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Activation-Induced Polarized Recycling Targets T Cell Antigen Receptors to the Immunological Synapse
Open accessAbstract
The mechanism by which T cell antigen receptors (TCR) accumulate at the immunological synapse has not been fully elucidated. Since TCRs are continuously internalized and recycled back to the cell surface, we investigated the role of polarized recycling in TCR targeting to the immunological synapse. We show here that the recycling endosomal compartment of T cells encountering activatory antigen-presenting cells (APCs) polarizes towards the T cell-APC contact site. Moreover, TCRs in transit through recycling endosomes are targeted to the immunological synapse. Inhibition of T cell polarity, constitutive TCR endocytosis, or recycling reduces TCR accumulation at the immunological synapse. Conversely, increasing the amount of TCRs in recycling endosomes before synapse formation enhanced their accumulation. Finally, we show that exocytic t-SNAREs from T cells cluster at the APC contact site and that tetanus toxin inhibits TCR accumulation at the immunological synapse, indicating that vesicle fusion mediated by SNARE complexes is involved in TCR targeting to the immunological synapse.
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Citations
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Piotrowski, J. T., Gomez, T. S., Schoon, R. A., Mangalam, A. K., & Billadeau, D. D. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01288-12 · Cited by 101
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SNX17 Affects T Cell Activation by Regulating TCR and Integrin Recycling
Osborne, D. G., Piotrowski, J. T., Dick, C. J., Zhang, J.-S., & Billadeau, D. D. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402734 · Cited by 50
Metadata
- Authors
- Das, V., Nal, B., Dujeancourt, A., Thoulouze, M.-I., Galli, T., Roux, P., Dautry-Varsat, A., & Alcover, A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 20
- Issue
- 5
- Pages
- 577-588
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2008602824
- Cited by
- 294
- References
- 0
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
