The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Cooperative and Antagonistic Interplay between PU.1 and GATA-2 in the Specification of Myeloid Cell Fates
Open accessAbstract
PU.1 and GATA transcription factors appear to antagonize each other's function in the development of distinct lineages of the hematopoietic system. In contrast, we demonstrate that PU.1, like GATA-2, is essential for the generation of mast cells. PU.1-/- hematopoietic progenitors can be propagated in IL-3 and differentiate into mast cells or macrophages upon restoration of PU.1 activity. Using these progenitors and a conditionally activatable PU.1 protein, we show that PU.1 can negatively regulate expression of the GATA-2 gene. In the absence of GATA-2, PU.1 promotes macrophage but not mast cell differentiation. Reexpression of GATA-2 in such progenitors enables the generation of mast cells. We propose a developmental model in which cooperative function or antagonistic crossregulation by PU.1 of GATA-2 promotes distinct myeloid cell fates.
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“These cells constitutively express a low level of PU.1 from the transgene, with 4-OHT rapidly inducing PU.1 protein activation (Walsh et al., 2002).”
From PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress (2021) · cites this paper as Walsh et al., 2002
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BackgroundPU.1, a Shared Transcriptional Regulator of Innate and Adaptive Immune Cell Fates
Singh, H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1595 · Cited by 7
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Long, T., Bhattacharyya, T., Repele, A., Naylor, M., Nooti, S. K., Krueger, S., & Manu (2023) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkad269 · Cited by 8
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“During hemin-induced differentiation, GATA-2 and PU.1 were predicted to act cooperatively in Day 3, consistent with reports in which their combination specifies mast cell fate in hematopoietic progenitors (Walsh et al., 2002).”
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“Interestingly, in MCs, GATA-1 and PU.1 cooperatively transactivate MC-specific gene regulation (Nishiyama et al. 2002), similarly to cooperation between GATA-2 and PU.1 ( Walsh et al. 2002 ).”
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“GATA2 and PU.1 can be antagonistic, and balancing their activities ensures normal hematopoiesis ( 26 , 27 ).”
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“Importantly, these factors are cross-antagonistic and the relative abundance of each reinforces bifurcating lineage decisions (Walsh et al., 2002).”
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“Walsh et al (2002) showed that PU.1 antagonized GATA-2 expression during macrophage differentiation, but functioned cooperatively with GATA-2 to specify the mast cell fate.”
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Ishii, K., Nagata, K., Yamashita, N., Yamazaki, Y., Akimoto, Y., Zhao, W., Inoue, M., Ito, N., Kasakura, K., & Nishiyama, C. (2025) · FEBS Journal · doi:10.1111/febs.70252 · Cited by 2
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“PU.1 / cells from mouse bone marrow carrying an Spi1 (PU.1) transgene fused to the ligand-binding domain of the estrogen receptor [PUER; 33] can be inducibly differentiated into macrophages or neutrophils in IL3 or GCSF respectively [Fig.”
Handzlik, J. E., & Manu (2021) · bioRxiv · doi:10.1101/2021.05.10.443501
“…that Spi1 knockout mice lack mature white-blood cells [38] and that their bone marrow contains IL3-dependent granulocyte-monocyte progenitors (GMPs) [43, 44], while disruption of Spi1 in mouse granulocyte/monocyte-committed progenitors prevents their maturation but not proliferation [45].”
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“…factor SPI1 was demonstrated in SPI1 knockout mice to be necessary for the development of B cells, T cells, neutrophils, macrophages, dendritic cells, and mast cells (Anderson et al. 2000; Guerriero et al. 2000; McKercher et al. 1996; Scott et al. 1994; Scott et al. 1997; Walsh et al. 2002).”
BackgroundEstablishment of a Screening System to Identify Novel GATA-2 Transcriptional Regulators.
Ohashi, K., Fujiwara, T., Onodera, K., Saito, Y., Ichikawa, S., Kobayashi, M., Okitsu, Y., Fukuhara, N., Onishi, Y., & Harigae, H. (2018) · Tohoku journal of experimental medicine · doi:10.1620/tjem.244.41
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BackgroundTang, M. S., Miraldi, E. R., Girgis, N. M., Bonneau, R., & Loke, P. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/327023
“1 is better characterized as a pioneer factor that shapes the chromatin landscape during macrophage development (14, 15), it can also unveil latent enhancers during macrophage activation, through cooperative binding with”
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“1 est un facteur de transcription requis pour le développement des mastocytes in vitro et in vivo mais il n’apparaît pas spécifique aux mastocytes car ce facteur est aussi important pour la lignée lymphoïde, les mégacaryocytes et érythroblastes [63].”
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Leukemia stem cell fates are determined by DNA methylation levels
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“, 2002) and can negatively regulate expression of the GATA-2 gene, thereby promoting distinct myeloid cell fates (Walsh et al., 2002).”
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Metadata
- Authors
- Walsh, J. C., DeKoter, R. P., Lee, H.-J., Smith, E. D., Lancki, D. W., Gurish, M. F., Friend, D. S., Stevens, R. L., Anastasi, J., & Singh, H.
- Affiliations
- University of Chicago (US)
- Howard Hughes Medical Institute (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Singh, Harinder
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 17
- Issue
- 5
- Pages
- 665-676
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2145064410
- Cited by
- 262
- References
- 0
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 10 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 11 · 2015: 16 · 2014: 18 · 2013: 8 · 2012: 11
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL07237, HL-36110, P01HL036110)
- National Institute of General Medical Sciences (GM07151, T32GM007151)
- National Institute of Allergy and Infectious Diseases (AI-23483, AI31599, R01AI023483)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- PU.1, GATA2, mast cell differentiation, macrophage differentiation, hematopoietic progenitor cells, transcription factors
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, DNA-Binding Proteins, Macrophages, Mast Cells, Proto-Oncogene Proteins, Transcription Factors, Trans-Activators, Zinc Fingers, Gene Expression Regulation, Developmental, Cell Lineage, Myelopoiesis, GATA2 Transcription Factor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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