The DOI matches its Crossref record; 57 of the 63 references it cites were found in a registry or an index.
p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation
Open accessAbstract
Control of p53 turnover is critical to p53 function. E1A binding to p300/CBP translates into enhanced p53 stability, implying that these coactivator proteins normally operate in p53 turnover control. In this regard, the p300 C/H1 region serves as a specific in vivo binding site for both p53 and MDM2, a naturally occurring p53 destabilizer. Moreover, most of the endogenous MDM2 is bound to p300, and genetic analysis implies that specific interactions of p53 and MDM2 with p300 C/H1 are important steps in the MDM2-directed turnover of p53. A specific role for p300 in endogenous p53 degradation is underscored by the p53-stabilizing effect of overproducing the p300 C/H1 domain. Taken together, the data indicate that specific interactions between p300/CBP C/H1, p53, and MDM2 are intimately involved in the MDM2-mediated control of p53 abundance.
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“However, both Mdm2 and Mdmx interact with many other proteins, including those involved in development, morphogenesis and tumorigenesis (Table 2; [81–92]).”
From The p53 orchestra: Mdm2 and Mdmx set the tone (2010) · cites this paper as [87]
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Cites
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Self-citationRegulation of p53 stability by Mdm2
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The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
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CBP/p300 in cell growth, transformation, and development
Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778
The Pezcoller lecture: cancer cell cycles revisited.
Sherr, C. J. (2000) · PubMed · Cited by 1,193
Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53
Fang, S., Jensen, J. P., Ludwig, R. L., Vousden, K. H., & Weissman, A. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8945 · Cited by 1,044
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
Zhou, B. P., Liao, Y., Xia, W., Zou, Y., Spohn, B., & Hung, M.-C. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-973 · Cited by 951
p300/CBP proteins: HATs for transcriptional bridges and scaffolds
Chan, H. M., & La Thangue, N. B. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.13.2363 · Cited by 1,092
Metadata
- Authors
- Grossman, S. R., Perez, M., Kung, A. L., Joseph, M., Mansur, C., Xiao, Z.-X., Kumar, S., Howley, P. M., & Livingston, D. M.
- Affiliations
- Harvard University (US)
- Tufts University (US)
- Boston University (US)
- Corresponding author
- Livingston, David M
- ORCID
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 2
- Issue
- 4
- Pages
- 405-415
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2063877452
- Cited by
- 414
- References
- 63
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 9 · 2019: 4 · 2018: 6 · 2017: 2 · 2016: 9 · 2015: 4 · 2014: 15 · 2013: 15 · 2012: 18
- FWCI
- 19.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- P300, MDM2, p53 degradation, CBP, adenovirus E1A, protein-protein interaction, p53 stabilization, tumor suppressor regulation
- MeSH terms
- Cell Line, DNA-Binding Proteins, Humans, Molecular Sequence Data, Neoplasm Proteins, Nuclear Proteins, Oncogene Proteins, Viral, Protein Binding, Proto-Oncogene Proteins, Ubiquitins, Trans-Activators, Tumor Suppressor Protein p53, Mutagenesis, Sequence Homology, Amino Acid, Proto-Oncogene Proteins c-mdm2
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