Cited by 58Growth Hormone and Insulin-like Growth FactorsHormonal and reproductive studiesAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 272 of the 279 references it cites were found in a registry or an index.

Impact of the GH-cortisol ratio on the age-dependent changes in body composition

Nass, R, Thorner, M.O·2002·Growth Hormone & IGF Research

DOI 10.1016/s1096-6374(02)00022-9

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Abstract

Aging is associated with a decrease in GH levels and this is paralleled by changes in body composition, i.e., increased visceral fat, and decreased lean body mass and bone mineral density. Similar changes in body composition are seen in the state of hypercortisolism. Increasing age has been shown to be associated with elevated evening cortisol levels in men. An increased exposure of several tissues to glucocorticoids with aging, i.e., visceral fat cells, in combination with the reduction of the lipolytic effects of declining GH levels, may contribute to the age-dependent increase of visceral fat accumulation. We hypothesize that the age-dependent changes in body fat are the result of an age-dependent decrease of the GH/cortisol ratio at the level of the adipocyte. This is caused by the decline in GH concentrations and the increase in cortisol levels and/or metabolism at the adipocyte.

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Authors: Nass, R., & Thorner, M. O.
Affiliations: University of Virginia Health System (US)
Corresponding author: Thorner, M.O
ORCID: Thorner, M.O
Venue: Growth Hormone & IGF Research
Publisher: Elsevier BV
Published: 2002-06
Volume: 12
Issue: 3
Pages: 147-161
ISSN: 1096-6374 (ISSN-L)
DOI: 10.1016/s1096-6374(02)00022-9
OpenAlex: W1974921448
Cited by: 58
References: 279
Citations by year: 2024: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 3
FWCI: 0.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Growth Hormone & IGF Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: growth hormone, cortisol, aging, body composition, visceral fat, adipocytes, hypercortisolism, lean body mass, bone mineral density, lipolysis, glucocorticoids
MeSH terms: Aging, Animals, Body Composition, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Insulin-Like Growth Factor I, Male, Models, Biological, Obesity, Pituitary-Adrenal System, Growth Hormone, Adipocytes, Human Growth Hormone

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Impact of the GH-cortisol ratio on the age-dependent changes in body composition

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks