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Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d

Hudson, Brian P, Martinez-Yamout, Maria A, Dyson, H Jane, Wright, Peter E·2004·Nature Structural & Molecular Biology
DOI 10.1038/nsmb738
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Abstract

The tandem zinc finger (TZF) domain of the protein TIS11d binds to the class II AU-rich element (ARE) in the 3' untranslated region (3' UTR) of target mRNAs and promotes their deadenylation and degradation. The NMR structure of the TIS11d TZF domain bound to the RNA sequence 5'-UUAUUUAUU-3' comprises a pair of novel CCCH fingers of type CX(8)CX(5)CX(3)H separated by an 18-residue linker. The two TIS11d zinc fingers bind in a symmetrical fashion to adjacent 5'-UAUU-3' subsites on the single-stranded RNA via a combination of electrostatic and hydrogen-bonding interactions, with intercalative stacking between conserved aromatic side chains and the RNA bases. Sequence specificity in RNA recognition is achieved by a network of intermolecular hydrogen bonds, mostly between TIS11d main-chain functional groups and the Watson-Crick edges of the bases. The TIS11d structure provides insights into the RNA-binding functions of this large family of CCCH zinc finger proteins.

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  • ZFP36 family members interact with AREs containing a UAUUUAUU sequence and trigger degradation of several ARE-containing mRNAs, including PLK3 and VEGFA.

    “ZFP36L1 and ZFP36L2 belong to the family of CCCH tandem zinc finger proteins (the ZFP36 family), members of which interact with AREs containing a UAUUUAUU sequence and trigger the degradation of several ARE-containing mRNAs, including PLK3 and VEGFA (7,8,18,19).”

    From ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK–RSK pathway (2014) · cites this paper as [18]

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Metadata

Authors
Hudson, B. P., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E.
Venue
Nature Structural & Molecular Biology
Publisher
Springer Science and Business Media LLC
Published
2004-02-08
Volume
11
Issue
3
Pages
257-264
ISSN
  • 1545-9993
  • 1545-9985
DOI
10.1038/nsmb738
Cited by
336
References
3
Language
en
Licence
www.springer.com/tdm (tdm)

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