Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate

Slaven, John W; Anderson, Michael J; Sanglard, Dominique; Dixon, Graham K; Bille, Jacques; Roberts, Ian S; Denning, David W

doi:10.1016/s1087-1845(02)00016-6

Cited by 202Antifungal resistance and susceptibilityFungal and yeast genetics researchDrug Transport and Resistance Mechanisms

Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate

Slaven, John W, Anderson, Michael J, Sanglard, Dominique, Dixon, Graham K, Bille, Jacques, Roberts, Ian S, Denning, David W·2002·Fungal Genetics and Biology

DOI 10.1016/s1087-1845(02)00016-6

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Abstract

Aspergillus fumigatus is the most frequent causative agent of invasive aspergillosis. Itraconazole became available in 1990 to treat invasive aspergillosis, but instances of resistance have now been described. Drug efflux was a proposed mechanism in one itraconazole resistant clinical isolate (AF72) which accumulates low levels of the drug. Drug efflux in fungi can be mediated by ATP-binding cassette transporter (ABCT) genes, such as CDR1 in Candida albicans. Using a probe derived from CDR1, a gene, atrF, was cloned from A. fumigatus. The atrF gene product (AtrF) is 1547 amino acids long and has characteristic multidrug resistance motifs. Dot blot analysis revealed that AF72 has approximately 5-fold higher levels of atrF mRNA than susceptible isolates AF10 and H06-03 in cultures with sub-minimum inhibitory concentration (sub-MIC) levels of itraconazole. atrF is the first ABCT gene cloned from A. fumigatus, whose overexpression is correlated with itraconazole resistance.

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Overexpression of multidrug efflux transporters mediates azole resistance in other fungal pathogens, with the major players being ABC transporters Afr1 and AtrF for C. neoformans and A. fumigatus, respectively.
“Overexpression of multidrug efflux transporters also mediates azole resistance in other fungal pathogens, with the major players being the ABC transporters Afr1 and AtrF for C. neoformans and A. fumigatus, respectively60,61.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [60]

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
Welsh, M. J., & Smith, A. E. (1993) · Cell · doi:10.1016/0092-8674(93)90353-r · Cited by 1,485 · see citing works
Clinical, Cellular, and Molecular Factors That Contribute to Antifungal Drug Resistance
White, T. C., Marr, K. A., & Bowden, R. A. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.2.382 · Cited by 1,353 · see citing works
Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
Sanglard, D., Kuchler, K., Ischer, F., Pagani, J. L., Monod, M., & Bille, J. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.11.2378 · Cited by 815 · see citing works
Self-citation
Trends in the postmortem epidemiology of invasive fungal infections at a University Hospital
Groll, A. H., Shah, P. M., MENTZEL, C., Schneider, M., Just‐Nübling, G., & Huebner, K. (1996) · Journal of Infection · doi:10.1016/s0163-4453(96)92700-0 · Cited by 779 · see citing works
Therapeutic Outcome in Invasive Aspergillosis
Denning, D. W. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/23.3.608 · Cited by 694 · see citing works
Self-citation
Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
White, T. C. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.7.1482 · Cited by 612 · see citing works
Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene
Sanglard, D., Ischer, F., Monod, M., & Bille, J. (1997) · Microbiology · doi:10.1099/00221287-143-2-405 · Cited by 587 · see citing works
Self-citation
Itraconazole resistance in Aspergillus fumigatus
Denning, D. W., Venkateswarlu, K., Oakley, K. L., Anderson, M. J., Manning, N. J., Stevens, D. A., Warnock, D. W., & Kelly, S. L. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.6.1364 · Cited by 507 · see citing works
Self-citation
Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
Prasad, R., De Wergifosse, P., Goffeau, A., & Balzi, E. (1995) · Current Genetics · doi:10.1007/bf00352101 · Cited by 486 · see citing works
Gene Structure in Eukaryotic Microbes
Kinghorn, J. R. (1987) · Medical Entomology and Zoology · Cited by 470 · see citing works
Prevalence of Molecular Mechanisms of Resistance to Azole Antifungal Agents in Candida albicans Strains Displaying High-Level Fluconazole Resistance Isolated from Human Immunodeficiency Virus-Infected Patients
Perea, S., López-Ribot, J. L., Kirkpatrick, W. R., McAtee, R. K., Santillán, R. A., Martı́nez, M., Calabrese, D., Sanglard, D., & Patterson, T. F. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.10.2676-2684.2001 · Cited by 470 · see citing works
Self-citation
Complete inventory of the yeast ABC proteins
Decottignies, A., & Goffeau, A. (1997) · Nature Genetics · doi:10.1038/ng0297-137 · Cited by 455 · see citing works
PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.
Balzi, E., Wang, M., Leterme, S., Van Dyck, L., & Goffeau, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42155-7 · Cited by 447 · see citing works
Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
Sanglard, D., Ischer, F., Monod, M., & Billé, J. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.10.2300 · Cited by 402 · see citing works
Self-citation
A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein
Cutting, G. R., Kasch, L. M., Rosenstein, B. J., Zielenski, J., Tsui, L., Antonarakis, S. E., & Kazazian, H. H. (1990) · Nature · doi:10.1038/346366a0 · Cited by 397 · see citing works
Anticancer Drugs, Ionophoric Peptides, and Steroids as Substrates of the Yeast Multidrug Transporter Pdr5p
Kołaczkowski, M., Michel, V. D. R., Cybularz-Kolaczkowska, A., Soumillion, J., Konings, W. N., & Goffeau, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31543 · Cited by 323 · see citing works
Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance
BAUER, B. E., Wolfger, H., & Kuchler, K. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00160-1 · Cited by 278 · see citing works
Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome of Aspergillus fumigatus infection
Denning, D. W. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/40.3.401 · Cited by 234 · see citing works
Self-citation
Distinct Patterns of Gene Expression Associated with Development of Fluconazole Resistance in Serial Candida albicans Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis
Lopez-Ribot, J. L., McAtee, R. K., Lee, L. N., Kirkpatrick, W. R., White, T. C., Sanglard, D., & Patterson, T. F. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.11.2932 · Cited by 210 · see citing works
Self-citation
Gene SNQ2 of Saccharomyces cerevislae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases
Servos, J., Haase, E., & Brendel, M. (1993) · Molecular and General Genetics MGG · doi:10.1007/bf00277115 · Cited by 203 · see citing works
A Novel ATP-Binding Cassette Transporter Involved in Multidrug Resistance in the Phytopathogenic Fungus Penicillium digitatum
Nakaune, R., Adachi, K., Nawata, O., Tomiyama, M., AKUTSU, K., & Hibi, T. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3983-3988.1998 · Cited by 197 · see citing works
Functional Expression of Candida albicans Drug Efflux Pump Cdr1p in a Saccharomyces cerevisiae Strain Deficient in Membrane Transporters
Nakamura, K., Niimi, M., Niimi, K., Holmes, A. R., Yates, J. E., Decottignies, A., Monk, B. C., Goffeau, A., & Cannon, R. D. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.12.3366-3374.2001 · Cited by 185 · see citing works
Rapid, Transient Fluconazole Resistance in Candida albicans Is Associated with Increased mRNA Levels of CDR
Marr, K. A., Lyons, C. N., Rustad, T., Bowden, R. A., & White, T. C. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.10.2584 · Cited by 166 · see citing works
Fluconazole Resistance Associated with Drug Efflux and Increased Transcription of a Drug Transporter Gene, PDH1 , in Candida glabrata
Miyazaki, H., Miyazaki, Y., Geber, A., Parkinson, T., Hitchcock, C. A., Falconer, D. J., Ward, D. J., Marsden, K. E., & Bennett, J. E. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.7.1695 · Cited by 162 · see citing works
Genetic Separation of FK506 Susceptibility and Drug Transport in the Yeast Pdr5 ATP-binding Cassette Multidrug Resistance Transporter
Egner, R., Rosenthal, F. E., Kralli, A., Sanglard, D., & Kuchler, K. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.2.523 · Cited by 153 · see citing works
Self-citation
Altered Drug-stimulated ATPase Activity in Mutants of the Human Multidrug Resistance Protein
Müller, M., Bakos, É., Welker, E., Váradi, A., Germann, U. A., Gottesman, M. M., Morse, B. S., Roninson, I. B., & Sarkadi, B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.4.1877 · Cited by 150 · see citing works
Acquired itraconazole resistance in Aspergillus fumigatus
Dannaoui, É. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/47.3.333 · Cited by 145 · see citing works
Multidrug resistance in Aspergillus nidulans involves novel ATP-binding cassette transporters
Sorbo, G. D., Andrade, A. C., van Nistelrooy, J. G. M., van Kan, J. A. L., Balzi, E., & Waard, M. A. D. (1997) · Molecular and General Genetics MGG · doi:10.1007/s004380050434 · Cited by 137 · see citing works
The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds
Andrade, A. C., Sorbo, G. D., van Nistelrooy, J. G. M., & Waard, M. A. D. (2000) · Microbiology · doi:10.1099/00221287-146-8-1987 · Cited by 132 · see citing works
Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus
Tobin, M. B., Peery, R. B., & Skatrud, P. L. (1997) · Gene · doi:10.1016/s0378-1119(97)00281-3 · Cited by 129 · see citing works
Restriction Endonuclease Analysis of Total Cellular DNA of Aspergillus fumigatus Isolates of Geographically and Epidemiologically Diverse Origin
Denning, D. W., Clemons, K. V., Hanson, L. H., & Stevens, D. A. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/162.5.1151 · Cited by 128 · see citing works
Self-citation
The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production
Andrade, A. C., van Nistelrooy, J. G. M., Peery, R. B., Skatrud, P. L., & Waard, M. A. D. (2000) · Molecular and General Genetics MGG · doi:10.1007/pl00008697 · Cited by 126 · see citing works
Azole Cross-Resistance in Aspergillus fumigatus
Mosquera, J., & Denning, D. W. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.2.556-557.2002 · Cited by 122 · see citing works
Self-citation
Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease of Aspergillus fumigatus
Jaton‐Ogay, K., Suter, M., Crameri, R., Falchetto, R., Fatih, A., & Monod, M. (1992) · FEMS Microbiology Letters · doi:10.1016/0378-1097(92)90506-j · Cited by 120 · see citing works
In Vitro Susceptibility of Respiratory Isolates of Aspergillus species to Itraconazole and Amphotericin B. Acquired Resistance to Itraconazole
Chryssanthou, E. (1997) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365549709011864 · Cited by 105 · see citing works
Identification and expression of multidrug resistancerelated ABC transporter genes in Candida krusei
Katiyar, S. K., & Edlind, T. D. (2001) · Medical Mycology · doi:10.1080/mmy.39.1.109.116 · Cited by 104 · see citing works
[10] Saccharomyces cerevisiae ABC proteins and their relevance to human health and disease
Taglicht, D., & Michaelis, S. (1998) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(98)92012-2 · Cited by 101 · see citing works
Molecular typing by random amplification of polymorphic DNA and M13 southern hybridization of related paired isolates of Aspergillus fumigatus
Anderson, M. J., Gull, K., & Denning, D. W. (1996) · Journal of Clinical Microbiology · doi:10.1128/jcm.34.1.87-93.1996 · Cited by 86 · see citing works
Self-citation
In-vitro susceptibility of Aspergillus spp. isolates to amphotericin B and itraconazole
Dannaoui, É., Persat, F., Monier, M., Borel, E., Piens, M., & Picot, S. (1999) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/44.4.553 · Cited by 83 · see citing works
Transcriptional Analyses of Antifungal Drug Resistance in Candida albicans
Lyons, C. N., & White, T. C. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.9.2296-2303.2000 · Cited by 79 · see citing works
Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease ofAspergillus fumigatus
Jaton‐Ogay, K., Suter, M., Crameri, R., et al. (1992) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1992.tb05253.x · Cited by 73 · see citing works
Reduced susceptibility in laboratory-selected mutants of Aspergillus fumigatus to itraconazole due to decreased intracellular accumulation of the antifungal agent
Manavathu, E. K., Vázquez, J. A., & Chandrasekar, P. H. (1999) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(98)00102-2 · Cited by 60 · see citing works
A Four-Year Review of Fatal Aspergillosis
Vogeser, M., Wanders, A., Haas, A., & Ruckdeschel, G. (1999) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s100960050224 · Cited by 53 · see citing works
In-vivo itraconazole resistance of Aspergillus fumigatus in systemic murine aspergillosis
Dannaoui, É., Borel, E., Persat, F., Monier, M., Piens, M. A., & Ebga Network (1999) · Journal of Medical Microbiology · doi:10.1099/00222615-48-12-1087 · Cited by 47 · see citing works
Expression of atrC – encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans – is sensitive to cycloheximide1The sequence of atrC has been deposited in GenBank under the accession number AF082072.1
Angermayr, K., Parson, W., Stöffler, G., & Haas, H. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(98)00107-0 · Cited by 26 · see citing works

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Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw326 · Cited by 2,926 · see citing works
Self-citation
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Cowen, L. E., Sanglard, D., Howard, S. J., Rogers, P. D., & Perlin, D. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019752 · Cited by 647 · see citing works
Self-citation
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Kanafani, Z. A., & Perfect, J. R. (2008) · Clinical Infectious Diseases · doi:10.1086/524071 · Cited by 619 · see citing works
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Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., Tanabe, K., Niimi, M., Goffeau, A., & Monk, B. C. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00051-08 · Cited by 608 · see citing works
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Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00045-10 · Cited by 576 · see citing works
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Revie, N. M., Iyer, K. R., Robbins, N., & Cowen, L. E. (2018) · Current Opinion in Microbiology · doi:10.1016/j.mib.2018.02.005 · Cited by 528 · see citing works
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Vandeputte, P., Ferrari, S., & Coste, A. T. (2011) · International Journal of Microbiology · doi:10.1155/2012/713687 · Cited by 507 · see citing works
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Mellado, E., Garcia-Effron, G., Alcázar-Fuoli, L., Melchers, W. J. G., Verweij, P. E., Cuenca-Estrella, M., & Rodríguez-Tudela, J. L. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01092-06 · Cited by 490 · see citing works
Emerging Threats in Antifungal-Resistant Fungal Pathogens
Sanglard, D. (2016) · Frontiers in Medicine · doi:10.3389/fmed.2016.00011 · Cited by 420 · see citing works
Self-citation
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Scorzoni, L., de Paula e Silva, A. C. A., Marcos, C. M., Assato, P. A., de Melo, W. C. M. A., de Oliveira, H. C., Costa-Orlandi, C. B., Mendes-Giannini, M. J. S., & Fusco-Almeida, A. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00036 · Cited by 418 · see citing works
What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis
Abad, A., Fernandez-Molina, J. V., Bikandi, J., Ramirez‐Garcia, A., Margareto, J., Sendino, J., Hernando, F. L., Pontón, J., Garaizar, J., & Rementerı́a, A. (2010) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2010.10.003 · Cited by 394 · see citing works
Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009
Bueid, A. S., Howard, S. J., Moore, C. B., Richardson, M. D., Harrison, E., Bowyer, P., & Denning, D. W. (2010) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq279 · Cited by 333 · see citing works
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Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.
Cowen, L. E., & Steinbach, W. J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00041-08 · Cited by 285 · see citing works
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Self-citation
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Aspergillus fumigatus and aspergillosis: From basics to clinics
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Chen, J., Li, H., Li, R., Bu, D., & Wan, Z. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh507 · Cited by 196 · see citing works
Ergosterol biosynthesis in Aspergillus fumigatus: its relevance as an antifungal target and role in antifungal drug resistance
Alcázar‐Fuoli, L., & Mellado, E. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00439 · Cited by 187 · see citing works
Multidrug Resistance in Fungi
Gulshan, K., & Moye-Rowley, S. (2007) · Eukaryotic Cell · doi:10.1128/ec.00254-07 · Cited by 184 · see citing works
Multidrug Resistance in Yeast Candida
Prasad, R., & Kapoor, K. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)42005-1 · Cited by 182 · see citing works
Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus
Gonçalves, S. S., Souza, A. C. R., Chowdhary, A., Meis, J. F. G. M., & Colombo, A. L. (2016) · Mycoses · doi:10.1111/myc.12469 · Cited by 182 · see citing works
Resistance of human fungal pathogens to antifungal drugs
Sanglard, D. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00344-2 · Cited by 178 · see citing works
Self-citation
Azole resistance mechanisms in Aspergillus: update and recent advances
Pérez‐Cantero, A., López‐Fernández, L., Guarro, J., & Capilla, J. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.09.011 · Cited by 175 · see citing works
Update on Antifungal Drug Resistance
Perlin, D. S., Shor, E., & Zhao, Y. (2015) · Current Clinical Microbiology Reports · doi:10.1007/s40588-015-0015-1 · Cited by 174 · see citing works
Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole
Ferreira, M. E. D. S., Malavazi, I., Savoldi, M., Brakhage, A. A., Goldman, M. H. S., Kim, H. S., Nierman, W. C., & Goldman, G. H. (2006) · Current Genetics · doi:10.1007/s00294-006-0073-2 · Cited by 159 · see citing works
The ergosterol biosynthesis pathway, transporter genes, and azole resistance inAspergillus fumigatus
Da Silva Ferreira, M. E., Colombo, A. L., Paulsen, I., Ren, Q., Wortman, J., Huang, J., Goldman, M. H. S., & Goldman, G. H. (2005) · Medical Mycology · doi:10.1080/13693780400029114 · Cited by 158 · see citing works
A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions
Hagiwara, D., Miura, D., Shimizu, K., Paul, S., Ohba, A., Gonoi, T., Watanabe, A., Kamei, K., Shintani, T., Moye-Rowley, W. S., et al. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006096 · Cited by 156 · see citing works
Triazole Resistance in Aspergillus Species: An Emerging Problem
Garcia‐Rubio, R., Cuenca‐Estrella, M., & Mellado, E. (2017) · Drugs · doi:10.1007/s40265-017-0714-4 · Cited by 155 · see citing works
In Vitro Evolution of Itraconazole Resistance in Aspergillus fumigatus Involves Multiple Mechanisms of Resistance
Ferreira, M. E. D. S., Capellaro, J. L., Marques, E. D. R., Malavazi, I., Perlin, D. S., Park, S., Anderson, J. B., Colombo, A. L., Arthington, B. A., Goldman, M. H. S., et al. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.11.4405-4413.2004 · Cited by 147 · see citing works
Triazole Resistance in Aspergillus spp.: A Worldwide Problem?
Rivero-Menendez, O., Alastruey-Izquierdo, A., Mellado, E., & Cuenca-Estrella, M. (2016) · Journal of Fungi · doi:10.3390/jof2030021 · Cited by 142 · see citing works
Multidrug resistance in fungi: regulation of transporter-encoding gene expression
Paul, S., & Moye-Rowley, W. S. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00143 · Cited by 137 · see citing works
Update on antifungal drug resistance mechanisms of Aspergillus fumigatus
Chamilos, G., & Kontoyiannis, D. P. (2005) · Drug Resistance Updates · doi:10.1016/j.drup.2006.01.001 · Cited by 137 · see citing works
Exploring Azole Antifungal Drug Resistance in Aspergillus fumigatus with Special Reference to Resistance Mechanisms
Chowdhary, A., Sharma, C., Hagen, F., & Meis, J. F. G. M. (2014) · Future Microbiology · doi:10.2217/fmb.14.27 · Cited by 132 · see citing works
cyp51A -Based Mechanisms of Aspergillus fumigatus Azole Drug Resistance Present in Clinical Samples from Germany
Bader, O., Weig, M., Reichard, U., Lugert, R., Kuhns, M., Christner, M., Held, J., Peter, S., Schumacher, U., Buchheidt, D., et al. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00167-13 · Cited by 129 · see citing works
Biofilm formation byAspergillus fumigatus
Kaur, S., & Singh, S. (2013) · Medical Mycology · doi:10.3109/13693786.2013.819592 · Cited by 128 · see citing works
Antifungal drug resistance mechanisms
Pemán, J., Cantón, E., & Espinel‐Ingroff, A. (2009) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.09.18 · Cited by 121 · see citing works
Global Transcriptome Changes Underlying Colony Growth in the Opportunistic Human Pathogen Aspergillus fumigatus
Gibbons, J. G., Beauvais, A., Beau, R., McGary, K. L., Latgé, J., & Rokas, A. (2011) · Eukaryotic Cell · doi:10.1128/ec.05102-11 · Cited by 115 · see citing works
Essential Letters in the Fungal Alphabet
Perlin, M. H., Andrews, J. M., & Toh, S. S. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800271-1.00004-4 · Cited by 110 · see citing works
Drug Strategies Targeting CYP51 in Neglected Tropical Diseases
Choi, J. Y., Podust, L. M., & Roush, W. R. (2014) · Chemical Reviews · doi:10.1021/cr5003134 · Cited by 110 · see citing works
Rapid Detection of Triazole Antifungal Resistance in Aspergillus fumigatus
García‐Effrón, G., Dilger, A., Alcázar‐Fuoli, L., Park, S., Mellado, E., & Perlin, D. S. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.02330-07 · Cited by 102 · see citing works
Elucidating Drug Resistance in Human Fungal Pathogens
Xie, J. L., Polvi, E. J., Shekhar‐Guturja, T., & Cowen, L. E. (2014) · Future Microbiology · doi:10.2217/fmb.14.18 · Cited by 98 · see citing works
Azole Resistance In Aspergillus Fumigatus : A New Challenge In The Management Of Invasive Aspergillosis?
Snelders, E., Melchers, W. J. G., & Verweij, P. E. (2011) · Future Microbiology · doi:10.2217/fmb.11.4 · Cited by 96 · see citing works
Interrogation of Related Clinical Pan-Azole-Resistant Aspergillus fumigatus Strains: G138C, Y431C, and G434C Single Nucleotide Polymorphisms incyp51A, Upregulation ofcyp51A, and Integration and Activation of TransposonAtf1in thecyp51APromoter
Albarrag, A., Anderson, M. J., Howard, S. J., Robson, G., Warn, P. A., Sanglard, D., & Denning, D. W. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00517-11 · Cited by 94 · see citing works
Self-citation
Use of Epidemiological Cutoff Values To Examine 9-Year Trends in Susceptibility of Aspergillus Species to the Triazoles
Pfaller, M., Boyken, L., Hollis, R., Kroeger, J., Messer, S., Tendolkar, S., & Diekema, D. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.02136-10 · Cited by 91 · see citing works
An update on ABC transporters of filamentous fungi – from physiological substrates to xenobiotics
Víglaš, J., & Olejníková, P. (2021) · Microbiological Research · doi:10.1016/j.micres.2020.126684 · Cited by 91 · see citing works
Contributions of Aspergillus fumigatus ATP-Binding Cassette Transporter Proteins to Drug Resistance and Virulence
Paul, S. K., Diekema, D. J., & Moye-Rowley, S. (2013) · Eukaryotic Cell · doi:10.1128/ec.00171-13 · Cited by 91 · see citing works
Azole resistant Aspergillus fumigatus: An emerging problem
Lelièvre, L., Groh, M., Angebault, C., Maherault, A.-C., Didier, E., & Bougnoux, M. (2013) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2013.02.010 · Cited by 90 · see citing works
Passive Surveillance for Azole-ResistantAspergillus fumigatus, United States, 2011–2013
Pham, C. D., Reiss, E., Hagen, F., Meis, J. F. G. M., & Lockhart, S. R. (2014) · Emerging infectious diseases · doi:10.3201/eid2009.140142 · Cited by 88 · see citing works
Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance
Li, Y., Zhang, Y., Zhang, C., Wang, H., Wei, X., Chen, P., & Lü, L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911560116 · Cited by 87 · see citing works
Antifungal Susceptibilities of Aspergillus fumigatus Clinical Isolates Obtained in Nagasaki, Japan
Tashiro, M., Izumikawa, K., Minematsu, A., Hirano, K., Iwanaga, N., Ide, S., Mihara, T., Hosogaya, N., Takazono, T., Morinaga, Y., et al. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05394-11 · Cited by 87 · see citing works
Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical implications
Rogers, T. R., Verweij, P. E., Castanheira, M., Dannaoui, E., White, P. L., Arendrup, M. C., Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST), Arendrup, M. C., Arikan-Akdagli, S., Barchiesi, F., et al. (2022) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkac161 · Cited by 82 · see citing works
Concentration of Antifungal Agents within Host Cell Membranes: a New Paradigm Governing the Efficacy of Prophylaxis
Campoli, P., Abdallah, Q. A., Robitaille, R., Solis, N. V., Fielhaber, J. A., Kristof, A. S., Laverdière, M., Filler, S. G., & Sheppard, D. C. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00637-11 · Cited by 77 · see citing works
Identification of Aspergillus fumigatus multidrug transporter genes and their potential involvement in antifungal resistance
Meneau, I., Coste, A. T., & Sanglard, D. (2016) · Medical Mycology · doi:10.1093/mmy/myw005 · Cited by 75 · see citing works
Self-citation
In-host microevolution of Aspergillus fumigatus: A phenotypic and genotypic analysis
Ballard, E., Melchers, W. J. G., Zoll, J., Brown, A. J. P., Verweij, P. E., & Warris, A. (2018) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2018.02.003 · Cited by 75 · see citing works
Mechanisms of triazole resistance in Aspergillus fumigatus
Nywening, A. V., Rybak, J. M., Rogers, P. D., & Fortwendel, J. R. (2020) · Environmental Microbiology · doi:10.1111/1462-2920.15274 · Cited by 74 · see citing works
High prevalence of clinical and environmental triazole-resistant Aspergillus fumigatus in Iran: is it a challenging issue?
Nabili, M., Shokohi, T., Moazeni, M., Khodavaisy, S., Aliyali, M., Badiee, P., Zarrinfar, H., Hagen, F., & Badali, H. (2016) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000255 · Cited by 74 · see citing works
Combined Activity In Vitro of Caspofungin, Amphotericin B, and Azole Agents against Itraconazole-Resistant Clinical Isolates of Aspergillus fumigatus
Cuenca‐Estrella, M., Gómez‐López, A., García‐Effrón, G., Alcázar‐Fuoli, L., Mellado, E., Buitrago, M. J., & Rodrı́guez-Tudela, J. L. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.3.1232-1235.2005 · Cited by 71 · see citing works
Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates
Dilmaghanian, S., Gerber, J. G., Filler, S. G., Sanchez, A. A., & Gal, J. (2003) · Chirality · doi:10.1002/chir.10294 · Cited by 69 · see citing works
Aspergillosis, Avian Species and the One Health Perspective: The Possible Importance of Birds in Azole Resistance
Melo, A. M., Stevens, D. A., Tell, L. A., Veríssimo, C., Sabino, R., & Xavier, M. O. (2020) · Microorganisms · doi:10.3390/microorganisms8122037 · Cited by 68 · see citing works
Azole-Resistant Invasive Aspergillosis: Relationship to Agriculture
Stensvold, C. R., Jørgensen, L. N., & Arendrup, M. C. (2012) · Current Fungal Infection Reports · doi:10.1007/s12281-012-0097-7 · Cited by 67 · see citing works
Medically Important Fungi Respond to Azole Drugs: An Update
Zavřel, M., & White, T. C. (2015) · Future Microbiology · doi:10.2217/fmb.15.47 · Cited by 64 · see citing works
Does agricultural use of azole fungicides contribute to resistance in the human pathogen Aspergillus fumigatus ?
Hollomon, D. (2017) · Pest Management Science · doi:10.1002/ps.4607 · Cited by 57 · see citing works
Aspergillus fumigatus C-5 Sterol Desaturases Erg3A and Erg3B: Role in Sterol Biosynthesis and Antifungal Drug Susceptibility
Alcázar‐Fuoli, L., Mellado, E., García‐Effrón, G., Buitrago, M. J., López, J. F., Grimalt, J. O., Cuenca-Estrella, J. M., & Rodrı́guez-Tudela, J. L. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.2.453-460.2006 · Cited by 57 · see citing works
Cholesterol Import by Aspergillus fumigatus and Its Influence on Antifungal Potency of Sterol Biosynthesis Inhibitors
Xiong, Q., Hassan, S. A., Wilson, W. K., Han, X. Y., May, G. S., Tarrand, J. J., & Matsuda, S. P. T. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.518-524.2005 · Cited by 55 · see citing works
Genome‐wide identification of target genes of a mating‐type α‐domain transcription factor reveals functions beyond sexual development
Becker, K., Beer, C., Freitag, M., & Kück, U. (2015) · Molecular Microbiology · doi:10.1111/mmi.12987 · Cited by 54 · see citing works
Genomic perspective of triazole resistance in clinical and environmental Aspergillus fumigatus isolates without cyp51A mutations
Sharma, C., Sathi, S. N., Singh, A. K., Pillai, M. R., & Chowdhary, A. (2019) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2019.103265 · Cited by 54 · see citing works
Transcriptomic and Proteomic Profile of Aspergillus fumigatus on Exposure to Artemisinin
Gautam, P., Upadhyay, S. K., Hassan, W., Madan, T., Sirdeshmukh, R., Sundaram, C. S., Gade, W. N., Basir, S. F., Singh, Y. P., & Sarma, P. U. (2011) · Mycopathologia · doi:10.1007/s11046-011-9445-3 · Cited by 53 · see citing works
Pharmacology and clinical use of voriconazole
Thompson, G. R., & Lewis, J. S. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903463878 · Cited by 52 · see citing works
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Perlin, D. S., & Wiederhold, N. P. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix121 · Cited by 50 · see citing works
Analysis of a nonribosomal peptide synthetase gene from Alternaria brassicae and flanking genomic sequences
Guillemette, T., Sellam, A., & Simoneau, P. (2004) · Current Genetics · doi:10.1007/s00294-003-0479-z · Cited by 49 · see citing works
Multiple mechanisms contribute to the development of clinically significant azole resistance in Aspergillus fumigatus
Moye-Rowley, S. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00070 · Cited by 47 · see citing works
Prevalence, mechanisms and genetic relatedness of the human pathogenic fungus Aspergillus fumigatus exhibiting resistance to medical azoles in the environment of Taiwan
Wang, H., Huang, J., Lin, Y., Chen, Y., Hsieh, M., Choi, P., Lo, H., Liu, W., Hsu, C., Shih, H., et al. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13988 · Cited by 47 · see citing works
Emerging fungal resistance
Baddley, J. W., & Moser, S. A. (2004) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2004.05.003 · Cited by 46 · see citing works
Azole Antifungal Resistance Today: Focus on Aspergillus
Bowyer, P., Moore, C. B., Rautemaa, R., Denning, D. W., & Richardson, M. D. (2011) · Current Infectious Disease Reports · doi:10.1007/s11908-011-0218-4 · Cited by 44 · see citing works
Self-citation
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Mellado, E., Alcázar‐Fuoli, L., García‐Effrón, G., Alastruey‐Izquierdo, A., Cuenca‐Estrella, M., & Rodríguez-Tudela, J. L. (2006) · Medical Mycology · doi:10.1080/13693780600902243 · Cited by 43 · see citing works
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Cavalheiro, M., Pais, P., Galocha, M., & Teixeira, M. C. (2018) · Genes · doi:10.3390/genes9070332 · Cited by 42 · see citing works
Exploring the molecular mechanism of azole resistance in Aspergillus fumigatus
Chen, P., Liu, J., Zeng, M., & Sang, H. (2019) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2019.100915 · Cited by 41 · see citing works
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Self-citation
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Kim, Y., Park, S., Kim, D., Choi, J., Lee, Y., Lee, J., & Choi, W. (2013) · Genomics · doi:10.1016/j.ygeno.2013.04.003 · Cited by 40 · see citing works
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Investigating the role of ABC transporters in multifungicide insensitivity in Phytophthora infestans
Judelson, H. S., & Senthil, G. (2005) · Molecular Plant Pathology · doi:10.1111/j.1364-3703.2004.00256.x-i1 · Cited by 39 · see citing works
Yeast ABC proteins involved in multidrug resistance
Piecuch, A., & Obłąk, E. (2013) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-013-0111-2 · Cited by 38 · see citing works
Characterization of the Efflux Capability and Substrate Specificity of Aspergillus fumigatus PDR5-like ABC Transporters Expressed in Saccharomyces cerevisiae
Esquivel, B. D., Rybak, J. M., Barker, K. S., Fortwendel, J. R., Rogers, P. D., & White, T. C. (2020) · mBio · doi:10.1128/mbio.00338-20 · Cited by 35 · see citing works
Differential expression of ATP-binding cassette and/or major facilitator superfamily class efflux pumps contributes to voriconazole resistance in Aspergillus flavus
Natesan, S. K., Lamichchane, A. K., Swaminathan, S., & Wu, W. (2013) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2013.04.022 · Cited by 34 · see citing works
Resistance to antifungal therapies
Prasad, R., Banerjee, A., & Shah, A. H. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160067 · Cited by 33 · see citing works

Multiple Resistance Mechanisms among Aspergillus fumigatus Mutants with High-Level Resistance to Itraconazole
do Nascimento, A. M., Goldman, G. H., Park, S., Marras, S. A. E., Delmas, G., Oza, U., Lolans, K., Dudley, M. N., Mann, P. A., & Perlin, D. S. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.5.1719-1726.2003 · Cited by 256 · see citing works
Identification of Aspergillus fumigatus multidrug transporter genes and their potential involvement in antifungal resistance
Meneau, I., Coste, A. T., & Sanglard, D. (2016) · Medical Mycology · doi:10.1093/mmy/myw005 · Cited by 75 · see citing works
Self-citation
The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus
Fraczek, M. G., Bromley, M., Buied, A., Moore, C. B., Rajendran, R., Rautemaa‐Richardson, R., Ramage, G., Denning, D. W., & Bowyer, P. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt075 · Cited by 313 · see citing works
Self-citation
In Vitro Evolution of Itraconazole Resistance in Aspergillus fumigatus Involves Multiple Mechanisms of Resistance
Ferreira, M. E. D. S., Capellaro, J. L., Marques, E. D. R., Malavazi, I., Perlin, D. S., Park, S., Anderson, J. B., Colombo, A. L., Arthington, B. A., Goldman, M. H. S., et al. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.11.4405-4413.2004 · Cited by 147 · see citing works
Induced expression of a novel Aspergillus fumigatus putative drug efflux gene in response to itraconazole
Slaven, J. W., Anderson, M. J., Dixon, G. K., Roberts, I. S., & Denning, D. W. (1999) · Journal of Infection · doi:10.1016/s0163-4453(99)90201-3 · Cited by 5 · see citing works
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Authors: Slaven, J. W., Anderson, M. J., Sanglard, D., Dixon, G. K., Bille, J., Roberts, I. S., & Denning, D. W.
Affiliations: University of Manchester (GB)
Centre Hospitalier Universitaire Vaudois (CH)
AstraZeneca (United Kingdom) (GB)
Corresponding author: Denning, David W
ORCID: Anderson, Michael J
Sanglard, Dominique
Roberts, Ian S
Denning, David W
Venue: Fungal Genetics and Biology
Publisher: Elsevier BV
Published: 2002-08
Volume: 36
Issue: 3
Pages: 199-206
ISSN: 1087-1845 (ISSN-L)
DOI: 10.1016/s1087-1845(02)00016-6
OpenAlex: W2097302864
Cited by: 202
References: 45
Citations by year: 2026: 11 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 14 · 2016: 12 · 2015: 8 · 2014: 14 · 2013: 12 · 2012: 7
FWCI: 4.23
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Fungal Genetics and Biology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: Medical Research Council
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: Aspergillus fumigatus, ABC transporters, itraconazole resistance, drug efflux, multidrug resistance, gene overexpression, invasive aspergillosis, antifungal resistance
MeSH terms: Amino Acid Sequence, Antifungal Agents, Aspergillus fumigatus, Base Sequence, Cloning, Molecular, Drug Resistance, Microbial, Microbial Sensitivity Tests, Molecular Sequence Data, Immunoblotting, Gene Expression Regulation, Fungal, Itraconazole, ATP-Binding Cassette Transporters

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Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate

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