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Asymmetric Segregation of PIE-1 in C. elegans Is Mediated by Two Complementary Mechanisms that Act through Separate PIE-1 Protein Domains
Open accessAbstract
The CCCH finger protein PIE-1 is a regulator of germ cell fate that segregates with the germ lineage in early embryos. At each asymmetric division, PIE-1 is inherited preferentially by the germline daughter and is excluded from the somatic daughter. We show that this asymmetry is regulated at the protein level by two complementary mechanisms. The first acts before cell division to enrich PIE-1 in the cytoplasm destined for the germline daughter. The second acts after cell division to eliminate any PIE-1 left in the somatic daughter. The latter mechanism depends on PIE-1's first CCCH finger (ZF1), which targets PIE-1 for degradation in somatic blastomeres. ZF1s in two other germline proteins, POS-1 and MEX-1, are also degraded in somatic blastomeres, suggesting that localized degradation also acts on these proteins to exclude them from somatic lineages.
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Citations
Cites
Mechanisms of asymmetric cell division during animal development
Knoblich, J. A. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80085-3 · Cited by 87
Cited by
Tenenhaus, C., Subramaniam, K., Dunn, M. A., & Seydoux, G. (2001) · Genes & Development · doi:10.1101/gad.876201 · Cited by 357
Self-citationRecognition of the mRNA AU-rich element by the zinc finger domain of TIS11d
Hudson, B. P., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb738 · Cited by 336
Transformation and microinjection
Evans, T. (2006) · WormBook · doi:10.1895/wormbook.1.108.1 · Cited by 296
A C. elegans Piwi, PRG-1, Regulates 21U-RNAs during Spermatogenesis
Wang, G., & Reinke, V. (2008) · Current Biology · doi:10.1016/j.cub.2008.05.009 · Cited by 289
Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic
Balklava, Z., Pant, S., Fares, H., & Grant, B. D. (2007) · Nature Cell Biology · doi:10.1038/ncb1627 · Cited by 281
Metadata
- Authors
- Reese, K. J., Dunn, M. A., Waddle, J. A., & Seydoux, G.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 6
- Issue
- 2
- Pages
- 445-455
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2083844348
- Cited by
- 193
- References
- 1
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Reese, K. J., Dunn, M. A., Waddle, J. A., & Seydoux, G. (2000). Asymmetric Segregation of PIE-1 in C. elegans Is Mediated by Two Complementary Mechanisms that Act through Separate PIE-1 Protein Domains. Molecular Cell. https://doi.org/10.1016/s1097-2765(00)00043-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
