The DOI matches its Crossref record.
Activation-Induced Polarized Recycling Targets T Cell Antigen Receptors to the Immunological Synapse
Open accessAbstract
The mechanism by which T cell antigen receptors (TCR) accumulate at the immunological synapse has not been fully elucidated. Since TCRs are continuously internalized and recycled back to the cell surface, we investigated the role of polarized recycling in TCR targeting to the immunological synapse. We show here that the recycling endosomal compartment of T cells encountering activatory antigen-presenting cells (APCs) polarizes towards the T cell-APC contact site. Moreover, TCRs in transit through recycling endosomes are targeted to the immunological synapse. Inhibition of T cell polarity, constitutive TCR endocytosis, or recycling reduces TCR accumulation at the immunological synapse. Conversely, increasing the amount of TCRs in recycling endosomes before synapse formation enhanced their accumulation. Finally, we show that exocytic t-SNAREs from T cells cluster at the APC contact site and that tetanus toxin inhibits TCR accumulation at the immunological synapse, indicating that vesicle fusion mediated by SNARE complexes is involved in TCR targeting to the immunological synapse.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Dustin, M. L. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0161 · Cited by 502
Virus cell-to-cell transmission
Mothes, W., Sherer, N. M., Jin, J., & Zhong, P. (2010) · Journal of Virology · doi:10.1128/jvi.00443-10 · Cited by 353
Tuning immune responses: diversity and adaptation of the immunological synapse
Friedl, P., den Boer, A. T., & Gunzer, M. (2005) · Nature Reviews Immunology · doi:10.1038/nri1647 · Cited by 276
SNAREing immunity: the role of SNAREs in the immune system
Stow, J. L., Manderson, A. P., & Murray, R. Z. (2006) · Nature Reviews Immunology · doi:10.1038/nri1980 · Cited by 235
Immunological synapse and microclusters: the site for recognition and activation of T cells
Saito, T., & Yokosuka, T. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.014 · Cited by 124
Metadata
- Authors
- Das, V., Nal, B., Dujeancourt, A., Thoulouze, M.-I., Galli, T., Roux, P., Dautry-Varsat, A., & Alcover, A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 20
- Issue
- 5
- Pages
- 577-588
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2008602824
- Cited by
- 294
- References
- 0
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Activation-Induced Polarized Recycling Targets T Cell Antigen Receptors to the Immunological Synapse. https://app.cochat.ai/papers/10.1016/s1074-7613(04)00106-2
- The paper
- Das, V., Nal, B., Dujeancourt, A., Thoulouze, M.-I., Galli, T., Roux, P., Dautry-Varsat, A., & Alcover, A. (2004). Activation-Induced Polarized Recycling Targets T Cell Antigen Receptors to the Immunological Synapse. Immunity. https://doi.org/10.1016/s1074-7613(04)00106-2
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
