The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans
Open accessAbstract
The CCCH zinc finger protein PIE-1 is an essential regulator of germ cell fate that segregates with the germ lineage during the first cleavages of the Caenorhabditis elegans embryo. We have shown previously that one function of PIE-1 is to inhibit mRNA transcription. Here we show that PIE-1 has a second function in germ cells; it is required for efficient expression of the maternally encoded Nanos homolog NOS-2. This second function is genetically separable from PIE-1's inhibitory effect on transcription. A mutation in PIE-1's second CCCH finger reduces NOS-2 expression without affecting transcriptional repression and causes primordial germ cells to stray away from the somatic gonad, occasionally exiting the embryo entirely. Our results indicate that PIE-1 promotes germ cell fate by two independent mechanisms as follows: (1) inhibition of transcription, which blocks zygotic programs that drive somatic development, and (2) activation of protein expression from nos-2 and possibly other maternal RNAs, which promotes primordial germ cell development.
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Chromatin modification and epigenetic reprogramming in mammalian development
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Metadata
- Authors
- Tenenhaus, C., Subramaniam, K., Dunn, M. A., & Seydoux, G.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2001-04-15
- Volume
- 15
- Issue
- 8
- Pages
- 1031-1040
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2134450913
- Cited by
- 357
- References
- 63
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Tenenhaus, C., Subramaniam, K., Dunn, M. A., & Seydoux, G. (2001). PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans. Genes & Development. https://doi.org/10.1101/gad.876201
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