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On the site and mechanism of action of the anti-obesity effects of interleukin-6
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“These cytokines have been shown to inhibit appetite and affect lipid metabolism (Langhans and Hrupka, 1999; Jansson et al., 2003).”
From Cigarette Smoking and Brain Regulation of Energy Homeostasis (2012) · cites this paper as Jansson et al., 2003
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Impaired immune and acute-phase responses in interleukin-6-deficient mice
Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature · doi:10.1038/368339a0 · Cited by 1,768
Interleukin-6-deficient mice develop mature-onset obesity
Wallenius, V., Wallenius, K., Ahrén, B., Rudling, M., Carlsten, H., Dickson, S. L., Ohlsson, C., & Jansson, J.-O. (2002) · Nature Medicine · doi:10.1038/nm0102-75 · Cited by 1,213
Self-citationCerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3950 · Cited by 974
Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875
Medicinal strategies in the treatment of obesity
Bray, G. A., & Tartaglia, L. A. (2000) · Nature · doi:10.1038/35007544 · Cited by 432
Research works printed but not linked: 24
- Van Snick, 1990, Interleukin-6: an overview, Annu. Rev. Immunol., 8, 253, 10.1146/annurev.iy.08.040190.001345 · DOI · Paper page
- Hirano, 1998, Interleukin 6 and its receptor: ten years later, Int. Rev. Immunol., 16, 249, 10.3109/08830189809042997 · DOI · Paper page
- Xing, 1998, IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses, J. Clin. Invest., 101, 311, 10.1172/JCI1368 · DOI
- Mohamed-Ali, 1997, Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo, J. Clin. Endocrinol. Metab., 82, 4196
- Orban, 1999, The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man, J. Clin. Endocrinol. Metab., 84, 2126
- Bastard, 2000, Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss, J. Clin. Endocrinol. Metab., 85, 3338
- Jonsdottir, 2000, Muscle contractions induce interleukin-6 mRNA production in rat skeletal muscles, J. Physiol., 528, 157, 10.1111/j.1469-7793.2000.00157.x · DOI
- Schobitz, 1993, Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain, Eur. J. Neurosci., 5, 1426, 10.1111/j.1460-9568.1993.tb00210.x · DOI
- Shizuya, 1998, The expressions of mRNAs for interleukin-6 (IL-6) and the IL-6 receptor (IL-6R) in the rat hypothalamus and midbrain during restraint stress, Life Sci., 62, 2315, 10.1016/S0024-3205(98)00212-4 · DOI
- Friedman, 1998, Leptin and the regulation of body weight in mammals, Nature, 395, 763, 10.1038/27376 · DOI · Paper page
- Bastard, 2002, Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro, J. Clin. Endocrinol. Metab., 87, 2084, 10.1210/jcem.87.5.8450 · DOI
- Wallenius, 2002, Intracerebroventricular interleukin-6 treatment decreases body fat in rats, Biochem. Biophys. Res. Commun., 293, 560, 10.1016/S0006-291X(02)00230-9 · DOI
- Schwartz, 2000, Central nervous system control of food intake, Nature, 404, 661, 10.1038/35007534 · DOI · Paper page
- Wang, 2001, Cytokine and cyclooxygenase-2 protein in brain areas of tumor-bearing mice with prostanoid-related anorexia, Cancer Res., 61, 4707
- Miyahara, 2000, Effects of repeated stress on expression of interleukin-6 (IL-6) and IL-6 receptor mRNAs in rat hypothalamus and midbrain, Life Sci., 66, PL93, 10.1016/S0024-3205(99)00626-8 · DOI
- Gao, 2000, Expression of immunoregulatory cytokines in neurons of the lateral hypothalamic area and amygdaloid nuclear complex of rats immunized against human IgG, Brain Res., 859, 364, 10.1016/S0006-8993(00)02001-1 · DOI
- Li, 2002, Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats, Neuroscience, 115, 879, 10.1016/S0306-4522(02)00447-5 · DOI
- Niimi, 1997, Effect of continuous intravenous injection of interleukin-6 and pretreatment with cyclooxygenase inhibitor on brain c-fos expression in the rat, Neuroendocrinology, 66, 47, 10.1159/000127218 · DOI
- Plata-Salaman, 1996, Anorexia induced by activators of the signal transducer gp 130, NeuroReport, 7, 841, 10.1097/00001756-199602290-00038 · DOI
- Rothwell, 1991, Interleukin-6 is a centrally acting endogenous pyrogen in the rat, Can. J. Physiol. Pharmacol., 69, 1465, 10.1139/y91-219 · DOI
- Caro, 1996, Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance, Lancet, 348, 159, 10.1016/S0140-6736(96)03173-X · DOI · Paper page
- K. Stenlöf, I. Wernstedt, T. Fjällman, V.K.W. Wallenius, J.-O. Jansson, Interleukin-6 levels in the central nervous system are negatively correlated with fat mass in obese subjects, J. Clin. Endocrinol. Metab. (2003) (in press) · DOI · Paper page
- Gloaguen, 1997, Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance, Proc. Natl. Acad. Sci. USA, 94, 6456, 10.1073/pnas.94.12.6456 · DOI
- Lambert, 2001, Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity, Proc. Natl. Acad. Sci. USA, 98, 4652, 10.1073/pnas.061034298 · DOI
Cited by
IL-6 selectively stimulates fat metabolism in human skeletal muscle
Wolsk, E., Mygind, H., Grøndahl, T. S., Pedersen, B. K., & van Hall, G. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00328.2010 · Cited by 221
Cigarette Smoking and Brain Regulation of Energy Homeostasis
Chen, H., Saad, S., Sandow, S. L., & Bertrand, P. P. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00147 · Cited by 69
Metadata
- Authors
- Jansson, J.-O., Wallenius, K., Wernstedt, I., Ohlsson, C., Dickson, S. L., & Wallenius, V.
- Venue
- Growth Hormone & IGF Research
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 13
- Pages
- S28-S32
- ISSN
- 1096-6374
- Cited by
- 28
- References
- 6
- Language
- en
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