rosenberg, E. S., Altfeld, M. A., Poon, S. H. T., Phillips, M. N., Wilkes, B. M., Eldridge, R. L., Robbins, G. K., D’Aquila, R. T., Goulder, P., & Walker, B. D. (2000) · Nature · doi:10.1038/35035103 · Cited by 1,002

Show all 48 references

Sorted by citations

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment
Wherry, E. J., Blattman, J. N., Murali‐Krishna, K., der Most, R. G. V., & Ahmed, R. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4911-4927.2003 · Cited by 1,645
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
Appay, V., Dunbar, P. R., Callan, M. F. C., Klenerman, P., Gillespie, G. M. A., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., et al. (2002) · Nature Medicine · doi:10.1038/nm0402-379 · Cited by 1,556
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
Migueles, S. A., Laborico, A. C., Shupert, W. L., Sabbaghian, M. S., Rabin, R. L., Hallahan, C. W., van Baarle, D., Kostense, S., Miedema, F. F., McLaughlin, M. E., et al. (2002) · Nature Immunology · doi:10.1038/ni845 · Cited by 1,004
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
Petrovas, C., Casazza, J. P., Brenchley, J. M., Price, D. A., Gostick, E., Adams, W. C., Precopio, M. L., Schacker, T., Roederer, M., Douek, D. C., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061496 · Cited by 889
Self-citation
The who's who of T ‐cell differentiation: Human memory T ‐cell subsets
Mahnke, Y. D., Brodie, T. M., Sallusto, F., Roederer, M., & Lugli, E. (2013) · European Journal of Immunology · doi:10.1002/eji.201343751 · Cited by 817
Self-citation
Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan
Campbell, J. P., & Turner, J. E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00648 · Cited by 736
T Cell Dynamics in HIV-1 Infection
Douek, D. C., Picker, L. J., & Koup, R. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141053 · Cited by 579
T-Cell Subsets That Harbor Human Immunodeficiency Virus (HIV) In Vivo: Implications for HIV Pathogenesis
Brenchley, J. M., Hill, B. J., Ambrozak, D. R., Price, D. A., Guenaga, J., Casazza, J. P., Kuruppu, J. C., Yazdani, J., Migueles, S. A., Connors, M., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.3.1160-1168.2004 · Cited by 394
Self-citation
Molecular Signatures Distinguish Human Central Memory from Effector Memory CD8 T Cell Subsets
Willinger, T., Freeman, T. C., Hasegawa, H., McMichael, A. J., & Callan, M. F. C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5895 · Cited by 256
CD57+ T lymphocytes and functional immune deficiency
Focosi, D., Bestagno, M., Burrone, Ó. R., & Petrini, M. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809566 · Cited by 253
Phenotype, Function, and Gene Expression Profiles of Programmed Death-1hi CD8 T Cells in Healthy Human Adults
Duraiswamy, J., Ibegbu, C., Masopust, D., Miller, J. D., Araki, K., Doho, G., Tata, P., Sk, G., Zilliox, M. J., Nakaya, H. I., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001783 · Cited by 246
Apoptosis as an HIV strategy to escape immune attack
Gougeon, M. (2003) · Nature reviews. Immunology · doi:10.1038/nri1087 · Cited by 233
Beyond six colors: A new era in flow cytometry
Rosa, S. C. D., Brenchley, J. M., & Roederer, M. (2003) · Nature Medicine · doi:10.1038/nm0103-112 · Cited by 204
Self-citation
Live and Let Die
Fackler, O., & Baur, A. S. (2002) · Immunity · doi:10.1016/s1074-7613(02)00307-2 · Cited by 203
Virus Infection and Death Receptor-Mediated Apoptosis
Zhou, X., Jiang, W., Liu, Z., Liu, S., & Liang, X. (2017) · Viruses · doi:10.3390/v9110316 · Cited by 197
Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection
Yamamoto, T., Price, D. A., Casazza, J. P., Ferrari, G., Nason, M., Chattopadhyay, P. K., Roederer, M., Emma Gostick, D., Katsikis, P. D., Douek, D. C., et al. (2011) · Blood · doi:10.1182/blood-2010-11-317297 · Cited by 193
Self-citation
Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion
Bucks, C. M., Norton, J., Boesteanu, A. C., Mueller, Y. M., & Katsikis, P. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0800997 · Cited by 192
Self-citation
Hide, shield and strike back: how HIV-infected cells avoid immune eradication
Peterlin, B. M., & Trono, D. (2003) · Nature reviews. Immunology · doi:10.1038/nri998 · Cited by 176
SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection
Petrovas, C., Price, D. A., Mattapallil, J. J., Ambrozak, D. R., Geldmacher, C., Cecchinato, V., Vaccari, M., Tryniszewska, E. A., Emma Gostick, D., Roederer, M., et al. (2007) · Blood · doi:10.1182/blood-2007-01-069112 · Cited by 172
Self-citation
Premature ageing of the immune system: the cause of AIDS?
Appay, V., & Rowland-Jones, S. L. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02338-4 · Cited by 173
Coinfection With HIV-1 and HCV—A One-Two Punch
Kim, A. Y., & Chung, R. T. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.06.040 · Cited by 171
Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells
Hale, M. R., Mesojednik, T. D., Ibarra, G. S. R., Sahni, J., Bernard, A., Sommer, K., Scharenberg, A. M., Rawlings, D. J., & Wagner, T. A. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.12.023 · Cited by 174
Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection
Price, D. A., Asher, T. E., Wilson, N. A., Nason, M., Brenchley, J. M., Metzler, I. S., Venturi, V., Emma Gostick, D., Chattopadhyay, P. K., Roederer, M., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081127 · Cited by 155
Self-citation
Regulatory T Cells Secreting IL-10 Dominate the Immune Response to EBV Latent Membrane Protein 1
Marshall, N. A., Vickers, M. A., & Barker, R. N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.12.6183 · Cited by 152
Impact of Epitope Escape on PD-1 Expression and CD8 T-Cell Exhaustion during Chronic Infection
Blattman, J. N., Wherry, E. J., Ha, S., der Most, R. G. V., & Ahmed, R. (2009) · Journal of Virology · doi:10.1128/jvi.02524-08 · Cited by 142
Lessons from the study of T-cell differentiation in persistent human virus infection
Appay, V., & Rowland‐Jones, S. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2004.02.007 · Cited by 136
IL-15 enhances survival and function of HIV-specific CD8+ T cells
Mueller, Y. M., Bojczuk, P. M., Halstead, E. S., Kim, A. H. J., Witek, J., Altman, J. D., & Katsikis, P. D. (2003) · Blood · doi:10.1182/blood-2002-07-1957 · Cited by 134
Self-citation
HIV-specific CD8+ T cells and HIV eradication
Jones, R. B., & Walker, B. D. (2016) · Journal of Clinical Investigation · doi:10.1172/jci80566 · Cited by 134
CD27 Expression Promotes Long-Term Survival of Functional Effector–Memory CD8+Cytotoxic T Lymphocytes in HIV-infected Patients
Ochsenbein, A. F., Riddell, S. R., Brown, M., Corey, L., Baerlocher, G. M., Lansdorp, P. M., & Greenberg, P. D. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040717 · Cited by 131
Interleukin-15 Increases Effector Memory CD8+T Cells and NK Cells in Simian Immunodeficiency Virus-Infected Macaques
Mueller, Y. M., Petrovas, C., Bojczuk, P. M., Dimitriou, I. D., Beer, B., Silvera, P. M., Villinger, F. J., Cairns, J. S., Gracely, E. J., Lewis, M. G., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.8.4877-4885.2005 · Cited by 119
Self-citation
Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8+ T Cells in HIV Infection
Petrovas, C., Chaon, B., Ambrozak, D. R., Price, D. A., Melenhorst, J. J., Hill, B. J., Geldmacher, C., Casazza, J. P., Chattopadhyay, P. K., Roederer, M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900182 · Cited by 114
Self-citation
Mechanisms of CD8 + T cell‐mediated suppression of HIV/SIV replication
McBrien, J. B., Kumar, N., & Silvestri, G. (2018) · European Journal of Immunology · doi:10.1002/eji.201747172 · Cited by 111
Is immunosenescence influenced by our lifetime “dose” of exercise?
Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112
Apoptosis of uninfected cells induced by HIV envelope glycoproteins
Ahr, B., Robert-Hebmann, V., Devaux, C. A., & Biard‐Piechaczyk, M. (2004) · Retrovirology · doi:10.1186/1742-4690-1-12 · Cited by 105
IL-15 Treatment during Acute Simian Immunodeficiency Virus (SIV) Infection Increases Viral Set Point and Accelerates Disease Progression despite the Induction of Stronger SIV-Specific CD8+ T Cell Responses
Mueller, Y. M., Do, D. H., Altork, S. R., Artlett, C. M., Gracely, E. J., Katsetos, C. D., Legido, A., Villinger, F. J., Altman, J. D., Brown, C. R., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.350 · Cited by 102
Self-citation
Distinct Mechanisms of CD4+and CD8+T-Cell Activation and Bystander Apoptosis Induced by Human Immunodeficiency Virus Type 1 Virions
Holm, G. H., & Gabuzda, D. H. (2005) · Journal of Virology · doi:10.1128/jvi.79.10.6299-6311.2005 · Cited by 92
Type I Interferon Upregulates Bak and Contributes to T Cell Loss during Human Immunodeficiency Virus (HIV) Infection
Fraietta, J. A., Mueller, Y. M., Yang, G., Boesteanu, A. C., Gracias, D. T., Do, D. H., Hope, J. L., Kathuria, N., McGettigan, S. E., Lewis, M. G., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003658 · Cited by 93
Self-citation
HIV: current opinion in escapology
Klenerman, P., Wu, Y., & Phillips, R. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00339-9 · Cited by 92
Immediate Early Effector Functions of Virus-Specific CD8+CCR7+ Memory Cells in Humans Defined by HLA and CC Chemokine Ligand 19 Tetramers
Ravkov, E. V., Myrick, C., & Altman, J. D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2461 · Cited by 89
Self-citation
HIV-1-Specific Memory CD4+ T Cells Are Phenotypically Less Mature Than Cytomegalovirus-Specific Memory CD4+ T Cells
Yue, F. Y., Kovacs, C. M., Dimayuga, R. C., Parks, P., & Ostrowski, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2476 · Cited by 88
The role of CD8+ T-cell response in HIV infection.
Benito, J. M., López, M., & Soriano, V. (2004) · PubMed · Cited by 85
Pro- and anti-apoptotic CD95 signaling in T cells
Paulsen, M., & Janßen, O. (2011) · Cell Communication and Signaling · doi:10.1186/1478-811x-9-7 · Cited by 87
Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation
Zhao, M., Kiernan, C. H., Stairiker, C. J., Hope, J. L., León, L. G., van Meurs, M., Brouwers-Haspels, I., Boers, R., Boers, J., Gribnau, J. H., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008555 · Cited by 81
Self-citation
Dysfunctional HIV-Specific CD8+ T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis
Gaiha, G. D., McKim, K. J., Woods, M. W., Pertel, T., Rohrbach, J., Barteneva, N. S., Chin, C. R., Liu, D., Soghoian, D. Z., Cesa, K. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.011 · Cited by 76
Coinhibitory receptors and CD8 T cell exhaustion in chronic infections
Kuchroo, V. K., Anderson, A. C., & Petrovas, C. (2014) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000088 · Cited by 76
Profound metabolic, functional, and cytolytic differences characterize HIV-specific CD8 T cells in primary and chronic HIV infection
Trautmann, L., Mbitikon-Kobo, F. M., Goulet, J.-P., Peretz, Y., Shi, Y., van Grevenynghe, J., Procopio, F. A., Boulassel, M. R., Routy, J., Chomont, N., et al. (2012) · Blood · doi:10.1182/blood-2012-04-422550 · Cited by 74
Virus Infections
Xu, X., Screaton, G. R., & McMichael, A. J. (2001) · Immunity · doi:10.1016/s1074-7613(01)00255-2 · Cited by 73
Expansion of activated human naïve T-cells precedes effector function
Brenchley, J. M., Douek, D. C., Ambrozak, D. R., Chatterji, M., Betts, M. R., Davis, L. S., & Koup, R. A. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.02015.x · Cited by 71
Does Regular Exercise Counter T Cell Immunosenescence Reducing the Risk of Developing Cancer and Promoting Successful Treatment of Malignancies?
Turner, J. E., & Brum, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4234765 · Cited by 66
Decreased effector memory CD45RA+ CD62L- CD8+ T cells and increased central memory CD45RA- CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients
Maldonado, A., Mueller, Y. M., Thomas, P., Bojczuk, P. M., O'Connors, C., & Katsikis, P. D. (2003) · Arthritis Research & Therapy · doi:10.1186/ar619 · Cited by 65
Self-citation
Pathogen-Induced Proapoptotic Phenotype and High CD95 (Fas) Expression Accompany a Suboptimal CD8+ T-Cell Response: Reversal by Adenoviral Vaccine
Vasconcelos, J. R., Bruña–Romero, O., Araújo, A. F., Dominguez, M. R., Ersching, J., de Alencar, B. C., Machado, A. V., Gazzinelli, R. T., Bortoluci, K. R., Amarante-Mendes, G. P., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002699 · Cited by 64
Antigen Burden Is a Major Determinant of Human Immunodeficiency Virus–Specific CD8+T Cell Maturation State: Potential Implications for Therapeutic Immunization
Tussey, L., Nair, U. S., Bachinsky, M., Edwards, B. H., Bakari, J., Grimm, K. M., Joyce, J. G., Vessey, R., Steigbigel, R. T., Robertson, M. N., et al. (2003) · The Journal of Infectious Diseases · doi:10.1086/367707 · Cited by 62
Preferential Apoptosis of HIV-1-Specific CD4+ T Cells
Yue, F. Y., Kovacs, C. M., Dimayuga, R. C., Gu, X. X. J., Parks, P., Kaul, R., & Ostrowski, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2196 · Cited by 64
IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells
Mueller, Y. M. (2002) · International Immunology · doi:10.1093/intimm/dxg013 · Cited by 62
Self-citation
Relationship between the frequency of HIV-specific CD8 + T cells and the level of CD38 + CD8 + T cells in untreated HIV-infected individuals
Chun, T., Justement, J. S., Sanford, C., Hallahan, C. W., Planta, M. A., Loutfy, M. R., Kottilil, S., Moir, S. L., Kovacs, C. M., & Fauci, A. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307328101 · Cited by 60
Insights Into Persistent HIV-1 Infection and Functional Cure: Novel Capabilities and Strategies
Ta, T. M., Malik, S., Anderson, E. M., Jones, A. D., Perchik, J., Freylikh, M., Sardo, L., Klase, Z. A., & Izumi, T. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.862270 · Cited by 61
Apoptosis in SIV infection
Hurtrel, B., Petit, F., Arnoult, D., Müller-Trutwin, M. C., Silvestri, G., & Estaquier, J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401600 · Cited by 60
HIV/SIV Infection Primes Monocytes and Dendritic Cells for Apoptosis
Laforge, M., Campillo-Gimenez, L., Monceaux, V., Cumont, M., Hurtrel, B., Corbeil, J., Zaunders, J. J., Elbim, C., & Estaquier, J. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002087 · Cited by 58
HIV-Specific CD8+ T Cells Exhibit Markedly Reduced Levels of Bcl-2 and Bcl-xL
Petrovas, C., Mueller, Y. M., Dimitriou, I. D., Bojczuk, P. M., Mounzer, K., Witek, J., Altman, J. D., & Katsikis, P. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4444 · Cited by 58
Self-citation
Caspase-dependent and -independent T-cell death pathways in pathogenic simian immunodeficiency virus infection: relationship to disease progression
Arnoult, D., Petit, F., Lelièvie, J. D., Lecossier, D., Hance, A. J., Monceaux, V., Fang, R. H. T., Huntrel, B., Ameisen, J., & Estaquier, J. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401289 · Cited by 62
The multiple roles of Fas ligand in the pathogenesis of infectious diseases
Dockrell, D. H. (2003) · Clinical Microbiology and Infection · doi:10.1046/j.1469-0691.2003.00669.x · Cited by 56
HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation
Muthumani, K., Choo, A. Y., Hwang, D. S., Arumugam, P., Dayes, N. S., Harris, C. A., Green, D. R., Wadsworth, S. A., Siekierka, J. J., & Weiner, D. B. (2005) · Blood · doi:10.1182/blood-2005-03-0932 · Cited by 53
HIV-1 and IL-1β regulate Fas ligand expression in human astrocytes through the NF-κB pathway
Ghorpade, A., Hölter, S. M., Borgmann, K., Persidsky, R., & Wu, L. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00222-4 · Cited by 51
Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta
Wentink, M., Mueller, Y. M., Dalm, V., Driessen, G., van Hagen, P. V., van Montfrans, J. V., van der Burg, M., & Katsikis, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00446 · Cited by 48
Self-citation
Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8+ T cells
Petrovas, C., Mueller, Y. M., Dimitriou, I. D., Altork, S. R., Banerjee, A., Sklar, P. A., Mounzer, K., Altman, J. D., & Katsikis, P. D. (2006) · Blood · doi:10.1182/blood-2006-05-021626 · Cited by 50
Self-citation
T cell toxicity of HIV latency reversing agents
Zhao, M., Crignis, E. D., Rokx, C., Verbon, A., van Gelder, T., Mahmoudi, T., Katsikis, P. D., & Mueller, Y. M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.10.023 · Cited by 48
Self-citation
Live Attenuated Lentivirus Infection Elicits Polyfunctional Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells with Reduced Apoptotic Susceptibility in Rhesus Macaques that Control Virus Replication after Challenge with Pathogenic SIVmac239
Genescà, M., Rourke, T., Li, J., Bost, K., Chohan, B., McChesney, M. B., & Miller, C. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4732 · Cited by 47
Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naïve HIV-positive patients
Nasi, M., Pinti, M., Bugarini, R., Troiano, L., Lugli, E., Bellodi, C., Mussini, C., Borghi, V., Trenti, T., Balli, F., et al. (2005) · Immunogenetics · doi:10.1007/s00251-005-0031-z · Cited by 45
HIV-Specific CD8+T Cells from Elite Controllers Are Primed for Survival
Yan, J., Sabbaj, S., Bansal, A., Amatya, N., Shacka, J. J., Goepfert, P., & Heath, S. L. (2013) · Journal of Virology · doi:10.1128/jvi.02379-12 · Cited by 43
Quarter Century of Anti-HIV CAR T Cells
Wagner, T. A. (2018) · Current HIV/AIDS Reports · doi:10.1007/s11904-018-0388-x · Cited by 44
T-Cell Signaling in HIV-1 Infection
Abbas, W., & Herbein, G. (2013) · The Open Virology Journal · doi:10.2174/1874357920130621001 · Cited by 40
Tumor Necrosis Factor Receptor/Tumor Necrosis Factor Family Members in Antiviral CD8 T-Cell Immunity
Salek‐Ardakani, S., & Croft, M. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0026 · Cited by 41
HIV‐1 Nef equips dendritic cells to reduce survival and function of CD8 + T cells: a mechanism of immune evasion
Quaranta, M. G., Mattioli, B., Giordani, L., & Viora, M. (2004) · The FASEB Journal · doi:10.1096/fj.04-1633fje · Cited by 41
CD8+ T Cell Dynamics during Primary Simian Immunodeficiency Virus Infection in Macaques: Relationship of Effector Cell Differentiation with the Extent of Viral Replication
Monceaux, V., Viollet, L., Petit, F., Fang, R. H. T., Cumont, M., Zaunders, J. J., Hurtrel, B., & Estaquier, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6898 · Cited by 40
FAS mediates apoptosis, inflammation, and treatment of pathogen infection
Hu, L., Lu, J., Fan, H., Niu, C., Han, Y., Caiyin, Q., Wu, H., & Qiao, J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1561102 · Cited by 43
The immunoregulatory effects of HIV‐1 Nef on dendritic cells and the pathogenesis of AIDS
Quaranta, M. G., Mattioli, B., Giordani, L., & Viora, M. (2006) · The FASEB Journal · doi:10.1096/fj.06-6260rev · Cited by 36
HIV-associated memory B cell perturbations
Hu, Z., Luo, Z., Wan, Z., Wu, H., Li, W., Zhang, T., & Jiang, W. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.04.008 · Cited by 36
Quantitative studies of CD8+ T-cell responses during microbial infection
Serbina, N. V., & Pamer, E. G. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(03)00071-2 · Cited by 35
Altered T cell differentiation associated with loss of CD27 and CD28 in HIV infected Indian individuals
Mojumdar, K., Vajpayee, M., Chauhan, N. K., Singh, A., Singh, R., & Kurapati, S. (2011) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20610 · Cited by 36
HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4 + T Cells
Prévost, J., Edgar, C. R., Richard, J., Trothen, S. M., Jacob, R. A., Mumby, M. J., Pickering, S., Dubé, M., Kaufmann, D., Kirchhoff, F., et al. (2020) · Journal of Virology · doi:10.1128/jvi.01999-19 · Cited by 36
Intrinsic and extrinsic pathways signaling during HIV-1 mediated cell death
Petit, F., Arnoult, D., Viollet, L., & Estaquier, J. (2003) · Biochimie · doi:10.1016/j.biochi.2003.09.007 · Cited by 32
The CD8 + T Cell Noncytotoxic Antiviral Responses
Morvan, M. G., Teque, F., Locher, C. P., & Levy, J. A. (2021) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00155-20 · Cited by 34
Human and Simian Immunodeficiency Virus-Mediated Upregulation of the Apoptotic Factor TRAIL Occurs in Antigen-Presenting Cells from AIDS-Susceptible but Not from AIDS-Resistant Species
Kim, N., Dabrowska, A., Jenner, R. G., & Aldovini, A. (2007) · Journal of Virology · doi:10.1128/jvi.02616-06 · Cited by 31
Interleukin 7 Increases Human Immunodeficiency Virus Type 1 LAI-Mediated Fas-Induced T-Cell Death
Lelièvre, J., Petit, F., Arnoult, D., Ameisen, J., & Estaquier, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.3195-3199.2005 · Cited by 30
T-CELL AND NEURONAL APOPTOSIS IN HIV INFECTION: IMPLICATIONS FOR THERAPEUTIC INTERVENTION
Régulier, E. G., K, R., Khalili, K., Amini, S., Rappaport, J., Zagury, J., & Katsikis, P. D. (2004) · International Reviews of Immunology · doi:10.1080/08830180490265538 · Cited by 30
Self-citation
TNF-α Controls Intrahepatic T Cell Apoptosis and Peripheral T Cell Numbers
Murray, D. A., & Crispe, I. N. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2402 · Cited by 29
Elite controller CD8+ T cells exhibit comparable viral inhibition capacity, but better sustained effector properties compared to chronic progressors
Shasha, D., Karel, D., Angiuli, O., Greenblatt, A., Ghebremichael, M. S., Yu, X. G., Porichis, F., & Walker, B. D. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4a0915-422r · Cited by 28
Apoptosis of HIV-specific CD8+ T cells: an HIV evasion strategy
Petrovas, C., Mueller, Y. M., & Katsikis, P. D. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401595 · Cited by 28
Self-citation
A novel mechanism for HIV1-mediated bystander CD4+ T-cell death: neighboring dying cells drive the capacity of HIV1 to kill noncycling primary CD4+ T cells
Lelièvre, J., Mammano, F., Arnoult, D., Petit, F., Grodet, A., Estaquier, J., & Ameisen, J. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401441 · Cited by 23
Phenotypic Characterization of HIV-Specific CD8+ T Cells during Early and Chronic Infant HIV-1 Infection
Slyker, J. A., John-Stewart, G. C., Dong, T., Lohman-Payne, B. L., Reilly, M., Atzberger, A., Taylor, S., Maleche‐Obimbo, E., Mbori‐Ngacha, D., & Rowland‐Jones, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020375 · Cited by 21
Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure
Viganó, S., Bobisse, S., Coukos, G., Perreau, M., & Harari, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01350 · Cited by 21
Insights Into the Pathophysiology of Liver Disease in HCV/HIV: Does it End With HCV Cure?
Jeyarajan, A. J., & Chung, R. T. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa279 · Cited by 20
Lipophagy confers a key metabolic advantage that ensures protective CD8A T-cell responses against HIV-1
Loucif, H., Dagenais-Lussier, X., Beji, C., Cassin, L., Jrade, H., Tellitchenko, R., Routy, J., Olagnier, D. P., & van Grevenynghe, J. (2021) · Autophagy · doi:10.1080/15548627.2021.1874134 · Cited by 21
Low-level HIV-1 viremia affects T-cell activation and senescence in long-term treated adults in the INSTI era
Lara‐Aguilar, V., Llamas-Adán, M., Brochado‐Kith, O., Crespo‐Bermejo, C., Grande‐García, S., Arca-Lafuente, S., Santos, I. D. L., PRADO, C. M. C. O., Alía, M., Sainz-Pinós, C., et al. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01064-z · Cited by 19
Reduction in terminally differentiated T cells in virologically controlled HIV-infected aging patients on long-term antiretroviral therapy
Behrens, N. E., Wertheimer, A. M., Klotz, S. A., & Ahmad, N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199101 · Cited by 16
HIV-Specific Cytotoxic Cell Frequencies Measured Directly Ex Vivo by the Lysispot Assay Can Be Higher or Lower Than the Frequencies of IFN-γ-Secreting Cells: Anti-HIV Cytotoxicity Is Not Generally Impaired Relative to Other Chronic Virus Responses
Snyder-Cappione, J. E., Divekar, A., Maupin, G. M., Jin, X., Demeter, L. M., & Mosmann, T. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2662 · Cited by 17
Expression of Interleukin-15 and Interleukin-15Rα in Monocytes of HIV Type 1-Infected Patients with Different Courses of Disease Progression
Tarkowski, M., Ferraris, L., Martone, S., de Castilla, F. S., Misciagna, D., Mazzucchelli, R. I., Lattuada, E., Paraninfo, G., Galli, M., & Riva, A. (2011) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2010.0317 · Cited by 17
Apoptosis of CD57+ and CD57− lymphocytes in the lung and blood of HIV-infected subjects
Wood, K. L., Knox, K. S., Wang, Y., Day, R. B., Schnizlein-Bick, C. T., & Twigg, H. L. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.09.009 · Cited by 17
Sanctuaire du virus de l’immunodéficience humaine et mécanismes d’échappement
Estaquier, J., & Hurtrel, B. (2008) · médecine/sciences · doi:10.1051/medsci/200824121055 · Cited by 18
Human immunodeficiency virus infection and acquired immunodeficiency syndrome dementia complex: Role of cells of monocyte-macrophage lineage
Aquaro, S., Ronga, L., Pollicita, M., Antinori, A., Ranazzi, A., & Perno, C. F. (2005) · Journal of NeuroVirology · doi:10.1080/13550280500513416 · Cited by 16

Authors: Mueller, Y. M., De Rosa, S. C., Hutton, J. A., Witek, J., Roederer, M., Altman, J. D., & Katsikis, P. D.
Affiliations: Hahnemann University Hospital (US)
National Institutes of Health (US)
Emory University (US)
Corresponding author: Katsikis, Peter D
ORCID: Mueller, Yvonne M
Witek, James
Roederer, Mario
Altman, John D
Katsikis, Peter D
Venue: Immunity
Publisher: Elsevier BV
Published: 2001-12
Volume: 15
Issue: 6
Pages: 871-882
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/s1074-7613(01)00246-1
OpenAlex: W2044870374
Cited by: 164
References: 48
Citations by year: 2026: 3 · 2025: 4 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 9 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 7 · 2013: 7 · 2012: 4
FWCI: 5.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4246 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01 AI46719, R01AI046719)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: HIV-specific CD8+ T cells, Fas ligand, T cell survival, T cell differentiation, effector memory T cells, CD45RA, L-selectin, cytotoxicity, IFN-gamma production, HIV infection, cytotoxic T lymphocytes
MeSH terms: Adult, Cell Differentiation, Cytomegalovirus, Cytotoxicity, Immunologic, Herpesvirus 4, Human, HIV, Humans, Immunologic Memory, Interferon-gamma, Macrophages, T-Lymphocytes, Cytotoxic, HIV Infections, Immunophenotyping, T-Lymphocyte Subsets, Apoptosis, Leukocyte Common Antigens, Coculture Techniques, fas Receptor, L-Selectin, Viral Load

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks